Advances in Drug Research

Contributors

Preface: "All Mimsy Were the Borogoves"

Atom Description in QSAR Models: Development and Use of an Atom Level Index

1 Introduction

2 An Atom Level Description of Structure

3 Formulation of an Atom-Centered Index

4 Information from Electrotopological State Values

5 QSAR Strategy

6 Applications to Drug QSAR Problems

7 Discussion

References

Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges

1 Introduction

2 Physicochemical Factors and Passive Distribution

3 Clearance

4 Transport of Peptides Across Mucosal Surfaces

5 Conclusions

References

Towards Genomic Pharmacology: From Membranal to Nuclear Receptors

1 Introduction

2 Regulation of Gene Expression

3 Nuclear Receptors

4 Induced Changes in Gene Expression

5 The Nucleus as a Target for Drug Action

6 Signal Pathways: From Membrane to Nuclear Receptors

7 Future Prospects

References

Medicinal Chemistry of Steroids: Recent Developments

1 Introduction

2 Steroid Receptors

3 Steroid-Converting Enzymes: The Case of 3-Oxo-Δ5-Steroid Isomerase

4 Inhibitors of Steroid-Converting Enzymes

5 Oestrogen Receptor-Based Imaging Agents

6 Conclusions and Future Developments

References

Subject Index

Cumulative Index of Authors

Cumulative Index of Titles