Current Topics in Cellular Regulation

List of Contributors

Preface

Contents of Previous Volumes

The Regulation of Arginine Metabolism in Saccharomyces Cerevisiae: Exclusion Mechanisms

I. Introduction

II. Inhibition of Ornithine Transcarbamylase by Epiarginase

III. Common Genetic Elements in the Control of Biosynthetic and Degradative Enzyme Synthesis

IV. Conclusions

References

The Lac Repressor

I. Introduction

II. The Repressor Protein

III. Inducer Binding

IV. Operator Binding

V. The Mechanism of Induction

VI. The Operator

VII. Positive Control of the Lac Operon

VIII. The Mode of Action of the Lac Repressor

IX. Generalization

References

L-Glutamate Dehydrogenases

I. Introduction

II. Physical and Chemical Properties of Glutamate Dehydrogenases

III. The Catalytic Reaction

IV. Purine Nucleotide Effect

V. Other Modifiers

VI. Chemical Modification

VII. Metabolic Role of Glutamate Dehydrogenases

VIII. Conclusion

References

Regulation of Fatty Acid Biosynthesis

I. Introduction

II. Acetyl-CoA Carboxylase

III. Fatty Acid Synthetase

References

Kinetic Analysis of Allosteric Enzymes

I. Objective and Limits of the Review

II. Specific Examples

III. Conclusion

References

Phosphorylase and the Control of Glycogen Degradation

I. Introduction

II. Structure, Activity, and Interconversion of Phosphorylase

III. State of Activity of Phosphorylase in Striated Muscle

IV. Phosphorylase Kinase

V. Phosphorylase Phosphatase Structure and Enzymatic Properties

VI. Control of Phosphorylase Activity in an Integrated System

VII. Significance of the Co valent Control of Metabolic Pathways

VIII. Concluding Remarks

References

Author Index

Subject Index