Current Topics in Cellular Regulation

List of Contributors

Guanosine 3′,5′-Monophosphate-Dependent Protein Kinase

I. Introduction

II. Structure and Regulation of G-Kinase

III. Kinetics and Thermodynamics of cGMP Binding to G-Kinase

IV. G-Kinase Activity

V. A Hypothesis Concerning the Structures of G-Kinase and A-Kinase

References

Calmodulin and Its Role in the Second-Messenger System

I. Introduction

II. General Background

III. Activation of Cyclic Nucleotide Phosphodiesterase

IV. Other Regulatory Activities

V. Physiological Roles

VI. Evolutionary Studies

References

Phosphofructokinase: Structure and Function

I. Introduction

II. Structural Properties

III. Polymeric Forms of Phosphofructokinase

IV. Ligand Binding to Phosphofructokinase

V. Allosteric Kinetics

VI. Cold Lability of Rabbit Muscle Phosphofructokinase

VII. Mechanism of the Reaction

VIII. Enzyme Modification

IX. Ligand-Induced Conformational Changes

X. Alternative Modes of Enzyme Regulation

References

Genetic Control of Pentose Phosphate Pathway Enzymes in Drosophila

I. Introduction

II. The Pathway

III. The Structural Genes

IV. Genetic Regulatory Effects

V. Metabolic Regulatory Effects

VI. Concluding Remarks

References

The Regulation and Function of Ornithine Decarboxylase and of the Polyamines

I. Introduction

II. Discrepancies in the Interpretation of the ODC Assay

III. Functions of Polyamines

IV The "Metabolic State" of the Cell and the "External Setting V. The Experimental Systems

VI. Mechanisms That Alter ODC Activity

VII. The Dynamic State of Polyamines in the Normal and Pathologic State

VIII. An Overview of ODC Regulation

IX. Concluding Remarks

References

Biochemistry of Phagocyte Chemotaxis

I. Introduction

II. Comparison of Chemotaxis in Leukocytes and Other Cells

III. Assay of Chemotaxis

IV. The Chemoattractants: Sensing the Signal

V. Transduction of the Chemotactic Signal

VI. Effector Processes: Sustained Locomotion

VII. Concluding Remarks

References

Biochemical Aspects of Neurosecretion: Neurophysin-Neurohypophyseal Hormone Complexes

I. Introduction

II. Neurohormones and Neurophysins: Structural Features

III. Neurophysin-Neurohormone Complexes—In Vitro Studies

IV. Neurophysin-Neurohormone Complexes—In Vivo Studies

V. Concluding Remarks

References

Subject Index

Correction to Volume 9

Contents of Previous Volumes