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Comprehensive Toxicology

  • 4th Edition - September 15, 2025
  • Latest edition
  • Editor: Charlene McQueen
  • Language: English

Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicolog… Read more

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Description

Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.

It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.

Key features

  • Covers both the fundamental principles of toxicology and unique aspects of major organ systems
  • Revised edition with new chapters on topics such as new approaches in testing strategies, novel in vitro models such as organ on a chip, and microphysiological systems to name a few
  • Includes computational approaches, ‘omics’, new approaches to risk and safety assessment, harmonization, artificial intelligence, and the microbiome
  • Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts

Readership

Graduate and postgraduate students, academic researchers, faculty in toxicology, medical toxicology and pharmacology.Professionals in medical practices, the chemical industry, food science research, environmental research and consulting, forensic science, regulatory agencies, patent and environmental law, and occupational health and safety

Table of contents

Comprehensive Toxicology will comprise of around 400 chapters, organized across the 14 sections listed below:

1. General Principles

2. Hepatic Toxicology

3. Reproductive and Endocrine Toxicology

4. Developmental Toxicology

5. Nervous System and Behavioral Toxicology

6. Carcinogenesis

7. Cellular and Molecular Toxicology

8. Toxicology Testing and Evaluation

9. Biotransformation

10. Immune System Toxicology

11. Hematopoietic Systems Toxicology

12. Cardiovascular Toxicology

13. Gastrointestinal and Renal Toxicology

14. Respiratory Toxicology

Product details

  • Edition: 4
  • Latest edition
  • Published: September 15, 2025
  • Language: English

About the editor

CM

Charlene McQueen

Charlene A. McQueen is a Professor in the Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona. Until January 2017, she was a Senior Scientist at the National Health Effects Research Laboratory of the USEPA. She served as the Director of the Integrated Systems Toxicology Division (2011-2016). Prior to that, she held positions at the Harrison School of Pharmacy, Auburn University (2007-2011) and the Department of Pharmacology and Toxicology at the University of Arizona (1990-2007). Dr McQueen received a M.S. in Pharmacology from New York University and Ph.D. in Human Genetics from the University of Michigan. Her work is in the areas of pharmacogenomics, toxicogenomics and chemical carcinogenesis. She has a particular interest in the genetic basis for response to xenobiotics. Her work with the arylamine N-acetyltransferase polymorphism has demonstrated that this genetic variation can affect drug efficacy as well as toxicity of aromatic amines and hydrazines. She was the Editor-in-Chief of the second edition of Comprehensive Toxicology and is continuing in that position for the third edition to be published in 2017. Dr McQueen is an American Association for the Advancement of Science (AAAS) Fellow and a Fellow in the Academy of Toxicological Sciences (ATS). Dr McQueen received the Society of Toxicology (SOT) Public Communications Award, the SOT AstraZeneca Traveling Lectureship Award and has served on numerous SOT committees. Dr McQueen was on the Environmental Health Sciences Committee of the National Institute of Environmental Health Sciences, the Board of Scientific Councilors of the National Toxicology Program and the National Institutes of Health Cancer Etiology Study Section. She is a member of the Editorial Board of the Reference Modules in Biomedical Sciences (Elsevier). Dr McQueen is a member of the Health and Environmental Sciences Institute (HESI) Board of Trustees, serving as the Board Secretary (2012-2017) and is currently Vice-president elect (2017-2018). Her current research interests include the discovery and development of Adverse Outcome Pathways (AOPs) for fatty liver disease and carcinogenesis as well as the role of the microbiome in xenobiotic biotransformation.
Affiliations and expertise
Professor, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, USA

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