Genetic Dissection of Complex Traits
- 2nd Edition, Volume 60 - March 8, 2008
- Latest edition
- Editors: D.C. Rao, C. Charles Gu
- Language: English
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important… Read more
Description
Description
The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
Key features
Key features
- Five sections on the latest advances in complex traits
- Methods for testing with ethical, legal, and social implications
- Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Readership
Readership
Geneticists, molecular biologists, neurobiologists
Table of contents
Table of contents
I OVERVIEW AND FUNDAMENTALS
1 An Overview of Genetic Dissection of Complex Traits
D. C. Rao
2 Familial Resemblance and Heritability
Treva K. Rice
3 Linkage and Association: Basic Concepts
Ingrid B. Borecki and Micheal A. Province
4 Definition of Phenotype
Mary K. Wojczynski and Hemant K.
Tiwari
5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide Scans
Karen Maresso and Ulrich Broeckel
6 Genotyping Errors and their Impact on Genetic Analysis
Michael B. Miller, Karen Schwander, and D.C. Rao
II LINKAGE AND ASSOCIATION ANALYSIS
7 Model-Based Methods for Linkage Analysis
John P. Rice, Nancy L. Saccone and Jonathan Corbett
8 Contemporary Model-Free Methods for Linkage Analysis
Laura Almasy and John Blangero
9 DNA Sequence-Based Phenotypic Association Analysis
Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo
10 Family-Based Methods for Linkage and Association Analysis
Nan M. Laird and Christoph Lange
11 Searching for Additional Disease Loci in a Genomic Region
Glenys Thomson and Lisa F. Barcellos
12 Methods for Handling Multiple Testing
Treva Rice, Nicholas J. Schork and D.C. Rao
III SPECIAL TOPICS
13 Meta-analysis Methods
Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis
14 Haplotype Association Analysis
Nianjun Liu, Kui Zhang, and Hongyu Zhao
15 Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies
C. Charles Gu, Kai Yu, and D.C. Rao
16 Associations among Multiple Markers and Complex Disease: Models, Algorithms, and Applications
Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan and Richard A. Olshen
17 Optimum Study Designs for Genome-Wide Association Studies
Peter Kraft and David G. Cox
18 Ethical, Legal, and Social Implications of Biobanks for Genetics Research
Susanne B. Haga and Laura M. Beskow
IV PROMISING TOPICS
19 Admixture Mapping and the Role of Population Structure for Localizing Disease Genes
Xiaofeng Zhu, Hua Tang, and Neil Risch
20 Integrating Global Gene Expression Analysis and Genetics
Charles R. Farber and Aldons J. Lusis
21 A Systems Biology Approach to Drug Discovery
Jun Zhu, Bin Zhang, and Eric E. Schadt
22 The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges
Na Li
23 Comparative Genomics for Detecting Human Disease Genes
Carol Moreno, Jozef Lazar, Howard J. Jacob and Anne E. Kwitek
V OUTSTANDING CHALLENGES
24 From Genetics to Mechanism of Disease Liability
Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel
25 Into the Post-HapMap Era
Newton E. Morton
1 An Overview of Genetic Dissection of Complex Traits
D. C. Rao
2 Familial Resemblance and Heritability
Treva K. Rice
3 Linkage and Association: Basic Concepts
Ingrid B. Borecki and Micheal A. Province
4 Definition of Phenotype
Mary K. Wojczynski and Hemant K.
Tiwari
5 Genotyping Platforms for Mass Throughput Genotyping with SNPs, including Human Genome-Wide Scans
Karen Maresso and Ulrich Broeckel
6 Genotyping Errors and their Impact on Genetic Analysis
Michael B. Miller, Karen Schwander, and D.C. Rao
II LINKAGE AND ASSOCIATION ANALYSIS
7 Model-Based Methods for Linkage Analysis
John P. Rice, Nancy L. Saccone and Jonathan Corbett
8 Contemporary Model-Free Methods for Linkage Analysis
Laura Almasy and John Blangero
9 DNA Sequence-Based Phenotypic Association Analysis
Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo
10 Family-Based Methods for Linkage and Association Analysis
Nan M. Laird and Christoph Lange
11 Searching for Additional Disease Loci in a Genomic Region
Glenys Thomson and Lisa F. Barcellos
12 Methods for Handling Multiple Testing
Treva Rice, Nicholas J. Schork and D.C. Rao
III SPECIAL TOPICS
13 Meta-analysis Methods
Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, and John P.A. Ioannidis
14 Haplotype Association Analysis
Nianjun Liu, Kui Zhang, and Hongyu Zhao
15 Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies
C. Charles Gu, Kai Yu, and D.C. Rao
16 Associations among Multiple Markers and Complex Disease: Models, Algorithms, and Applications
Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan and Richard A. Olshen
17 Optimum Study Designs for Genome-Wide Association Studies
Peter Kraft and David G. Cox
18 Ethical, Legal, and Social Implications of Biobanks for Genetics Research
Susanne B. Haga and Laura M. Beskow
IV PROMISING TOPICS
19 Admixture Mapping and the Role of Population Structure for Localizing Disease Genes
Xiaofeng Zhu, Hua Tang, and Neil Risch
20 Integrating Global Gene Expression Analysis and Genetics
Charles R. Farber and Aldons J. Lusis
21 A Systems Biology Approach to Drug Discovery
Jun Zhu, Bin Zhang, and Eric E. Schadt
22 The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges
Na Li
23 Comparative Genomics for Detecting Human Disease Genes
Carol Moreno, Jozef Lazar, Howard J. Jacob and Anne E. Kwitek
V OUTSTANDING CHALLENGES
24 From Genetics to Mechanism of Disease Liability
Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel
25 Into the Post-HapMap Era
Newton E. Morton
Product details
Product details
- Edition: 2
- Latest edition
- Volume: 60
- Published: April 23, 2008
- Language: English
About the editor
About the editor
DR
D.C. Rao
Affiliations and expertise
Washington University School of Medicine, St. Louis, MO, USAView book on ScienceDirect
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