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Aging and the Kidney

Possible Mechanisms, Consequences, and Management Strategies

  • 1st Edition - July 1, 2026
  • Latest edition
  • Editors: Stephen Fadem, Ahmed Arslan Yousuf Awan, Emaad Abdel-Rahman
  • Language: English

Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and lo… Read more

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Description

Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The kidney contains both regenerative and terminally differentiated cells, serving as a crossroad for vascular and inflammatory processes, and regulates many conditions associated with chronic, progressive, and debilitating disease. Efforts to slow the decline in kidney function can enhance quality of life in the aging population. This book is organized into three main parts: mechanisms of the aging kidney, clinical consequences, and management and prevention. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed.

The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease. The final part focuses on diagnostic, management, and prevention strategies. The common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. Kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients. This comprehensive work serves as a valuable resource for understanding how aging affects systemic health and offers potential pathways to enhance lifespan and well-being in elderly patients.

Key features

  • Covers histological, structural, physiological, and functional changes leading to a decline in kidney function with aging
  • Summarizes the most up-to-date research on the kidney’s impact on health and lifespan
  • Addresses common myths regarding kidney disease in the elderly
  • Provides guidance on diagnostic, management, and prevention strategies in kidney health and disease for the aging patient

Readership

Researchers and clinicians specifically in the fields of geriatrics, gerontology, nephrology or those dealing with elderly patients

Table of contents

PART 1 – Mechanisms of aging in the kidney

1. Structure and physiological changes in the aging kidney

2. Models of aging kidney

3. Molecular mechanisms of aging in the kidney

4. The podocyte

5. Epigenetics and the kidney

6. The influence of acute kidney injury on aging

7. Nutritional considerations and aging

8. Proteomics in the kidney

PART 2 – Clinical Consequences

9. Functional impairment in elderly CKD patients

10. Unique characteristics of kidney diseases in the elderly

PART 3 – Management and Prevention

11. How to make a diagnosis of CKD in an elderly individual, since a decline in GFR is expected with normal healthy aging

12. Myths about CKD in the elderly

13. The living donor and aging

14. CNS limitations in the elderly kidney patient

15. Cancer and the kidney in an elderly individual

16. CKD and cardiovascular diseases (CVD) in an elderly individual

17. Benefits of RAAS blockage

18. Newer drugs and CKD

19. Drugs to avoid with geriatric kidney disease

20. Conservative management of ESRD

Product details

  • Edition: 1
  • Latest edition
  • Published: July 1, 2026
  • Language: English

About the editors

SF

Stephen Fadem

Stephen Z Fadem has been in clinical practice since 1978 and is currently a Clinical Professor of Medicine at Baylor College of Medicine. During his career, he has been involved in both teaching and clinical research. Dr. Fadem’s special interests revolve around how the morbidities associated with advancing kidney disease lead to sarcopenia and frailty. He is currently in the process of planning a large fall prevention research project for dialysis patients. He has participated in 44 clinical trials and currently has 93 publications and book chapters, as well as 38 patient education articles. Dr. Fadem is the recipient of several national awards. He has been recognized as a Top Doctor by Castle-Connolly for several years, has won the Medal of Excellence from AAKP, and the Presidents Lifetime Achievement Award.

Affiliations and expertise
Clinical Professor of Medicine, Baylor College of Medicine, USA

AA

Ahmed Arslan Yousuf Awan

Dr. Ahmed Arslan Yousuf Awan is a practicing nephrologist and Assistant Professor, Department of Medicine, Nephrology and Abdominal Transplantation at the Baylor College of Medicine. Dr. Awan is founder and director of Hepatorenal services and site director for Nephrology fellowships at Baylor St. Luke’s Medical Center (BSLMC) and is the elected faculty senator for BSLMC. He is winner of Faculty of the Year award, Leadership award, Excellence in Patient Care award and has received the Houstonia top doctors award for 3 consecutive years. He is the principal investigator for an ongoing study regarding racial disparities in living kidney donation and a member of the KDIGO focused group that recently published updated guidelines regarding management of hepatitis C and CKD. He is on the faculty at Baylor College of Medicine as well as a lead in innovative national and international courses like Nephrology Business Leaders University (NBLU) and the GlomCon Fellowship.

Affiliations and expertise
Assistant Professor, Department of Medicine, Nephrology and Abdominal Transplantation, Baylor College of Medicine, USA

EA

Emaad Abdel-Rahman

Emaad M Abdel-Rahman, MD, PhD, has been a nephrologist for over three decades specializing in caring for elderly patients with kidney disease, dialysis patients, and patients with acute and chronic kidney diseases. He is director of the UVA Kidney Center Clinic and main hemodialysis unit and leads one of the few home hemodialysis units in the country. Abdel-Rahman has been actively involved in clinical research throughout his career, including both investigator-initiated and industry-related trials. Dr Abdel-Rahman is a recipient of the UVA School of Medicine Dean’s Award for Clinical Excellence and the Department of Medicine Mentoring Excellence award. He has served on the Advisory Geriatric Nephrology Committee and as a member of the steering committee of the Kidney Health Initiative at the American Society of Nephrology. He now serves as interim director of the Nephrology Clinical Research Center within the UVA Division of Nephrology.

Affiliations and expertise
Director or the UVA Kidney Center Clinic and interim Director of the Nephrology Clinical Research Center, UVA Division of Nephrology, USA