Current Topics in Cellular Regulation

Contributors

GTP: A Central Regulator of Cellular Anabolism

I. Introduction

II. In Vitro Studies of GTP Effects on Anabolic Processes

III. Other Regulatory Activities of GTP

IV. In Vivo Studies of GTP Effects

V. Possible Role of GTP in Oncogenesis

VI. The Stringent Response in Bacteria as an Anti-GTP Response

VII. Similarities Among GTP-Binding Proteins

VIII. Control of GTP Levels

IX. General Discussion

References

A Quantitative Approach to Metabolic Control

I. Introduction

II. The Generation and Transmission of Metabolic Fluxes

III. Quantitative Analysis of Regulation

IV. Adenine Nucleotides as Regulators

V. Regulatory Analysis of Branched Systems

VI. Sensitivity and "Control Strength"

VII. Calculations of the Response to a Large Change in Regulator Concentration

VIII. Conclusions

IX. Appendices

References

Inactivation of Rabbit Liver and Muscle Aldolases by Limited Proteolysis by Lysosomal Cathepsin M

I. Introduction

II. Inactivation of Aldolase by Membrane-Bound Lysosomal Proteinases and by Undisrupted Lysosomes

III. Purification of Cathepsin M and Comparison with Cathepsin B

IV. Evidence for the Modification of Liver Aldolases by Cathepsin M in Vivo

V. Regulation of Cathepsin M Activity

VI. Concluding Remarks

References

The Regulatory Functions of Proline and Pyrroline-5-carboxylic Acid

I. Introduction

II. Background

III. The Metabolism of Pyrroline-5-Carboxylate

IV. Redox Regulation and P5C Metabolism

V. P5C as an Effector Molecule

VI. The Proline-P5C Cycle

VII. Implications of the P5C-Mediated Redox Regulation

VIII. Summary and Perspectives

References

Characteristics and Hormonal Regulation of Amino Acid Transport System A in Isolated Rat Hepatocytes

I. Introduction

II. General Characteristics of System A-Mediated Transport

III. Hormonal Regulation of System A

IV. Decay of Stimulated System A Activity

V. Conclusions

References

Index

Cumulative Contributors Index

Contents of Recent Volumes