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Biomarkers in Kidney Transplantation

Clinical Aspects and Laboratory Determinations

  • 1st Edition - October 17, 2025
  • Latest edition
  • Editors: Dr Smita Pattanaik, Dr Ashish Sharma
  • Language: English

Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection… Read more

Description

Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.

Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

Key features

  • Includes comprehensive coverage on all available biomarkers to predict organ rejection
  • Provides guidance on how to interpret test results of all available biomarkers
  • Covers possible sources of errors in measuring biomarkers to eliminate issues of interference

Readership

Pathologists, clinical pharmacologists and clinical laboratory scientists, physicians involved in organ transplantation, immunologists and transplant surgeons, etc., Nurse practitioners and clinical pharmacists working in organ transplant divisions, and scientists working in diagnostic industries to develop commercially viable assays for new transplant biomarkers

Table of contents

1. Organ transplantation: past, present, and future
Shivakumar S Patil, Arun Panjathia, Sai Praneeth Reddy and Mukut Minz

2. Trends in kidney transplantation
Ashish Sharma and Amit Sharma

3. Immunobiology in kidney transplantation
Vivek Kute, Sudeep Desai and Sanshriti Chauhan

4. Immunosuppression in kidney transplantation
Abhinav Seth and Jasmine Sethi

5. Challenges in the therapeutic drug monitoring of immunosuppressants
Wanzhu Zhao and Uwe Christians

6. Overview of biomarkers in kidney transplantation
Austin D. Schenk, Navdeep Singh and Manjit Kaur

7. Biomarkers for ischemia reperfusion injury and delayed graft function
Milind Mandwar and Sarbpreet Singh

8. Biomarkers of renal transplant rejection: yesterday, today, and tomorrow
Ranjana Walker Minz, Jagdeep Singh and Deepesh B Kenwar

9. Biomarkers predicting the response to immunosuppressant therapy
Mercè Brunet and Olga Millán

10. Biomarkers of recurrent disease after kidney transplantation
Niveditha Girimaji, Raja Ramachandran, Smita Divyaveer and Harbir Singh Kohli

11. Biomarkers of tolerance in renal transplantation
Ravi Dhital and Tara K Sigdel

12. Biomarkers for detecting opportunistic infections in renal transplant recipients
Suryasnata Das and Manisha Biswal

13. Biomarkers for detecting nephrotoxicity due to immunosuppressant drugs
Sourabh Sharma and Vivek Kute

14. Biomarkers for drug development in kidney transplantation
Smita Pattanaik and Teun van Gelder

15. Commercially available biomarker tests in kidney transplantation
Kamisha L. Johnson-Davis

16. The unmet needs, current challenges and future directions for biomarkers in renal transplantation
Smita Pattanaik and Teun van Gelder

Product details

  • Edition: 1
  • Latest edition
  • Published: October 24, 2025
  • Language: English

About the editors

DP

Dr Smita Pattanaik

Dr. Smita Pattanaik is a physician-scientist involved in teaching postgraduate students of clinical pharmacology and clinical patient care services, focusing on the delivery of precision medicine in clinics through therapeutic drug monitoring, pharmacogenomics, and model-informed precision dosing. Her research group, the Translational Pharmacology Laboratory, comprises clinicians, clinical scientists, and basic scientists. The goal is bedside-to-bench and bench-to-bedside translation involving immunosuppressant drugs (ISDs), the repositioning of drugs as anticancer agents, and collaborative clinical trials. Most of the current projects focus on organ transplantation, autoimmune diseases, and cancer.
Affiliations and expertise
Professor of Clinical Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

DS

Dr Ashish Sharma

Ashish Sharma is a highly experienced transplant surgeon. He has more than 200 publications in national and international journals. He has been instrumental in starting academic training programs in kidney and pancreas transplant at PGIMER. Under his leadership, the department has been able to establish a pancreas transplant program, donation after cardiac death, along with a comprehensive surveillance and interventional vascular access program. He has been awarded by the Ministry of Health and the Indian Society of Organ Transplant for his exemplary services in transplant.
Affiliations and expertise
Professor and Head, Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research Chandigarh, India

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