Skip to main content

Applied Multivariate Statistical Analysis in Medicine

  • 1st Edition - August 21, 2024
  • Latest edition
  • Author: Jingmei Jiang
  • Language: English

Applied Multivariate Statistical Analysis in Medicine provides a multivariate conceptual framework that allows readers to understand the interconnectivity and interrela… Read more

Data Mining & ML

Unlock the cutting edge

Up to 20% on trusted resources. Build expertise with data mining, ML methods.

Description

Applied Multivariate Statistical Analysis in Medicine provides a multivariate conceptual framework that allows readers to understand the interconnectivity and interrelations among variables, which maintains the intrinsic precision of statistical theories. With a strong focus on the fundamental concepts of multivariate statistical analysis, the book also gives insight into the applications of multivariate distribution in biomedical fields.

In 14 chapters, Applied Multivariate Statistical Analysis in Medicine covers the main topics of multivariate analysis methods widely used in health science research. The content is organized progressively from fundamental concepts to sophisticated methods. It begins with basic descriptive statistics in multivariate analysis and follows with parameter estimation, in addition to the hypothesis testing of a multivariate normal distribution, which has heavy applications in biomedical fields where the relationships among approximately normal variables are of great interest. Keeping mathematics to a minimum, considerable emphasis is placed on explanations and real-world applications of core principles to maintain a good balance between introducing theory and cultivating problem-solving skills. This book is a very valuable reference text for clinicians, medical researchers, and other researchers across medical and biomedical disciplines, all of whom confront increasingly complex statistical methods during the analysis and presentation of their results.

Key features

  • Gives understanding and mastering of the multivariate analysis techniques in the medical sciences
  • Maintains a balance between the introduction of statistical analysis theory and the cultivation of practical skills
  • Exposes a variety of well-designed real-life cases that integrate concepts and analytical techniques
  • Includes substantive exercises, online coding sources, and case discussions to solidify a conceptual understanding

Readership

Researchers and students in biostatistics clinicians, medical researchers, and other researchers across medical and biomedical disciplines

Table of contents

1. Overview of multivariate statistical analysis

1.1 Introduction

1.2 Application of multivariate statistical analysis

1.3 Structure of multivariate data

1.4 Descriptive statistics of multivariate data

1.5 Statistical distance

1.6 Statistical software

1.7 Problems


2. Multivariate normal distribution

2.1 Introduction

2.2 Distributions of random vectors

2.3 Numerical characteristics of random vectors

2.4 Multivariate normal distribution

2.5 Parameter estimation of the multivariate normal distribution

2.6 Calculation of the reference region

2.7 Detecting outliers

2.8 Summary

2.9 Problems


3. Hypothesis testing for the parameters of multivariate normal populations

3.1 Introduction

3.2 Distributions of several important statistics

3.3 Hypothesis testing

3.4 Multivariate analysis of variance

3.5 Testing for the homogeneity of covariance matrices

3.6 Data transformation

3.7 Summary

3.8 Problems


4. Multivariate linear regression

4.1 Introduction

4.2 Classical multivariate linear regression model

4.3 Hypothesis tests for models and regression coefficients

4.4 Evaluation of model fit and variable selection

4.5 Diagnosis and treatment of multicollinearity

4.6 Other issues in multivariate linear regression

4.7 Summary

4.8 Problems


5. Generalized linear models

5.1 Introduction

5.2 Overview of generalized linear models

5.3 Data representation of generalized linear models

5.4 Distribution of response variables

5.5 Exponential family and generalized linear models

5.6 Parameter estimation for generalized linear models

5.7 Hypothesis testing for generalized linear models

5.8 Goodness-of-fit test of generalized linear models

5.9 Application of generalized linear models

5.10 Summary

5.11 Problems


6. Logistic regression

6.1 Introduction

6.2 Logit behind logistic regression models

6.3 Binary logistic regression

6.4 Logistic regression for matched case-control studies

6.5 Logistic regression for multinomial outcomes

6.6 Logistic regression for ordinal outcomes

6.7 Other issues for logistic regression

6.8 Summary

6.9 Problems


7. Survival analysis

7.1 Introduction

7.2 Overview for survival analysis

7.3 Modeling the hazard function

7.4 Exponential model

7.5 Weibull model

7.6 Cox proportional hazard model

7.7 Extensions to the Cox proportional hazard model

7.8 Summary

7.9 Problems


8. Principal component analysis

8.1 Introduction

8.2 Population principal components

8.3 Sample principal components

8.4 Steps of principal component analysis

8.5 Application of principal component analysis

8.6 Summary

8.7 Problems


9. Factor analysis

9.1 Introduction

9.2 Exploratory factor analysis

9.3 Confirmatory factor analysis

9.4 Steps of factor analysis

9.5 Other issues in factor analysis

9.6 Summary

9.7 Problems


10. Canonical correlation analysis

10.1 Introduction

10.2 Review of correlation

10.3 Population canonical correlations

10.4 Sample canonical correlations

10.5 Canonical redundancy analysis

10.6 Other issues in canonical correlation analysis

10.7 Summary

10.8 Problems


11. Cluster analysis

11.1 Introduction

11.2 Measures of similarity

11.3 Definition and characteristics of clusters

11.4 Hierarchical clustering methods

11.5 Dynamic clustering method

11.6 Ordered object clustering

11.7 Other issues in cluster analysis

11.8 Summary

11.9 Problems


12. Discriminant analysis

12.1 Introduction

12.2 Discrimination using the mahalanobis distance

12.3 Fisher discriminant

12.4 Bayes discriminant

12.5 Stepwise discriminant

12.6 Other issues for discriminant analysis

12.7 Summary

12.8 Problems


13. matrix algebra

13.1 Introduction

13.2 Basic concept of a vector

13.3 Basic concept of a matrix

13.4 Determinant, inverse, and rank of a matrix

13.5 Eigenvalue, eigenvectors, and trace of a matrix

13.6 Quadratic forms, spectral decomposition, and positive definite matrix

13.7 Elimination transformation

13.8 Derivative of the matrix

13.9 Summary

13.10 Problems

Product details

  • Edition: 1
  • Latest edition
  • Published: August 21, 2024
  • Language: English

About the author

JJ

Jingmei Jiang

Jingmei Jiang, Professor of Biostatistics in the Department of Epidemiology and Biostatistics, Institute of Basic Medical Research, Chinese Academy of Medical Sciences and School of Basic Medical Research, Peking Union Medical College, China. Doctoral degree from Peking Union Medical College. As the current Head of Statistics Department, she has been teaching statistics for more than 30 years and has gained much experience in teaching several biostatistics courses to undergraduate and graduate students at PUMC. She has completed four textbooks (one in English) as Editor-in-Chief and five monographs (four in English) as Editor. Since 2000, she has authored more than 100 scientific papers, including more than 70 peer-reviewed research papers as first author or corresponding author. Although the author has a broad research interest in the application of biostatistical methods in medical research, she mainly devotes herself to two research fields: population-based cancer research and clinical patient safety research.
Affiliations and expertise
Professor of Biostatistics, Department of Epidemiology and Biostatistics, Institute of Basic Medical Research, Chinese Academy of Medical Sciences and School of Basic Medical Research, Peking Union Medical College, Beijing, China

View book on ScienceDirect

Read Applied Multivariate Statistical Analysis in Medicine on ScienceDirect