Cryo-EM Methods and Management
- 1st Edition - October 1, 2026
- Latest edition
- Editors: Edward T. Eng, Jake D. Johnston, Alex de Marco
- Language: English
Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern… Read more
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Description
Description
Key features
Key features
- Offers a comprehensive overview of the latest advances and methodologies in cryo-EM
- Includes guidance on sample preparation, data collection and data processing
- Shares insights into setting up, maintaining, and managing a cryo-EM facility
- Considers future developments in the field
Readership
Readership
Table of contents
Table of contents
1. An overview of cryo-EM
Part II: Cryo-EM workflows
2. Cryo-EM sample handling and preparation
3. Data collection and hardware
4. Data processing and visualization pipelines
Part III: Infrastructure and community building
5. Facilities, user base and centralized resources
6. Monitoring and proactive maintenance
7. Data sharing and standards
8. Training and development
Part IV : Concluding Perspectives
9. Prospective advances in cryo-EM
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 1, 2026
- Language: English
About the editors
About the editors
EE
Edward T. Eng
Dr. Edward T. Eng is a senior scientist at the Simons Electron Microscopy Center, and the manager of the National Center of CryoEM Access and Training, at New York Structural Biology Center. Dr. Eng has been a Research Topic Editor at Frontiers in Molecular Biosciences, Structural Biology and a Special Issue Editor at the International Journal of Molecular Sciences. He is the author or co-author of over 100 scientific works in various journals and his major research interest is application of electron microscopy (EM) to biomedical research by providing expertise and resources for understanding both molecular and cellular structures.
JJ
Jake D. Johnston
Jake D. Johnston is a Ph.D. student at Columbia University's Physiology department. He is working in the de Marco lab at the Simons Electron Microscopy Center where his main interests are involved with method development for high-resolution in-situ cryo-electron tomography. At SEMC, he gained expertise on cryo-ET sample preparation, data collection, and processing. Before pursuing a doctoral degree, he obtained his master’s in biochemistry under Dr. Stephan Sprang at the University of Montana, and in collaboration with Dr. Wah Chiu’s group at Stanford University where his work focused on elucidated the structure of G-protein complexes.
AM
Alex de Marco
Dr. Alex de Marco is the Director at the Simons Electron Microscopy Center and is a distinguished electron microscopist known for innovative research in the field of cryo-electron tomography. He earned his PhD from EMBL and Heidelberg University (Germany) specializing in cryo-electron tomography and image processing. His work resulted in the first structural description of the viral maturation in HIV-1 and the first sub-nm structure ever solved using sub-tomographic averaging. He then worked as Product Manager at FEI Company (now Thermo Fisher) and introduced solutions for cryo-FIB milling and correlative microscopy. In 2016 he returned to academic research starting his group at Monash University. His research focused on methods and technology development for high resolution in situ cryo-electron microscopy while maintaining an interest in the development of non-linear micro-optics. In 2023, he became director of the Simons Electron Microscopy Center at the New York Structural Biology Center.