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Elsevier

Diabetes and Neurodegeneration

  • 1st Edition - December 3, 2025
  • Latest edition
  • Editors: Debasis Bagchi, Samudra Prosad Banik, Rameshwar Nath Chaurasia
  • Language: English

Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challe… Read more

Description

Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.

Key features

  • Identifies the cognitive impairment symptoms and the direct impact on the nervous system’s structure and electrophysiology
  • Explores disruptions in insulin signaling as key contributors to neurodegeneration in hyperglycemic individuals
  • Highlights early diagnostic and prognostic indicators of diabetes and cognitive impairment
  • Discusses signaling pathways including the insulin signaling pathway and the AGE-RAGE axis that connect diabetes and dementia
  • Evaluates the efficacy of antidiabetic drugs, targets insulin resistance, and critically assesses RAGE-based therapeutic interventions
  • Presents novel therapeutics to arrest and delink diabetes from the progression of cognitive impairment

Readership

Graduate students, researchers, clinical investigators, physicians and neurologists and professionals in the mental health field, neurotoxicologists, pharmacologists, and pharmacists

Table of contents

INTRODUCTION: PATHOGENESIS OF DIABETES AND DEMENTIA

1. Why and when does one have high blood sugar?

2. The History of hyperglycemia: key milestones in the inception of the disease in human health

3. Neurodegeneration: How to identify the primary symptoms of cognitive impairment

4. Direct consequences of diabetes over the nervous system: Structural and electrophysiological changes

DISCOVERING THE BRIDGE BETWEEN DIABETES AND DEMENTIA

5. Early Clinical Evidence that suggest a strong link between Hyperglycemia and onset of neurodegeneration

6. Case studies for a systematic understanding of development of dementia in diabetic or pre-diabetic patients

7. Susceptibility assessment of dementia in diabetic or prediabetic conditions

8. Metabolic connections between Diabetes and AD

9. Role of diabetes and altered metabolic homeostasis in age related dementia

10. Oxidative stress in brain accelerates the onset of neurodegeneration in hyperglycemic individuals

11. Cardiovascular diseases in diabetic individuals aggravate the propensity of dementia

12. Disruption of insulin signaling causes major cognitive impairment

BIOMARKERS AND PATHWAYS WHICH CONNECT DIABETES AND DEMENTIA

13. Early diagnostic and prognostic biomarkers of diabetes and cognitive impairment

14. Periphery biomarkers to assess the vulnerability of Type 2 diabetic patients to AD

15. Advanced Glycated End (AGE) Product: the most significant metabolic by-product implicated in dementia

16. The Physiological role of AGE: RAGE axis in the body: Implications in cellular defense

17. Role of AGE molecules in protein misfolding and aggregation

18. AGE molecules as major culprits behind amyloidogenic protein aggregation

19. Shared pathways of Type 2 diabetes and Alzheimer’s Disease

20. Role of gut microbial amyloids in progressive cognitive decline

21. Exploring the unknown territory of Gut: Brain axis in diabetic patients: impact of elevated blood sugar on microbial amyloids

THERAPEUTIC STRATEGIES TO ARREST AND/OR DELINK DIABETES AND DEMENTIA

22. Evaluation of efficacy of antidiabetic drugs to arrest dementia

23. Targeting Insulin resistance to treat cognitive impairment

24. RAGE based therapeutic interventions: Do they aggravate or ameliorate dementia?

25. Soluble form of RAGE (sRAGE) receptors as novel therapeutic intervention to arrest amyloid associated pathogenesis

26. Assessing the efficacy of antidiabetic phytotherapeutic interventions towards improvement of cognitive functions

FUTURE FRONTIERS IN DIABETES AND DEMENTIA

27. Commentary: Diabetes and cognitive health: How can we save the future generation

Product details

  • Edition: 1
  • Latest edition
  • Published: December 3, 2025
  • Language: English

About the editors

DB

Debasis Bagchi

Debasis Bagchi earned his Ph.D. in Medicinal Chemistry in 1982 and is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy. He also serves as Chief Scientific Officer at Cepham Research Center and holds adjunct faculty appointments. Previously, he was Senior Vice President of Research & Development at InterHealth Nutraceuticals (1998–2011) and later Director of Innovation and Clinical Affairs at Iovate Health Sciences (2011–2013).

Dr. Bagchi received the Master of the American College of Nutrition Award in 2010 and has held leadership roles including Past President of the American College of Nutrition and Past Chairman of the International Society of Nutraceuticals and Functional Foods. He contributes as an NIH peer reviewer and advisor to international health organizations.

A prolific scholar, he has authored over 320 peer-reviewed papers, 30 books, and holds 18 patents. He also serves on editorial boards of numerous scientific journals.

Affiliations and expertise
Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA

SB

Samudra Prosad Banik

Samudra Prosad Banik, Ph.D., received his PhD degree in Life Sciences from Jadavpur University in 2009 after working in the field of Fungal Biotechnology from the CSIR –Indian Institute of Chemical Biology, Kolkata, India. Dr. Banik is currently working as Assistant Professor at the Department of Microbiology, Maulana Azad College, University of Calcutta at Kolkata, India. After completing his Masters in Biophysics and Molecular Biology at the University of Kolkata in 2003, Dr. Banik was awarded a travel grant to work in a short project of genetically engineered rice with increased photosynthetic efficiency at International Rice Research Institute, Philippines. Thereafter he completed his PhD. at IICB where he identified an alternative pathway of vesicles mediated protein secretion in filamentous fungus, and performed biophysical characterization of the glycosylated fungal enzyme assemblies. Upon joining Maulana Azad College, Dr. Banik continued his research on behavior of glycosylated/glycated proteins in higher eukaryotes. In the process, he eventually shifted his attention towards glycated proteins formed during hyperglycemia and its associated consequences chiefly with regards to neuronal disorders. He has been the recipient of three research projects and has published more than 32 research articles in SCOPUS/Web of Science indexed journals along with 15 book chapters published by CRC Press/Wiley/CRC Press. Dr. Banik has edited one book on Biofuels which is scheduled to come out early next year from CRC Press/Taylor and Francis. He is an active reviewer of significant journals including Heliyon, PLOS One and Journal of American Nutrition Association. He is presently the Joint-Convenor of Research Committee at Maulana Azad College. His current research interests include understanding the mechanism of stabilization of proteins by osmolytes as well as structural changes inflicted in proteins due to glycation.

Affiliations and expertise
Department of Microbiology, Maulana Azad College, India

RC

Rameshwar Nath Chaurasia

Rameshwar Nath Chaurasia MBBS, MD, DM, MAMS received his D.M. in Neurology in 2009 from King George Medical University, Lucknow, India. He did his MBBS and M.D.(Medicine) from Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. At present he is Professor & Head in the Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi. He served in the University at various administrative posts like Student Advisor, Anti Ragging Committee of University team, Deputy Chief Proctor etc.,He also served as founder Nodal officer of Ayushman Bharat Yojana (Biggest Health Scheme Yojana in World) in Sir Sundar Lal Hospital, I.M.S. BHU. He is Executive Council Member of AIIMS, Gorakhpur, Uttar Pradesh, India. Dr. Chaurasia received various awards/prizes from different Scientific/Non-scientific organizations and Societies for creating awareness about various neurological diseases in societies. His passion is to serve the needy people of India living in remote areas of different states of India by arranging health camps with the help of National Medicos Organization and Sewa Bharati of India. He also got teacher awards on teacher’s day from Governor and Chief Minister of Uttar Pradesh, India in 2017 and 2021 respectively. Dr R N Chaurasia has contributed >90 research papers in various peer reviewed national and international journals. He also contributed >10 book chapters in various books. He is reviewer of many national and international peer reviewed journals (>6). His main area of research is in the field of stroke, Epilepsy, cognitive science and CNS infections. He is member of various academic bodies in the field of neurosciences like Indian Academy of Neurology, Neurological Society of India, International Parkinson and Movement Disorder Society & American Academy of Neurology etc.
Affiliations and expertise
Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

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