Current Topics in Cellular Regulation

List of Contributors

Preface

Contents of Volume 1

DPN-Linked Isocitrate Dehydrogenase of Animal Tissues

I. Introduction

II. Properties

III. Effect of Nucleotides

IV. Other Activators, Stabilizers, and Inhibitors

V. Control of Mitochondrial Isocitrate Oxidation

References

The Regulation of Biosynthesis of Aromatic Amino Acids and Vitamins

I. Introduction

II. Regulation of the Common Pathway

III. Regulation of the Tryptophan Pathway

IV. Regulation of Phenylalanine and Tyrosine Biosynthesis

V. Regulation of Vitamin Biosynthesis

VI. Conclusion

References

Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues

I. Introduction

II. Feedback Control of Cholesterol Synthesis

III. Feedback Inhibition of Cholesterol Synthesis in the Intestine

IV. The Effect of Fasting upon Cholesterol Synthesis

V. Other Factors Affecting Cholesterol Synthesis

VI. Cancer and the Control of Cholesterol Synthesis

VII. Summary

References

The Biogenesis of Yeast Mitochondria

I. General Physiology and Biochemistry of Saccharomyces cerevisiae

II. Genetic Systems

III. Mitochondrial DNA

IV. Protein Synthesis

References

Note Added in Proof

Fructose 1,6-Diphosphatase from Rabbit Liver

I. Introduction

II. Properties of Purified Liver FDPase

III. Desensitization against Inhibition by AMP

IV. Subunit Structure

V. Number of Binding Sites for Substrate, AMP, and Divalent Cation

VI. Modification of Catalytic Activity at Neutral pH

VII. Discussion

References

The Role of Phosphoribosyltransferases in Purine Metabolism

I. Introduction

II. Properties of Phosphoribosyltransferases

III. Role of Phosphoribosyltransferases in Purine Metabolism

IV. Conclusions

References

Concentrations of Metabolites and Binding Sites. Implications in Metabolic Regulation

I. Introduction

II. Some Metabolic Consequences of Cellular, Subcellular, and Intercellular Compartmentation

III. Metabolites and Binding Sites

IV. Other Factors That Can Affect the Active Concentration of Metabolites

V. Kinetic Problems When [Enzyme] > [Substrate]

VI. Particular Problems When the Substrate Is about as Large or Much Larger than the Enzyme

VII. Final Remarks

References

A Discussion of the Regulatory Properties of Asportate Transcarbamylase from Escherichia coli

I. Introduction

II. Properties of the Catalytic Subunit

III. Properties of the Regulatory Subunit

IV. Arrangement and Interaction of Polypeptide Chains in ATCase

References

Author Index

Subject Index