Advances in Virus Research

Chapter One: Peste des Petits Ruminants Virus

• Abstract
• 1 Emergence of PPRV
• 2 Host Range
• 3 Current Distribution
• 4 Virus Transmission and Spread
• 5 Molecular Biology of the Virus
• 6 Vaccines
• 7 Diagnostics for PPRV
• 8 Toward the Global Control and Eradication of PPR
• 9 Areas for Future Research

Chapter Two: Cell-to-Cell Spread of HIV and Viral Pathogenesis

• Abstract
• 1 Introduction
• 2 T-Cell Virological Synapse
• 3 Infectious Synapses and trans-Infection
• 4 Role of Cell-to-Cell Infection During Sexual Transmission
• 5 Conclusions

Chapter Three: Future Scenarios for Plant Virus Pathogens as Climate Change Progresses

• Abstract
• 1 Introduction
• 2 General Considerations
• 3 Direct Climate Effects
• 4 Indirect Climate Effects
• 5 Implications for Control
• 6 Information Gaps and Deficiencies
• 7 Conclusions
• Acknowledgments

Chapter Four: Autophagy and Mammalian Viruses: Roles in Immune Response, Viral Replication, and Beyond

• Abstract
• 1 The Autophagic Machinery in Mammalian Cells
• 2 Autophagy in Innate Immune Control of Virus Infections
• 3 Adaptive Antiviral Immune Responses Mediated by Autophagy
• 4 Autophagy Manipulation by Viruses
• 5 Unconventional Use of Autophagy Proteins
• 6 Role of Autophagy in Virus Particle Release
• 7 Conclusions and Future Directions
• Acknowledgments

Chapter Five: Historical Perspective: What Constitutes Discovery (of a New Virus)?

• Abstract
• 1 The Unique Role of Ultrafiltration in the Development of Virology
• 2 Proof That the Infectious Agent Is a Virus
• 3 The Contemporary Sense of the Identity of a New Virus
• 4 Proof That the New Virus Is the Etiologic Agent of the Disease (“Proof of Causation”)
• 5 The Discovery and Discoverers of New Viruses
• Acknowledgment