Benzodiazepine-Based Drug Discovery
- 1st Edition - August 16, 2022
- Latest edition
- Authors: Farzad Zamani, Esmail Doustkhah
- Language: English
Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structure… Read more
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Description
Description
Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry.
The importance of these privileged pharmacophores is not limited to the treatment of psychotic disorders because minor changes in the structures can generate various biological activities. They represent a wide range of therapeutic functions such as anticonvulsant, antianxiety, anti-depressant, antiviral, anti-HIV, anti-inflammatory, anticoagulant, anti-obesity, endothelin antagonist, cholecystokinin antagonist, and vasopressin receptor antagonist activities.
Key features
Key features
- Presents detailed coverage of chemical structures and practical synthetic methods of benzodiazepines and benzothiazepines in drug discovery
- Compiles detailed in vivo and in vitro biological activity data of 1,4-benzodiazepine- and 1,5-benzodiazepine-based drugs that will help researchers design and develop innovative drugs
- Discusses promising avenues and potential challenges in the development of new benzodiazepines and benzothiazepines in medicinal drug synthesis
Readership
Readership
Researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry
Table of contents
Table of contents
1. An Introduction to Benzodiazepines
2. Chemical Structure of 1,4-Benzodiazepines
3. Synthesis of 1,4-Benzodiazepines
4. Biological Behavior of 1,4-Benzodiazepines
5. Pharmaceutical Applications of 1,4-Benzodiazepines
5.1- Short-acting Benzodiazepines
Midazolam (Versed)
Alprazolam (Xanax)
Triazolam (Halcion)
Clorazepate (Tranxene)
5.2. Intermediate-acting Benzodiazepines
Estazolam (ProSom)
lorazepam (Ativan)
Temazepam (Restoril)
5.3. Long-acting Benzodiazepines
Clonazepam (Klonopin)
Chlordiazepoxide (Librium)
Flurazepam (Dalmane)
Diazepam (Valium)
Quazepam (Doral)
6. Chemical Structure of 1,5-Benzodiazepines and 1,5-Benzothiazepines
7. Synthesis of 1,5-Benzodiazepines and 1,5-Benzothiazepines
8. Biological Behavior of 1,5-Benzodiazepines and 1,5-Benzothiazepines
9. Pharmaceutical Applications of 1,5-Benzodiazepines
Clobazam (Onfi)
10. Pharmaceutical Applications of 1,5-Benzothiazepines
10.1. Diltiazem
10.2. Clentiazem
10.3. Thiazesim
10.4. Quetiapine
10.5. Clothiapine
Product details
Product details
- Edition: 1
- Latest edition
- Published: August 22, 2022
- Language: English
About the authors
About the authors
FZ
Farzad Zamani
ED