Current Topics in Cellular Regulation

Control of Metabolism by Dynamic Macromolecular Interactions

I. Introduction

II. Control of Metabolic Pathways

III. Dynamically Organized Enzyme Systems

IV. Energetic Aspects

V. Concluding Remarks

References

Ligand Binding and Multienzyme Complex Formation Between Ornithine Carbamoyltransferase and Arginase from Saccharomyces cerevisiae

I. Introduction

II. Regulation of Arginine Metabolism in Saccharomyces cerevisiae

III. Quaternary Structure of Yeast OTCase and Arginase

IV. Quaternary Structure of the OTCase-Arginase Multienzyme Complex

V. Test for an Ornithine Isosteric Effector Site

VI. Intrinsic and Extrinsic Effects

References

Regulation of Fatty Acid Uptake and Synthesis in Mammary and Adipose Tissues: Contrasting Roles for Cyclic AMP

I. Introduction

II. The Cyclic AMP Economy of Mammary Tissue During Lactation

III. Acute Regulation of Fatty Acid Uptake and Biosynthesis Processes in Lactating Mammary Tissue

IV. Regulation of Acetyl-CoA Carboxylase

V. Cyclic AMP-Dependent Protein Phosphorylation in Mammary Epithelial Cells

VI. Concluding Remarks

References

Structural and Functional Relationships of Guanosine Triphosphate Binding Proteins

I. Introduction

II. The Role of Guanine Nucleotide Binding Proteins in Hormonal Regulation of Adenylate Cyclase Activity

III. The Role of Guanine Nucleotide Binding Proteins in Visual Signal Transmission

IV. Novel Guanine Nucleotide Binding Proteins with Other Functions, and Known Guanine Nucleotide Binding Proteins with Novel Functions

V. G Protein Structures

VI. Summary

References

The Glycogen Storage Disease (gsd/gsd) Rat

I. Introduction

II. The gsd/gsd Rat

III. Perinatal Development in the gsd/gsd Rat

IV. Ultrastructure and Morphometry

V. Metabolism in Aged gsd/gsd Rats

VI. Concluding Remarks

References

Bibliography

Function and Regulation of the Pentose Phosphate Pathway in Brain

I. Introduction

II. Measurement of the Pentose Phosphate Pathway

III. Contribution of the Pentose Phosphate Pathway to Glucose Metabolism

IV. Effects of Activators and Inhibitors on the Pentose Phosphate Pathway in Brain Preparations

V. Developmental Changes in the Activity of the Pentose Phosphate Pathway

VI. Functional Significance of the Pentose Phosphate Pathway in Brain

VII. Summary

References

Regulation of Carotenoid Biosynthesis

I. Introduction

II. Structure and Nomenclature

III. Biosynthetic Pathways and Carotenogenic Enzymes

IV. Genes Involved in Carotenoid Biosynthesis

V. Regulation of Carotenoid Biosynthesis

VI. Regulatory Genes

VII. Conclusions and Future Studies

References

Index