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Elsevier

Xenobiotics in Chemical Carcinogenesis

Translational Aspects in Toxicology

  • 1st Edition - February 17, 2022
  • Latest edition
  • Authors: Akhileshwar Kumar Srivastava, Dhruv Kumar, Divya Singh, Rajesh Kumar Singh
  • Language: English

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxic… Read more

Description

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development.

Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.

Key features

  • Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers
  • Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation
  • Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis
  • Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans

Readership

Researchers, university professors, MSc, MPH, and early PhD students in working in the areas of toxicology, xenobiotics substances, and cancer research. Researchers, academics, graduate students in environmental science, pharmaceutical sciences, oncology, and biotechnology

Table of contents

1. A historical review and future prospective of chemical carcinogenesis

2. Role of xenobiotics metabolism in carcinogenesis

3. Recalcitrant of toxic xenobiotics and its routes of exposure to human

4. Major environmental xenobiotics risk for different cancers

5. Toxicokinetic and toxicodynamic of xenobiotics in cancer development

6. Mechanism of oxidative stress in carcinogenesis induced by xenobiotics

7. Genotoxic and non-genotoxic activities of cancer-inducing xenobiotics

8. Modulation of epigenome by xenobiotics in cancer

9. Carcinogenic effects of nanomaterials with emphasis on nanoplastics

10. Endocrine disruptor activity of xenobiotics in carcinogenesis

11. Environmental exposures (Bisphenol A and phatalates) as xenoestrogens enhance risk for breast cancer

12. Biotransformation of toxic xenobiotics by human gut microbiota

13. Mechanism of resistance to toxic xenobiotics in human

14. Profiling the reactive metabolites of xenobiotics in cancer

15. Toxicogenomic for prediction of carcinogenicity of xenobiotic substances

Product details

  • Edition: 1
  • Latest edition
  • Published: February 21, 2022
  • Language: English

About the authors

AS

Akhileshwar Kumar Srivastava

Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) at CSIR-Central Food Technological Research Institute, Mysore, India. In his 11 years of research, he has published more than 18 research articles in reputed international journals, along with 4 books and 11 book chapters. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology associated with targeting virulent factors of diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, USA, on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in the Indian Science Congress and the Agriculture, Nutrition and Health Academy, UK.

Affiliations and expertise
CSIR-Central Food Technological Research Institute, Mysore, India

DK

Dhruv Kumar

Dr. Dhruv Kumar is a Senior Associate Professor at School of Health Sciences and Technology, UPES University, Dehradun, India and his current research is focused on autophagy, cancer cell metabolism, tumour microenvironment, exosomes, mutational heterogeneity, cancer prevention, drug designing, NGS and COVID-19. After completion of B.Sc. in Chemistry from Banaras Hindu University (BHU) and M.Sc. in Bioinformatics from University of Allahabad, India, he has completed his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), under highly prestigious fellowship, Indo-Italian Government fellowship. After his Ph.D., he obtained Postdoctoral training at the University of Kansas Medical Center, USA. During his Postdoctoral training, he worked towards understanding the molecular mechanism(s) of autophagy regulation and apoptosis in cancer stem cells (prostate, pancreatic and breast), focusing on the metabolic cross-talk between the tumour microenvironment (cancer associated fibroblast (CAF)) and head and neck squamous cell carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signalling pathways. He has also worked on structure based drug designing for several cancers, COVID-19, mutational heterogeneity in cancer. Currently, his lab is focusing on metabolic heterogeneity in solid tumours and structure based drug designing for cancer and COVID-19. He has published more than 100 research articles, reviews and book chapters in reputed journals.
Affiliations and expertise
Senior Associate Professor at School of Health Sciences and Technology, UPES University, Dehradun, India

DS

Divya Singh

Dr. Divya Singh is presently working as a scientist in Central Sericultural Research and Training Institute, Mysore, India. Her research specialization is primarily in genetics, proteomics, metabolomics, toxicology, bioinformatics, and molecular biological evaluation in various in vivo and in vitro plant models to elucidate the physiological changes and evaluate the DNA damage potency. She has published more than 10 research articles including book chapters. In addition, she is also a life member fellow of Indian Science Congress.
Affiliations and expertise
Scientist, Central Sericultural Research and Training Institute, Mysore, India

RS

Rajesh Kumar Singh

Dr. Rajesh Kumar Singh is currently working as a Research Associate in Banaras Hindu University. His research focus is pharmacognosy, reverse pharmacology, drug design and discovery, extraction & isolation of natural products, cell culture, and handling of different rodents. He has published several research articles in reputable journals over the course of his career. At present, he is involved in developing an Indian origin cell line and screening drugs of natural origin for the treatment of gallbladder cancer.
Affiliations and expertise
Research Associate, Centre of Experimental Medicine and Surgery at Banaras Hindu University, India

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