Advances in Drug Research

Contributors

Preface

Extrapolation of Toxicological and Pharmacological Data from Animals to Humans

1 Overview

2 Introduction

3 The Surface Law

4 Allometric Relationships and Biological Similarity

5 Pharmacokinetics and Comparative Metabolism

6 Discussion and Conclusions

References

Tissue Binding versus Plasma Binding of Drugs: General Principles and Pharmacokinetic Consequences

1 Introduction

2 Pharmacokinetic Consequences of Plasma and Tissue Binding

3 Methods to Assess Tissue Binding of Drugs

4 Tissue Binding versus Plasma Binding of Drugs

5 Conclusion

References

Search for New Drugs of Plant Origin

1 Introduction

2 Anticancer Agents from Higher Plants

3 Antagonists of Platelet-activating Factor

4 Antimalarial Agents

5 AIDS—Antiviral Agents

6 Miscellaneous

7 Concluding Remarks

References

Histaminergic Agonists and Antagonists: Recent Developments

1 Introduction

2 Histamine HrReceptor Ligands

3 Histamine H2-Receptor Ligands

4 Histamine H3-Receptor Ligands

5 Concluding Remarks

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles