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Advances in Molecular Toxicology

  • 1st Edition, Volume 8 - September 30, 2014
  • Latest edition
  • Editors: James C. Fishbein, Jacqueline M. Heilman
  • Language: English

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this… Read more

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Description

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

Key features

  • Cutting-edge reviews by leading workers in the discipline
  • In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines
  • Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Readership

For academics in the field of chemistry, biochemistry, toxicology, pharmacology medicine; for Government agencies and those in industry, pharmaceutical and chemical manufacturers

Table of contents

  • Preface
  • Chapter One: The Mechanistic Complexities of Phycotoxins: Toxicology of Azaspiracids and Yessotoxins
    • Abstract
    • 1 Introduction
    • 2 Azaspiracids
    • 3 Yessotoxins
    • Acknowledgments
  • Chapter Two: Advances in the Analysis of Challenging Food Contaminants: Nanoparticles, Bisphenols, Mycotoxins, and Brominated Flame Retardants
    • Abstract
    • 1 Introduction
    • 2 Analytical Methodology for the Analysis of Nanoparticles
    • 3 Analytical Methodology for the Analysis of Bisphenols
    • 4 Analytical Methodology for the Analysis of Mycotoxins
    • 5 Analytical Methodology for the Analysis of BFRs
    • 6 Conclusions
    • Acknowledgments
  • Chapter Three: Mycotoxins from Alternaria: Toxicological Implications
    • Abstract
    • 1 Introduction
    • 2 Chemical Structures
    • 3 Acute Toxicity
    • 4 Toxicokinetics and Metabolism
    • 5 Genotoxicity and Related Mechanism
    • 6 Estrogenic Activity and Related Mechanisms
    • 7 Mutagenicity and Carcinogenicity
    • 8 Gastrointestinal Stability of AOH and ALT Under In Vitro Human Conditions
    • 9 Conclusions and Outlook
  • Chapter Four: Food-Borne Topoisomerase Inhibitors: Risk or Benefit
    • Abstract
    • 1 Introduction
    • 2 Catalytic Enzyme Cycle
    • 3 Drug–DNA Interaction: “Inhibitor Versus Poison”
    • 4 Topoisomerase Inhibitors in Cancer Therapy
    • 5 Secondary Plant Constituents as Topoisomerase Inhibitors
    • 6 Conclusion
    • Acknowledgments
  • Chapter Five: Toxicity of Plasmonic Nanomaterials and Their Hybrid Nanocomposites
    • Abstract
    • 1 Introduction
    • 2 Toxicity Testing and Risk Assessment of Nanomaterials
    • 3 Toxicity Evaluation
    • 4 Animal Testing for Toxicity
    • 5 Factors Affecting Nanotoxicology
    • 6 Genotoxicology
    • 7 The Most Common Genotoxicological Tests
    • 8 Genotoxicity of Plasmonic Nanomaterials
    • 9 Evaluation of Genotoxicity of Magneto-Plasmonic Hybrid Nanocomposites
    • 10 Conclusion
  • Chapter Six: Aluminum Phytotoxicity: Physiological Approaches and Tolerance
    • Abstract
    • 1 General Considerations
    • 2 Aluminum and Plants’ Responses
    • 3 Aluminum and the Apoplast–Symplast Continuum
    • 4 Aluminum and Oxidative Stress
    • 5 Aluminum and Callose Deposition
    • 6 Aluminum and Photosynthesis
    • 7 Aluminum Tolerance
    • 8 Final Remarks
    • Acknowledgments
  • Index

Product details

  • Edition: 1
  • Latest edition
  • Volume: 8
  • Published: October 10, 2014
  • Language: English

About the editors

JF

James C. Fishbein

Dr. James Fishbein works at the Department of Chemistry and Biochemistry, University of Maryland.
Affiliations and expertise
Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA

JH

Jacqueline M. Heilman

Dr. Jacqueline Heilman works at Exponent, Inc., Washington, DC, USA
Affiliations and expertise
Exponent, Inc., Washington, DC, USA

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