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Adenosine A2A Receptor Antagonists

  • 1st Edition, Volume 170 - September 19, 2023
  • Latest edition
  • Editors: Jiang-Fan Chen, Akihisa Mori
  • Language: English

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting in… Read more

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Description

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson’s disease therapy, and much more.

Key features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the International Review of Neurobiology
  • Updated release includes the latest information on Adenosine A2A Receptor Antagonists

Readership

Undergraduates, graduates, academics, and researchers in the field of Adenosine A2A Receptor Antagonists

Table of contents

1. A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonists
Kenneth A. Jacobson

2. Chemistry – agonists, antagonists, partial agonists, inverse agonists
Christa Müller

3. Functional roles of adenosine receptors – biochemistry and neuronal plasticity
Ana Sebastiao

4. A2A and Depression
Rodrigo Cunha

5. A2AR and glial function
Zhihua Gao

6. The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signalling
Rafael Franco, Gemma Navarro and Eva Martinez-Pinilla

7. How and why A2a receptor become to be a therapeutic target in Parkinson’s disease therapy
Peter Jenner

8. Development of A2a antagonists for Parkinson’s disease – clinical evaluation for motor and non-motor symptoms
Yasar Torres-Yaghi

9. The role of A2AR in chemobrain and the potential therapeutic benefits of istradefylline
Detlev Boison and Mi-hyeon Jang

10. Effects of adenosine A2A receptors on cognitive function in health and disease
Anna G. Orr, Cinthia Garcia and Avital Licht-Murava

11. A2a receptor and Sleep disturbance
Michael Lazarus and Mustafa Korkutata

12. Adenosine A2A signals and Dystonia
Makio Takahashi

13. Protective potential of caffeine and adenosine A2A adenosine receptor antagonism in LRRK2 Parkinson’s disease
Michael Schwarzschild

14. A2a antagonists and Alzheimer’s disease
David Blum

15. A2a receptors and ALS/MS
Zheng Wu

16. A2AR and trauma/PTSD
Yuanguo Zhou

Product details

  • Edition: 1
  • Latest edition
  • Volume: 170
  • Published: September 19, 2023
  • Language: English

About the editors

JC

Jiang-Fan Chen

Jiang-Fan Chen, MD, PhD, is an Associate Professor in the Boston University Medical Campus--Departments of Neurology and Pharmacology and Experimental Therapeutics. Dr. Chen’s research focuses on the neurobiology of adenosine and the A2A adenosine receptor and the role they may play in the development and treatment of neuropsychiatric disorders. Dr. Chen has developed an A2A receptor knockout mouse model and couples this genetic approach with pharmacological manipulation to explore the pathophysiological role of A2A receptors in animal and cellular models of neuropsychiatric disorders. The knowledge derived from these studies may provide the neurobiological basis for rational development of A2A receptor agents as treatment strategies for neuropsychological disorders, ranging from Parkinson’s disease to drug addiction.
Affiliations and expertise
Associate Professor, Departments of Neurology and Pharmacology and Experimental Therapeutics, Boston University Medical Center, MA, USA

AM

Akihisa Mori

Akihisa Mori, Ph.D., is a global expert for Adenosine receptor neuroscience as well as Parkinson’s disease, having more than 3 decades experience to work for pharmaceutical industry from basic science, exploratory and translational research to global clinical development, for antiparkinsonian therapeutics. As for adenosine receptor neuroscience, he has discovered a functional significance of Adenosine A2A receptor in the basal ganglia as well as the adenosine A2A receptor antagonism mode of action as antiparkinsonian therapy. Also, he has made global leadership to develop a first-in class adenosine A2A receptor antagonist, Istradefylline, delivering the product to successful approval in the US and Japan. He has previously participated to be the Editor for volume 119 (Adenosine Receptors in Neurology and Psychiatry) of International Review of Neurobiology.
Affiliations and expertise
SNLD Ltd., Japan

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