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Elsevier

A History of Angiogenesis

Discoveries, Research and the Therapeutic Potential

  • 1st Edition - December 2, 2025
  • Latest edition
  • Editors: Gianfranco Natale, Guido Bocci, Domenico Ribatti
  • Language: English

A History of Angiogenesis: Discoveries, Research and the Therapeutic Potential presents a recent history of discoveries in the angiogenic field that contribute to the developme… Read more

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Description

A History of Angiogenesis: Discoveries, Research and the Therapeutic Potential presents a recent history of discoveries in the angiogenic field that contribute to the development of the anatomical knowledge of the process, experimental models, and new pharmacological approaches in different angiogenesis-related diseases. This multifaceted book is enriched with deep scientific contents, and each chapter clearly defines historical steps, the emerging role during the years of new morphological findings, molecular pathways, and targets. Focus is also directed on key challenges associated and future directions.

The history of angiogenesis research is an intriguing tool for discovering answers to a wide array of queries arising in the biological and medical world. This comprehensive resource skillfully integrates all the key aspects related to angiogenesis, and will be of immense help to students, researchers, and industry experts who want to explore the last two decades of angiogenesis discoveries and research.

Key features

  • Provides information related to the history of angiogenesis
  • Presents information on the morphological aspects in the angiogenic process and how it has changed over time
  • Covers experimental approaches to investigate the angiogenic process
  • Provides a comprehensive overview of pharmacological tools in the field of angiogenesis

Readership

Researchers, students, teachers, industry professionals and many others who are exploring novel targets, molecular pathways, and drug delivery approaches in angiogenesis-related diseases.The book will also be valuable to academic institutions, senior and junior academic researcher, pharmaceutical companies, and research institutions. Also, PhD students, undergraduate students and postdoctoral fellows working in the field of angiogenesis-related diseases, drug discovery and drug development

Table of contents

1 Introduction
Gianfranco Natale, Domenico Ribatti and Guido Bocci

2 Angiogenesis before 2000—Cardiovascular system and angiogenesis during the centuries
Gianfranco Natale

3 Vasculogenesis, angiogenesis, and new types of vascular growth
Domenico Ribatti

4 In vitro and in vivo assays
Domenico Ribatti

5 New frontiers in angiogenesis research
Gianfranco Natale

6 New frontiers of lymphangiogenesis
Gianfranco Natale

7 Early work on the development of inhibitors of angiogenesis as antitumor agents
Diana L. Prospero, Saeedeh Darvishi, Claire E.I. Perucho, Valeria V. Lopez and Giulio Francia

8 Approved antiangiogenic and proangiogenic drugs in the past two decades: a historical landscape of the therapeutic opportunities
Guido Bocci

9 Metronomic chemotherapy: more than 20 years of preclinical and clinical evidence
Arianna Bandini and Guido Bocci

Product details

  • Edition: 1
  • Latest edition
  • Published: December 2, 2025
  • Language: English

About the editors

GN

Gianfranco Natale

Prof. Gianfranco Natale has a degree in Medicine and Surgery, and attended a Specialization Course in Clinical Pharmacology at University of Pisa, Italy. His didactic activity (human anatomy) is delivered in several university courses of the medical area, including doctorate courses, masters and winter and summer schools. As academician he has many publications in various national and international journal of repute, with h-index 25. He has presented 150 research abstracts in various national and international conferences. His areas of interest in research include the following topics: morphofunctional alterations induced by stressing agents (electromagnetic fields, noise) in different organs, including heart and adrenal gland; morphometry, pharmacology and physiopathology of the experimental peptic ulcer; morphofunctional alterations of the gastrointestinal tract in experimentally induced neurodegenerative diseases; studies of gross anatomy, with particular reference to myofascia. He is director of the Museum of Human Anatomy “Filippo Civinini” of the University of Pisa. For this reason, he is of also having expertise in history of medicine, with a particular attention to anatomy.
Affiliations and expertise
Associate Professor, School of Medicine, University of Pisa, Pisa, Italy

GB

Guido Bocci

Guido Bocci, MD PhD, is currently a Full Professor of Pharmacology at the University of Pisa. He is an European Certified Pharmacologist (EuCP). He maintains relevant international collaborations with various groups in Europe and North America. His international experience is closely related to the 3-year post-doctoral fellowship at the University of Toronto in the Kerbel’s Laboratory, with whom he continued to work in the following decades on numerous projects. He has been a PI of various projects granted by AIRC, ITT and foundations. He is in the editorial board of various journals, associate editor of Frontiers in Oncology, Frontiers in Pharmacology and regional editor of Clinical Cancer Drugs. He has been a grant reviewer for UK association for Cancer Research, South Plains Foundation (USA), French National Cancer Institute (France), Genesis Oncology Trust (New Zealand), Innsbruck Medical University (Austria), United States-Israel Binational Science Foundation and The German Israeli Foundation. Prof. Bocci is author of 4 national and 3 international patents, he has published 174 articles on international journals, 18 chapters on international and national books, and 1 international book as an editor on metronomic chemotherapy. The main research activity of Prof. Bocci has been focused on antineoplastic chemotherapy and antiangiogenic research, including both in vitro and in vivo experimental settings, and clinical pharmacology of chemotherapeutic drugs and antiangiogenic therapies. He has been deeply involved in the birth and development of metronomic chemotherapy concept in both pre-clinical and clinical trials.
Affiliations and expertise
Full Professor, School of Medicine, University of Pisa, Pisa, Italy

DR

Domenico Ribatti

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times. He has published many books with both Elsevier and Springe
Affiliations and expertise
Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy

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