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Cholinergic Involvement in Neurodegenerative Diseases

  • 1st Edition, Volume 211 - May 9, 2025
  • Latest edition
  • Editor: A. Claudio Cuello
  • Language: English

Cholinergic Involvement in Neurodegenerative Diseases, Volume 211 reviews cholinergic function in the brain as it relates to Neurodegenerative disorders. Coverage includes Alzhei… Read more

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Description

Cholinergic Involvement in Neurodegenerative Diseases, Volume 211 reviews cholinergic function in the brain as it relates to Neurodegenerative disorders. Coverage includes Alzheimer’s, dementia, Down Syndrome, Parkinson’s, Huntington’s, ALS, and more. In addition, the anatomy of the cholinergic system is described as well as the distribution and function of receptors.

Key features

  • Discusses the cholinergic system as it relates to neurodegenerative diseases
  • Encompasses broad, comprehensive content on dementia, Alzheimer’s, Parkinson’s, Huntington’s, ALS and more
  • Covers anatomy and the distribution/function of receptors

Readership

Researchers and practitioners in clinical neurology

Table of contents

1. The history of the CNS cholinergic transmission

2. Organization of the basal forebrain cholinergic system in the human brain

3. The cholinergic synapses

4. Nicotinic acetylcholine receptors in the brain

5. Cognition and modulation of the cholinergic system

6. The involvement of the cholinergic system in Alzheimer disease

7. Structural changes to the basal forebrain cholinergic system in the continuum of the Alzheimer’s pathology

8. The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology

9. NGF based cholinergic therapies in Alzheimer disease

10. Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission

11. Cholinergic therapy in Alzheimer’s disease

12. CNS muscarinic receptors agonists in Alzheimer’s disease treatment

13. The Cholinergic system in down syndrome

14. The Cholinergic system in Parkinson disease

15. The Cholinergic system in dementia with Lewy bodies

16. Epilogue. Standing on the shoulders of giants—Charting the future of cholinergic research

Product details

  • Edition: 1
  • Latest edition
  • Volume: 211
  • Published: May 9, 2025
  • Language: English

About the editor

AC

A. Claudio Cuello

A. Claudio Cuello works in the Department of Pharmacology and Therapeutics at McGill University in Montreal, Quebec, Canada.
Affiliations and expertise
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada

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