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Elsevier

Advances in Genetics

  • 1st Edition, Volume 87 - October 9, 2014
  • Latest edition
  • Editors: Theodore Friedmann, Jay C. Dunlap, Stephen F. Goodwin
  • Language: English

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continual… Read more

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Description

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Volume 87 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: gene transfer, fruiting body development and the genetics of Alzheimer’s disease; and more.

Key features

  • Includes methods for testing with ethical, legal, and social implications
  • Critically analyzes future directions
  • Written and edited by recognized leaders in the field

Readership

Molecular geneticists, clinical geneticists, neurologists, neuroscientists, molecular biologists, and biochemists.

Table of contents

  • Advances in Genetics, Volume 87
  • Chapter One. Opportunity for Selection in Human Health
    • 1. Introduction
    • 2. Genetic Variation and Demographic Selection
    • 3. Episodes of Selection
    • 4. Selection Spectra
    • 5. Place of Multilevel Selection in Medical Practice and Public Health
    • 6. Discussion
  • Chapter Two. Clinical Applications Involving CNS Gene Transfer
    • 1. Introduction
    • 2. CNS Clinical Trials Utilizing Retroviral Vectors
    • 3. CNS Clinical Trials Utilizing AAV Vectors
    • 4. Lessons Learned from Related Studies
    • 5. Conclusion
  • Chapter Three. Methods for Gene Transfer to the Central Nervous System
    • 1. Introduction
    • 2. Vectors for CNS Gene Transfer
    • 3. Genome Designs for Optimal Expressions
    • 4. Conclusions
  • Chapter Four. The Filamentous Fungus Sordaria macrospora as a Genetic Model to Study Fruiting Body Development
    • 1. Introduction
    • 2. Genetic and Genomic Tools
    • 3. The Striatin-Interacting Phosphatase and Kinase Complex, a Multisubunit Protein Complex Governing Fruiting Body Development
    • 4. Chromatin-Related Processes
    • 5. Metabolism-Related Developmental Processes
    • 6. Autophagy
    • 7. Concluding Remarks and Outlook
  • Chapter Five. Genetics of Alzheimer’s Disease
    • 1. Introduction
    • 2. Heritability of Alzheimer’s Disease
    • 3. Genetic Causes of Early-Onset Alzheimer’s Disease
    • 4. Genetic Risk Factors for Late-Onset Alzheimer’s Disease
    • 5. Discussion
  • Index

Review quotes

Praise for previous volumes in the series: "Outstanding both in variety and in the quality of its contributions."–Nature

"Can be highly recommended to geneticists, and biologists in general...will prove to be of high importance for the development of the science of genetics."—Science

Product details

  • Edition: 1
  • Latest edition
  • Volume: 87
  • Published: October 9, 2014
  • Language: English

About the editors

TF

Theodore Friedmann

School of Medicine, University of California at San Diego, USA
Affiliations and expertise
School of Medicine, University of California at San Diego, USA

JD

Jay C. Dunlap

Dr. Jay Dunlap works at the Geisel School of Medicine at Dartmouth.
Affiliations and expertise
The Geisel School of Medicine, Dartmouth, NH, USA

SG

Stephen F. Goodwin

Dr. Stephen Goodwin works at the University of Oxford.
Affiliations and expertise
University of Oxford, UK

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