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Advanced MR Techniques for Neurodegenerative Diseases

  • 1st Edition, Volume 14 - August 1, 2026
  • Latest edition
  • Editors: Kannie Wy Chan, Paul G Unschuld, Peter CM Van Zijl, Linda Knutsson
  • Language: English

Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides… Read more

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Description

Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.

Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

Key features

  • The basics of perfusion MRI approaches
  • Current approaches for imaging the glymphatic system
  • Non-invasive molecular imaging using CEST MRI
  • The use of rsfMRI to assess neurodegeneration
  • Microscopic tissue property assessment using diffusion MRI and magnetic susceptibility MRI

Readership

MR engineers and physicists developing MR technologies, clinicians and neuroscientists who use MR techniques for diagnosis and neurodegenerative research

Table of contents

1: Introduction

Part 2: Basics of the relevant MRI technology (Acquisition, analysis and interpretation for neurodegenerative diseases)

2.1 Perfusion

2.1.1 Arterial Spin Labelling

2.1.2 Dynamic Contrast Enhanced MRI

2.1.3 Dynamic Susceptibility MRI

2.2 Flow (MRA, CSF, large vessel

2.3 Chemical Exchange Saturation Transfer and Magnetization Transfer Contrast–

2.4 Magnetic Resonance Spectroscopy

2.5 Resting State fMRI

2.6 Microscopic Diffusion Imaging

2.7 Susceptibility Weighted imaging and Quantitative Susceptibility Mapping

Part 3: Imaging the glymphatic system

3.1 Glymphatic system

3.2 DCE MRI of glymphatic system

3.3 CSF imaging

3.4

Part 4: Neurodegenerative diseases and neurovascular pathology - current state-of-art in MRI

4.1 Alzheimer’s disease -

4.1.1 The disease

4.1.2 Imaging animal models

4.1.3 Human imaging state of the art

4.2 Vascular dementia and cerebral small vessel

4.2.1 The disease

4.2.2 Imaging animal models

4.2.3 Human imaging state of the art

4.3 Parkinson’s and Lewy body dementia

4.3.1 The disease

4.3.2 Imaging animal models

4.3.3 Human imaging state of the art

4.4 Huntington’s disease

4.4.1 The disease

4.4.2 Imaging animal models

4.4.3 Human imaging state of the art

4.4.4

4.5 Amyotrophic Lateral Sclerosis

4.5.1 The disease

4.5.2 Imaging animal models

4.5.3 Human imaging state of the art

4.6 Multiple Sclerosis

4.6.1 The disease

4.6.2 Imaging animal models

4.6.3 Human imaging state of the art

Part 5: Future research challenges and directions - Editors

Product details

  • Edition: 1
  • Latest edition
  • Volume: 14
  • Published: August 1, 2026
  • Language: English

About the editors

KC

Kannie Wy Chan

Dr. Chan received her BSc and PhD degrees from The University of Hong Kong. She conducted post-doctoral research in biomaterials and medical imaging with a focus on MRI at Department of Radiology at Johns Hopkins University School of Medicine in 2010, and became the Assistant Professor in 2014. She joined The City University of Hong Kong in 2016. Her research focuses on the development of biomaterials and imaging techniques to facilitate the clinical translation of cell therapy and cancer therapy. This includes the use of an emerging MRI contrast mechanism for molecular imaging, which is known as chemical exchange saturation transfer (CEST). She published over 30 peer-reviewed articles, including the cover article in Nature Materials.
Affiliations and expertise
Department of Biomedical Engineering, City University of Hong Kong; Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, USA

PU

Paul G Unschuld

Paul G Unschuld works in the Department of Psychiatry, Geneva University Hospitals (HUG) and University of Geneva (UniGE), Geneva, Switzerland.
Affiliations and expertise
Department of Psychiatry, Geneva University Hospitals (HUG) and University of Geneva (UniGE), Geneva, Switzerland

PV

Peter CM Van Zijl

Dr. Peter C.M. van Zijl is a research scientist at Kennedy Krieger Institute, as well as the founding director of the F.M. Kirby Research Center for Functional Brain Imaging. He is also a professor of radiology at the Johns Hopkins University School of Medicine. Dr. van Zijl’s present research focuses on developing new methodologies for using MRI and Magnetic Resonance Spectroscopy (MRS) to study brain function and physiology. In addition, he is working on understanding the basic mechanisms of the MRI signal changes measured during functional MRI (fMRI) tests of the brain. Other interests are in mapping the wiring of the brain (axonal connections between the brains functional regions) and the design of new technologies for MRI to follow where cells are migrating, and when genes are expressed. A more recent interest is the development of bioorganic, biodegradable MRI contrast agents. The ultimate goal is to transform these technologies into fast methods that are compatible with the time available for multi-modal clinical diagnosis using MRI. He is especially dedicated to providing a comfortable scanning environment for children, where they can enjoy the experience in the MRI scanner.
Affiliations and expertise
Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, US; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, US.

LK

Linda Knutsson

Dr. Linda Knutsson is a Professor at the F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute. She also is a Professor of Medical Radiation Physics at Lund University, Sweden and group leader of the MR-physics group in Lund (40 members).

Dr. Knutsson’s research is mainly focused on perfusion (microvascular blood flow) and perfusion-related measurements using MRI. The main target parameters are cerebral blood flow, cerebral blood volume, mean transit time, permeability and oxygen extraction fraction. Relevant methods that Dr. Knutsson is working with are arterial spin labelling (ASL), dynamic contrast enhanced (DCE) MRI and dynamic susceptibility contrast (DSC) MRI. Dr. Knutsson’s research also includes an emerging technique called chemical exchange saturation transfer (CEST) MRI to retrieve perfusion and perfusion related parameters using natural sugar. For her research contributions she received the Kurt Lidén’s Award - 2015, from the Swedish Society of Radiation Physics.

Affiliations and expertise
Professor, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, USA