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Angiotensin

From the Kidney to Coronavirus

  • 1st Edition - February 20, 2023
  • Latest edition
  • Editor: Paul M. Pilowsky
  • Language: English

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health a… Read more

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Description

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more.

The final part of the book is dedicated to angiotensin’s role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book’s complete coverage of organ systems and diseases where Angiotensin plays a key role.

Key features

  • Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19
  • Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction
  • Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels

Readership

Biological and biomedical sciences researchers at PhD level and above, Research Physicians in areas where Angiotensin plays a key role in disease states (cardiology, nephrology, cancer research)

Table of contents

Foreword

Paul M. Pilowsky

1. Regulation of sympathetic nerve activity by the central angiotensin system in heart failure

Rohit Ramchandra and Julia Shanks

2. The contribution of angiotensin peptides to cardiovascular neuroregulation in health and disease

Ewa Krystyna Szczepańska-Sadowska, Tymoteusz Żera and Agnieszka Cudnoch-Jedrzejewska

3. Renin Angiotensin System and inflammation

Ana Cristina Simões e Silva, Leticia Bitencourt, Juliana Lacerda de Oliveira Campos, Bruna Luisa Fischer, Pedro Alves Soares Vaz de Castro and Stephanie Bruna Camilo Soares de Brito

4. Targeting Renin Angiotensin System: A strategy for drug development against neurological disorders

Bharat Bhusan Subudhi and Pratap Kumar Sahu

5. Pharmacology of Angiotensin in renovascular system

Gaaminepreet Singh, Kirti Gupta, Newly Bagang, Sandeep Arora, Onkar Bedi, Manish Kumar and Shubham Yadav

6. The Role of Angiotensins in the Pathophysiology of Human Pregnancy

Kirsty G. Pringle, Eugenie Lumbers, Saije Morosin and Sarah Delforce

7. Hematopietic bone marrow renin-angiotensin system in health and disease

Ibrahim Celalettin Haznedaroglu and Umit Malkan

8. Angiotensin II as a mediator of renal fibrogenesis

Gunter Wolf and Ivonne Löffler

9. ANGIOTENSIN AND ATHEROSCLEROTIC VASCULAR DISEASE

Delia Salaru, Cristina Adam, Dragos Marcu, Radu Sascau and Cristian Statescu

10. ACE2 in pulmonary diseases

Hongpeng Jia and Qing Lin

11. Renin Angiotensin Aldosterone System Inhibitors. New and Old Approaches

Carlos Maria M Ferrario, Jessica L. VonCannon, Kendra N. Wright and Sarfaraz Ahmad

12. Aspects of the Intracellular Renin-Angiotensin System

Mark Chappell, Liliya Yamaleyeva, Hossam Shaltout and TanYa Gwathmey-Williams

13. Drugs affecting the angiotensin system in COVID19

Fouad M. Zouein

14. ANGIOTENSIN II AND ITS ACTION WITHIN THE BRAIN DURING HYPERTENSION

Srinivas Sriramula and Vinicia Campana Biancardi

15. Morphological Aspect of the Angiotensin Converting Enzyme ACE2

Ken Yoshimura, Yasuo Okada, Shuji Toya, Shin-Ichi Iwasaki and Tomoichiro Asami

16. Angiotensin in the eye

Dulce Elena Casarini Sr.

17. Brain renin-angiotensin system in the injured brain: The role of astrocytes and microglia

Alberto Javier Ramos

18. Angiotensin and COVID19

Gaetano Alfano

19. Transgenic animal models for the functional analysis of ACE2

Michael Bader and Natalia Alenina

20. Role of Angiotensin in Different Malignancies

Alok Chandra Bharti, Manoj Kumar Kashyap, Anjali Bhat, Divya Janjua, Rashmi Rao, Kulbhushan Thakur, Arun Chhokar, Nikita Aggarwal, Joni Yadav, Tanya Tripathi, Apoorva Chaudhary and Anna Senrung

21. ACE2/Angiotensin-(1-7)/Mas Receptor Axis in the Central Nervous System: Physiology and Pathophysiology

Aline Miranda, Antonio Lucio Teixeira, Natalia Rocha, Milene Rachid and Eliana Toscano

22. Therapeutic Potential of Angiotensin-(1-7)

Patricia Elizabeth Gallagher, E. Ann E. Tallant and Ana Clara Melo

23. Angiotensin and Pain

Cristian Acosta, Alicia Seltzer, Sean Patterson and Susana Valdez

24. Renin-angiotensin system and emotional stress

Marco Antônio Peliky Fontes, Ana Cristina Simões e Silva and Lucas Kangussu

25. Angiotensins in obesity: focus on white adipose tissue

Eliete Dalla Corte Frantz, Dangelo Magliano, Beatriz Alexandre-Santos and Vinícius Sepulveda-Fragoso

26. Angiotensin in the gut: role in inflammatory bowel disease

Yan Chun Li

27. The Renin-Angiotensin System in gastrointestinal functions

Maria Grazia Zizzo and Rosa Serio

28. Angiotensin in shock

Emily See, Yugeesh Lankadeva, Rinaldo Bellomo, Clive May

29. Angiotensin II and astrocytes: relevance to psychiatric disorders

Claudia Bregonzio

30. Ang II in the kidney in polycystic kidney disease

Jacqueline Kathleen Phillips, Sheran Li and Shabarni Gupta

31. The Role of Angiotensin Peptides in the Brain During Health and Disease

DAVID WONG ZHANG, T. Michael De Silva and Christopher Sobey

Review quotes

“…an excellent resource in the series on Molecular Mediators in Health and Disease, covering how cells communicate from the perspective of individual mediators… [with] interesting details on the renin- angiotensin-aldosterone system (RAAS) and development of drugs that block the formation of angiotensin to manage hypertension; the detection of functional renin-angiotensin systems existing locally in the tissue; the discovery of angiotensin (1-7); and the identification of angiotensin- converting enzyme 2 (ACE2) as a receptor for the coronavirus that causes COVID-19…. [T]he book is very much needed…. [and] includes several colored illustrations which facilitate easier understanding of this complex subject…. [A]n excellent reference for students, researchers in life sciences, and clinicians, especially nephrologists and others interested in the diverse functions of the angiotensin system.” —©Doody’s Review Service, 2023, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

Product details

  • Edition: 1
  • Latest edition
  • Published: February 24, 2023
  • Language: English

About the editor

PP

Paul M. Pilowsky

Paul M Pilowsky began BMedSci(Hons), BMBS, PhD his career as a graduate student investigating, inter alia, the role of brainstem and spinal cord pathways in the control of blood pressure with a focus on serotonin. His work has now been cited more than 5000 times and published in major Journals including the Journal of Neuroscience, the Journal of Comparative Neurology and the British Journal of Pharmacology. A hallmark of his work has been the adoption of, and combination of, novel approaches to address difficult questions. He pioneered the use of combining single cell electrophysiology in vivo with immunohistochemistry. His development of isotype selective monoclonal antibodies to phosphorylated tyrosine hydroxylase enabled the detection of tyrosine hydroxylase positive presympathetic neurons in the brainstem that had become excited. He was responsible for the initial development of a new medical school at Macquarie University in Sydney. His service to Neuroscience was recognised by the award of the Australian Neuroscience Medal. He mentored 26 graduate students to on-time completion, and mentored 24 post-Doctoral Fellows, many of whom now have their own established careers. In imagining this book, it was felt that a departure from the usual highly focussed text would be of interest. Hence, a multi-Author volume has been created that reveals the multiple facets of a neurotransmitter with very broad actions.
Affiliations and expertise
Professor of Physiology, University of Sydney, Australia

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