Current Topics in Cellular Regulation

List of Contributors

Brain Hexokinase, the Prototype Ambiquitous Enzyme

I. Introduction

II. Subcellular Distribution of Hexokinase in Brain Homogenates

III. Cytoplasmic and Mitochondrial Forms of Brain Hexokinase

IV. Mitochondrial Hexokinase

V. Ambiquitous Behavior of Brain Hexokinase

VI. The Molecular Basis for the Specific Binding of Brain Hexokinase by the Outer Mitochondrial Membrane

VII. Hexokinase Activity as a Reflection of Glycolytic Capacity

VIII. Concluding Comments

References

Appendix: Ambiquitous Behavior—A Biological Phenomenon of General Significance?

Appendix References

Compartmentation of Hexokinase and Creatine Phosphokinase, Cellular Regulation, and Insulin Action

I. Introduction

II. Experimental Evidence for Bound Hexokinase as a Compartmental Control Point

III. Bound Creatine Phosphokinase: Experimental Evidence for Compartmentation

IV. The Hexokinase-Mitochondrial Theory of Insulin Action and Hormonal Metabolic Control

References

Cytochrome c Methylation: Enzymology and Biologic Significance

I. Opening Remarks on Protein Methylation

II. Cytochrome c Methylation

III. Closing Remarks

References

Enzyme Organization in the Polyaromatic-Biosynthetic Pathway: The Arom Conjugate and Other Multienzyme Systems

I. Introduction

II. The Polyaromatic-Biosynthetic Multienzyme System

III. Phylogenetic Aspects of Enzyme Organization in the Polyaromatic Pathway

IV. Concluding Remarks

Appendix: Enzyme Organization in Vivo: Some Thermodynamic-Kinetic Perspectives

References

Proteolysis in Bacterial Sporulation

I. Introduction

II. The Proteolytic System of Bacilli

III. Evidence for a Role of Proteolysis in Sporulation

IV. Protein Turnover and Sporulation

V. Proteolytic Modulation of Gene Expression in Sporulation

VI. Inactivation and Modification of Proteins

VII. Proteolysis During Germination

VIII. Concluding Remarks

References

Cyclic Nucleotides in the Central Nervous System

I. Introduction

II. Occurrence of Cyclic Nucleotide-Synthesizing and -Degrading Enzymes in the Mammalian Brain: Occurrence of Phosphorylation-Dephosphorylation Systems That Are Regulated by Cyclic Nucleotides: Regional and Subcellular Localization

III. Evidence for Neuronal or Glial Localization

IV. Evidence for Involvement of Cyclic Nucleotides in Synaptic Transmission: Electrophysiological Studies

V. Neurotransmitter Activation of Adenylate Cyclase

VI. Neurotransmitter-Mediated Increases in cGMP Levels

VII. Regulation of 3′5′-Cyclic Nucleotide Phosphodiesterases

VIII. Regulation of Cyclic Nucleotide-Dependent Protein Kinases

IX. Interactions of Ca2+ with the Cyclic Nucleotide-Dependent Processes

X. Considerations on the Regulatory Organization of the Cyclic Nucleotide Systems

References

Regulation of Oocyte Maturation

I. Introduction

II. Oocytes as Target Cells for Steroid Hormones

III. Calcium Ion as a Positive Effector of Oocyte Maturation

IV. Regulation by Cyclic AMP

V. The Maturation-Promoting Factor and Its Regulation

VI. Current Model of Oocyte Maturation

References

Subject Index

Contents of Previous Volumes