Current Topics in Cellular Regulation

List of Contributors

Glutamine Metabolism in Higher Plants

I. Introduction

II. Enzymes of Glutamine Metabolism

III. The Role of Glutamine in the Flow of Nitrogen

References

Glycogen Synthase and Glycogen Synthase Kinases

I. Introduction

II. Glycogen Synthase

III. Glycogen Synthase Kinases

IV. Multiple Phosphorylation of Glycogen Synthase and Its Effect on Enzymic Properties

V. Regulation of Glycogen Synthase Activity by Covalent Phosphorylation

VI. Conclusion

References

Note Added in Proof

Covalent Modification of Phosphofructokinase by Phosphorylation-Dephosphorylation

I. Introduction

II. Phosphorylation of Liver and Muscle PFK

III. The PFK-Inactivating Enzyme

IV The Physiological Role of PFK Phosphorylation

References

Note Added in Proof

Regulation of Liver 3-Hydroxy-3-Methylglutaryl-CoA Reductase

I. Background

II. Rat Liver Microsomal HMG-CoA Reductase

III. In Vitro Modulation of HMG-CoA Reductase Activity by Covalent Modification

IV. Characterization and in Vitro Modulation of Reductase Kinase

V. In Vivo Modulation of HMG-CoA Reductase Activity

VI. In Vivo Modulation of Reductase Kinase Activity

VII. In Vivo Modulation of the Enzymic Activity and Degree of Phosphorylation of HMG-CoA Reductase

VIII. Bicyclic Cascade of HMG-CoA Reductase and Its Comparison with the Cascade Systems of Glycogen Phosphorylase and Glutamine Synthetase

IX. Current Model for in Vivo Regulation of Cholesterol Biosynthesis

X. Summary

References

Phosphorylation Reactions That Influence the Activity of eIF-2

I. Introduction

II. Phosphorylation of eIF-2α

III. Phosphorylation of eIF-2β

IV. Hypotheses on the Role of eIF-2 Phosphorylation

References

Mono(ADP-Ribosyl)Transferases and Their Effects on Cellular Metabolism

I. Introduction

II. Inhibition of Protein Synthesis by Diphtheria Toxin and Pseudomonas Exotoxin A

III. Activation of Adenylate Cyclase by Choleragen and Escherichia coli Heat-Labile Enterotoxin

IV ADP-Ribosylation of RNA Polymerase in Phage-Infected Escherichia coli

V. ADP-Ribosyltransferase from Turkey Erythrocytes

VI. Summary and Perspectives

References

Does Vanadium Play a Role in Cellular Regulation?

I. Introduction

II. Physiological Effects

III. Metabolic Effects

IV. Effects on Enzyme Activities

V. ATPases

VI. Adenyl Cyclase

VII. NADH Oxidase

VIII. Transport and Intracellular Distribution

IX. Nonenzymic Effects of Vanadate

X. Concluding Remarks

References

Index

Contents of Previous Volumes