Advances in Clinical Chemistry

Chapter One: Antibodies to Phosphatidylserine/Prothrombin Complex in Antiphospholipid Syndrome: Analytical and Clinical Perspectives

• Abstract
• 1 Introduction
• 2 Historic Background to aPL
• 3 “Criteria” Antiphospholipid Antibody Tests
• 4 aPL and Pathogenesis of APS
• 5 Antibodies to Phosphatidylserine/Prothrombin Complex
• 6 Clinical and Laboratory Significance of aPS/PT Antibodies
• 7 Analytic and Diagnostic Challenges Associated with aPS/PT Antibodies
• 8 Perspectives and Opportunities for the Future
• 9 Conclusion

Chapter Two: Copeptin in Heart Failure

• Abstract
• 1 Introduction
• 2 Neurohormonal Activation in HF
• 3 The Vasopressin System in HF
• 4 Limitations of Vasopressin Measurements in Clinical Settings
• 5 Structure and Function of Copeptin
• 6 Copeptin in Healthy Populations
• 7 Copeptin in Other Heart Diseases than HF
• 8 Copeptin in HF
• 9 Association of Copeptin and Hyponatremia in HF
• 10 Copeptin and Comorbidity in HF
• 11 Copeptin and Medical Therapy in HF
• 12 Conclusion and Future Perspectives on Copeptin in HF
• Acknowledgments

Chapter Three: Immunosensors in Clinical Laboratory Diagnostics

• Abstract
• 1 Introduction
• 2 Classification of Immunosensors
• 3 Applications of Immunosensors for Clinical Diagnostics
• 4 Final Remarks and Perspectives
• Acknowledgments

Chapter Four: Cancer Stem Cell Biomarker Discovery Using Antibody Array Technology

• Abstract
• 1 Introduction
• 2 Evidence of Cancer Stem Cell Populations in Circulating Tumors: Biomarker-Based CSC Discovery
• 3 Antibody Array-Based Discovery of Local Cancer Stem Cell Signaling Mechanisms
• 4 Conclusions
• Acknowledgments

Chapter Five: Biochemistry of Statins

• Abstract
• 1 Introduction
• 2 Structure
• 3 Pharmacokinetics
• 4 Mechanism of Action
• 5 Administration
• 6 Efficacy
• 7 Side Effects
• 8 Statin Intolerance
• 9 Conclusion

Chapter Six: The Importance of Magnesium in the Human Body: A Systematic Literature Review

• Abstract
• 1 Introduction
• 2 Method
• 3 Results
• 4 Discussion
• 5 Conclusion

Chapter Seven: Inborn Errors of Metabolism

• Abstract
• 1 Inborn Errors of Metabolism