Current Topics in Cellular Regulation

Contents

List of Contributors

Posttranslational NH2-Terminal Aminoacylation

I. Introduction

II. Enzymology of Aminoacyl-tRNA Protein Transferases

III. Analysis of Acceptor Proteins

IV. Analysis of Mutant Phenotypes

V. Discussion

Note Added in Proof

References

The Regulation of Liver Pyruvate Kinase by Phosphorylation-Dephosphorylation

I. Introduction

II. Purification and Some Properties of Liver Pyruvate Kinase

III. Phosphorylation of Liver Pyruvate Kinase in Vitro and Its Effect on the Kinetic Properties of the Enzyme

IV. Phosphorylated Site of Pig Liver Pyruvate Kinase. Subtilisin-Catalyzed Modification

V. The Protein Kinase Reaction with Pyruvate Kinase as Substrate

VI. Phosphorylation of Peptides with Structures Related to the Phosphorylatable Site of Pyruvate Kinase

VII. Dephosphorylation of Pyruvate Kinase with Phosphoprotein Phosphatase

VIII. Rapid Hormonal Regulation of Pyruvate Kinase in Vivo

IX. Conclusions

References

Interconvertible Enzyme Cascades in Metabolic Regulation

I. Introduction

II. Monocyclic Cascade Systems

III. Bicyclic Cascade Systems

IV. Multicyclic Cascade Systems

V. Discussion

References

Metabolic Effects of Fructose in the Liver

I. Introduction

II. Metabolism of Fructose in the Liver

III. Influence of Fructose on the Metabolism of Glycogen

IV. Effect of Fructose on the Catabolism of Purine Nucleotides

V. Influence of Fructose on Lipid Metabolism

VI. Effect of Fructose on Alcohol Metabolism

VII. Concluding Remarks

References

Lactose Operator-Repressor Interaction

I. Introduction

II. The Lac Repressor

III. The Lac Operator

IV. Lactose Operator-Repressor Interaction

V. Models for the Operator-Repressor Interaction and Concluding

Remarks

References

Regulation of Nitrogen Fixation

I. Introduction

II. Regulation of Nitrogenase Activity

III. Regulation of Nitrogenase Synthesis

IV Electron Transport and ATP Production Coupled to N2 Reduction

V. Other Related Regulation

VI. Synopsis

References

The Role of Isozymes in Metabolism: A Model of Metabolic Pathways as the Basis for the Biological Role of Isozymes

I. Introduction

II. The Involvement of Isozymes in Metabolic Regulation

III. The Role of Compartmentation in Metabolic Regulation

IV. A Hypothetical Model of Metabolism: Polyisozymic Complexes

V. Polyisozymic Complexes in Glucose Utilization

VI. Suggested Experimental Tests of the Hypothesis

VII. Concluding Remarks

References

A Molecular Approach to the Complement System

I. Introduction

II. The Complement System

III. Individual Components

IV. Mechanisms of Action

V. Comparisons of Structure and Function

VI. Conclusions and Comments

References

Subject Index

Contents of Previous Volumes