Advances in Immunology

Series Page

Contributors

Chapter One. The Interdisciplinary Science of T-cell Recognition

1 Introduction

2 The First Level of Complexity: The Kinetics and Structural Basis of TCR–pMHC Engagement

3 The Second Level of Complexity: The TCR–CD3 Complex and Approaches to Answers of How It Works

4 The Third Level of Complexity: Antigen Recognition and the Immunological Synapse

5 Perspective

Acknowledgments

References

Chapter Two. Residual Immune Dysregulation Syndrome in Treated HIV infection

1 The Role of Activation and Inflammation in the Natural History of Infection

2 Inflammatory and Coagulation Indices Predict Morbidity in Treated HIV Infection

3 Persistent CD4 + T Cell Lymphopenia Predicts Clinical Outcomes During ART

4 Immune Activation/Inflammation Predicts Morbidity and Mortality During ART

5 Failure to Restore Circulating CD4 + T Cells in HIV Infection

6 The LN in Treated HIV Infection

7 The Gut in Treated HIV Infection

8 Other Possible Drivers of Residual Immune Dysregulation in Treated HIV Infection

9 Therapeutic Approaches

10 Summary

Acknowledgment

References

Chapter Three. Developmental Plasticity of Murine and Human Foxp3⁺ Regulatory T Cells

1 Introduction

2 Stability and Plasticity of Regulatory T Cells

3 A Transient Flexibility Model for Regulatory T Cell Plasticity

4 Differences in Foxp3/FOXP3 Between Mice and Humans

5 Significance and Future Directions

Acknowledgments

References

Chapter Four. Logic of the Inflammation-Associated Transcriptional Response

1 Dynamic of Inflammatory Gene Expression—Bursts and Noise

2 Control of Inflammation by RNA Elongation

3 Pharmacological Targeting of RNA Elongation by BET Antagonists

4 Targeting of Inflammation by Pathogen-Derived Chromatin Modifiers

5 Concluding Remarks

References

Chapter Five. Structural Basis of Signal Transduction in the TNF Receptor Superfamily

1 Introduction

2 NF-κB Activation

3 TNFR1 and Fas-Induced Apoptosis

4 TNFR1-Induced Programmed Necrosis

5 Conclusions

Acknowledgment

References

Index

Contents of Recent Volumes