Diagnostic Pathology: Infectious Diseases

3rd Edition - December 28, 2023
Latest edition
Authors: Isaac H. Solomon, Dan Milner
Language: English

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of in… Read more

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Description

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of infectious diseases, including novel infections and lesser-known microorganisms, this volume incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Infectious Diseases is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.

Key features

Covers all areas of infectious disease pathology, including infections of the central nervous system, head and neck, and skin/soft tissue as well as the pulmonary, cardiac, gastrointestinal, genitourinary, and gynecologic systems
Includes new chapters on COVID-19 and mpox, nine new helminth chapters, additional new fungal chapters, an updated biosafety chapter, and more
Contains significantly updated information throughout, including new content on artificial intelligence, whole-slide and mass spectrometry imaging, and metagenomic next-generation sequencing
Discusses the best approach for diagnostic work-up and addresses the challenges in maximizing diagnostic yield while avoiding misinterpretation of results that could lead to false positives
Details the increasing use of molecular diagnostics in infectious disease pathology
Provides updates on taxonomy and nomenclature across all classes of infectious microorganisms (bacteria, fungi, parasites, viruses) along with new genomic data
Features more than 1,500 print and online-only images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis
Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care
Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Readership

Infectious disease pathologists, surgical pathologists

SECTION 1: OVERVIEW

4 Standard Methods for Infectious Diseases
Zoe Freeman Weiss, MD, Nicole Pecora, MD, PhD, and Shira Winters, MD

10 Emerging Techniques
Jessica Crothers, MD

12 Biosafety Considerations
Jessica Crothers, MD

16 Pitfalls and Artifacts
Jessica Crothers, MD, Alvaro C. Laga, MD, MMSc, and Isaac H. Solomon, MD, PhD

SECTION 2: VIRAL INFECTIONS
DNA VIRUSES

22 Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections
Isaac H. Solomon, MD, PhD, Leigh Compton, MD, and Dan Milner, MD, MSc(Epi), MBA

28 Varicella-Zoster Virus (HHV-3) Infections
Isaac H. Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

32 Epstein-Barr Virus (HHV-4) Infection
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

38 Cytomegalovirus (HHV-5) Infections
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

44 Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections
Isaac H. Solomon, MD, PhD

46 Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection
Isaac H. Solomon, MD, PhD, Leigh Compton, MD, and Dan Milner, MD, MSc(Epi), MBA

52 Herpes B Virus Infection
Isaac H. Solomon, MD, PhD

54 Adenovirus Infection
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

58 Hepatitis B and D Virus Infections
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

62 Parvovirus B19 Infection
Isaac H. Solomon, MD, PhD, Leigh Compton, MD, and Dan Milner, MD, MSc(Epi), MBA

66 JC Virus, BK Virus, and Other Polyomavirus Infections
Isaac H. Solomon, MD, PhD

72 Human Papillomavirus Infection
Isaac H. Solomon, MD, PhD, T. Rinda Soong, MD, PhD, MPH, and Dan Milner, MD, MSc(Epi), MBA

78 Molluscum Contagiosum
Isaac H. Solomon, MD, PhD

80 Smallpox, Mpox, and Other Pox Virus Infections
Alvaro C. Laga, MD, MMSc, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

RNA VIRUSES

86 Arbovirus Infections
Isaac H. Solomon, MD, PhD

92 Zika Virus Infection
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

96 Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

102 Enterovirus Infections
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi),MBA

104 Poliovirus Infection
Jessica Crothers, MD and Isaac H. Solomon, MD, PhD

106 Rabies Virus Infection
Isaac H. Solomon, MD, PhD

108 Lymphocytic Choriomeningitis Virus Infection
Isaac H. Solomon, MD, PhD

110 Measles Virus Infection
Isaac H. Solomon, MD, PhD

112 Mumps Virus Infection
Isaac H. Solomon, MD, PhD

114 Rubella Virus Infection
Isaac H. Solomon, MD, PhD

116 Human Immunodeficiency Virus Infection
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

120 Human T-Lymphotropic Virus Type I Infection
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

122 Influenza Virus Infections
Isaac H. Solomon, MD, PhD

126 Parainfluenza Virus Infections
Isaac H. Solomon, MD, PhD

128 Coronavirus Disease 2019 (COVID-19)
Isaac H. Solomon, MD, PhD

134 Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections
Isaac H. Solomon, MD, PhD

136 Respiratory Syncytial Virus Infection
Isaac H. Solomon, MD, PhD and Eleanor Russell-Goldman,MD, PhD

138 Rhinoviruses, Human Metapneumovirus, and Other Respiratory Virus Infections
Isaac H. Solomon, MD, PhD

140 Rotavirus, Norovirus, and Astrovirus Infections
Isaac H. Solomon, MD, PhD

142 Hepatitis A and E Virus Infections
Isaac H. Solomon, MD, PhD

146 Hepatitis C Virus Infection
Isaac H. Solomon, MD, PhD, Eleanor Russell-Goldman, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

SECTION 3: PRION DISEASES

152 Transmissible Spongiform Encephalopathies
Isaac H. Solomon, MD, PhD

SECTION 4: BACTERIAL INFECTIONS

158 Bacterial Classification and Diagnosis
Nicole Pecora, MD, PhD

160 Botryomycosis
Isaac H. Solomon, MD, PhD and Malak Abedalthagafi, MD, MBA

162 Malakoplakia
Malak Abedalthagafi, MD, MBA and Leigh Compton, MD

GRAM-POSITIVE BACTERIA

164 Actinomycosis
Isaac H. Solomon, MD, PhD, Nicole Pecora, MD, PhD, and Leigh Compton, MD

166 Bacillus Species Infections
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

170 Clostridioides and Other Gram-Positive Anaerobes
Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD

174 Corynebacterium Species Infections
Nicole Pecora, MD, PhD

178 Listeria Species Infection
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

180 Rhodococcus Species Infection
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

182 Staphylococcus Species Infections
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

188 Streptococcus and Enterococcus Species Infections
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

192 Whipple Disease
Jessica Crothers, MD, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

GRAM-NEGATIVE BACTERIA

196 Pathologically Important Enterobacterales: Escherichia, Shigella, Salmonella, Klebsiella, and Yersinia Species Infections
Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD

204 Fastidious Organisms: Brucella, Francisella, Haemophilus, and Legionella Species Infections
Nicole Pecora, MD, PhD

210 Nonfermentative Organisms: Acinetobacter, Burkholderia, and Pseudomonas Species Infections
Zoe Freeman Weiss, MD, Nicole Pecora, MD, PhD, and Lenette Lu, MD, PhD

216 Bacteroides, Fusobacterium, and Other Gram- Negative Anaerobes
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

220 Bartonella Species Infections
Isaac H. Solomon, MD, PhD and Alvaro C. Laga, MD, MMSc

222 Campylobacter and Vibrio Species Infections
Zoe Freeman Weiss, MD and Nicole Pecora, MD, PhD

226 Helicobacteriosis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

228 Neisseria and Moraxella Species Infections
Nicole Pecora, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

232 Pertussis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

234 Intestinal Spirochetosis
Isaac H. Solomon, MD, PhD, Leigh Compton, MD, and Nicole Pecora, MD, PhD

236 Borrelia Species Infections
Isaac H. Solomon, MD, PhD and Nicole Pecora, MD, PhD

240 Leptospira Species Infection
Isaac H. Solomon, MD, PhD and Nicole Pecora, MD, PhD

242 Syphilis and Other Treponematoses
Alvaro C. Laga, MD, MMSc, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

248 Anaplasmosis and Ehrlichiosis
Isaac H. Solomon, MD, PhD, Nicole Pecora, MD, PhD, andLenette Lu, MD, PhD

252 Chlamydophila and Chlamydia Species Infections
Nicole Pecora, MD, PhD

256 Coxiella Species Infection
Isaac H. Solomon, MD, PhD and Nicole Pecora, MD, PhD

258 Rickettsia and Orientia Species Infections
Isaac H. Solomon, MD, PhD and Nicole Pecora, MD, PhD

262 Mycoplasma and Ureaplasma Species Infections
Zoe Freeman Weiss, MD and Isaac H. Solomon, MD, PhD

ACID-FAST BACTERIA

264 Mycobacterium tuberculosis Complex Infections
Nicole Pecora, MD, PhD, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

270 Leprosy
Malak Abedalthagafi, MD, MBA, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

274 Buruli Ulcer
Alvaro C. Laga, MD, MMSc

276 Mycobacterium avium Complex and Other Nontuberculous Mycobacterial Infections
Nicole Pecora, MD, PhD and Zoe Freeman Weiss, MD

280 Nocardiosis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

SECTION 5: FUNGAL INFECTIONS

286 Fungal Classification and Diagnosis
Alvaro C. Laga, MD, MMSc and Dan Milner, MD, MSc(Epi), MBA

MOLDS

290 Aspergillosis
Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Isaac H. Solomon, MD, PhD

296 Entomophthoramycosis
Alvaro C. Laga, MD, MMSc

300 Fusariosis
Alvaro C. Laga, MD, MMSc, Zoe Freeman Weiss, MD, and Nicole Pecora, MD, PhD

302 Mucormycosis
Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Isaac H. Solomon, MD, PhD

306 Mycetoma
Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Brian J. Hall, MD

310 Phaeohyphomycosis
Alvaro C. Laga, MD, MMSc, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

312 Scedosporiosis and Lomentosporiosis
Alvaro C. Laga, MD, MMSc, Zoe Freeman Weiss, MD, and Eleanor Russell-Goldman, MD, PhD

314 Scopulariopsis Infections
Zoe Freeman Weiss, MD, Alvaro C. Laga, MD, MMSc, and Eleanor Russell-Goldman, MD, PhD

316 Tineasis
Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Isaac H. Solomon, MD, PhD

318 Trichosporonosis
Isaac H. Solomon, MD, PhD, Alvaro C. Laga, MD, MMSc, and Dan Milner, MD, MSc(Epi), MBA

320 Superficial Mycoses
Alvaro C. Laga, MD, MMSc

YEASTS AND YEAST-LIKE ORGANISMS

324 Blastomycosis
Jessica Crothers, MD

330 Candidiasis
Jessica Crothers, MD, T. Rinda Soong, MD, PhD, MPH, and Isaac H. Solomon, MD, PhD

336 Chromoblastomycosis
Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD

340 Coccidioidomycosis
Malak Abedalthagafi, MD, MBA and Isaac H. Solomon, MD, PhD

344 Cryptococcosis
Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Isaac H. Solomon, MD, PhD

350 Histoplasmosis
Alvaro C. Laga, MD, MMSc, T. Rinda Soong, MD, PhD, MPH, and Nicole Pecora, MD, PhD

356 Lobomycosis
Alvaro C. Laga, MD, MMSc

358 Paracoccidioidomycosis
Isaac H. Solomon, MD, PhD and Eleanor Russell-Goldman, MD, PhD

360 Pneumocystosis
Jessica Crothers, MD, Eleanor Russell-Goldman, MD, PhD, and Isaac H. Solomon, MD, PhD

364 Sporotrichosis
Alvaro C. Laga, MD, MMSc, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

368 Talaromycosis
Alvaro C. Laga, MD, MMSc, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

370 Rhinosporidiosis
Alvaro C. Laga, MD, MMSc

372 Protothecosis
Jessica Crothers, MD

SECTION 6: PROTOZOAN PARASITIC INFECTIONS

376 Parasite Classification and Diagnosis
Alvaro C. Laga, MD, MMSc, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

GASTROINTESTINAL AND OTHER LUMINAL PROTOZOA

380 Balantidiasis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

382 Cryptosporidiosis and Other Coccidia Infections
Isaac H. Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan Milner, MD, MSc(Epi), MBA

386 Entamebiasis
Malak Abedalthagafi, MD, MBA and Isaac H. Solomon, MD, PhD

390 Giardiasis
Malak Abedalthagafi, MD, MBA, Eleanor Russell-Goldman, MD, PhD, and Isaac H. Solomon, MD, PhD

392 Microsporidiosis
Isaac H. Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan Milner, MD, MSc(Epi), MBA

394 Trichomoniasis
Isaac H. Solomon, MD, PhD and T. Rinda Soong, MD, PhD, MPH

INTRAVASCULAR PROTOZOA

396 African Trypanosomiasis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

398 Babesiosis
Malak Abedalthagafi, MD, MBA, Dan Milner, MD, MSc(Epi), MBA, and Lenette Lu, MD, PhD

402 Malaria
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

DEEP TISSUE PROTOZOA

408 Free-Living Amebiasis
Alvaro C. Laga, MD, MMSc, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

414 American Trypanosomiasis
Isaac H. Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Eleanor Russell-Goldman, MD, PhD

416 Leishmaniasis
Malak Abedalthagafi, MD, MBA, Dan Milner, MD, MSc(Epi), MBA, and Isaac H. Solomon, MD, PhD

420 Toxoplasmosis
Isaac H. Solomon, MD, PhD, Malak Abedalthagafi, MD, MBA, and Dan Milner, MD, MSc(Epi), MBA

SECTION 7: HELMINTHIC PARASITIC INFECTIONS
NEMATODES

426 Ancylostomiasis and Necatoriasis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

428 Angiostrongyliasis
Isaac H. Solomon, MD, PhD

430 Ascariasis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

434 Enterobiasis
Jessica Crothers, MD and Isaac H. Solomon, MD, PhD

438 Gnathostomiasis
Alvaro C. Laga, MD, MMSc

440 Human Filariasis
Malak Abedalthagafi, MD, MBA, Isaac H. Solomon, MD, PhD, and Eleanor Russell-Goldman, MD, PhD

444 Onchocerciasis
Malak Abedalthagafi, MD, MBA

446 Strongyloidiasis
Malak Abedalthagafi, MD, MBA and Isaac H. Solomon, MD, PhD

450 Trichuriasis
Isaac H. Solomon, MD, PhD and Dan Milner, MD, MSc(Epi), MBA

454 Trichinellosis
Jessica Crothers, MD

TREMATODES

456 Clonorchiasis and Opisthorchiasis
Jessica Crothers, MD

460 Fascioliasis and Fasciolopsiasis
Jessica Crothers, MD

462 Paragonimiasis
Jessica Crothers, MD

464 Schistosomiasis
Dan Milner, MD, MSc(Epi), MBA and Isaac H. Solomon, MD, PhD

CESTODES

470 Coenurosis
Isaac H. Solomon, MD, PhD

472 Cysticercosis
Isaac H. Solomon, MD, PhD

478 Diphyllobothriasis and Hymenolepiasis
Jessica Crothers, MD

482 Echinococcosis
Dan Milner, MD, MSc(Epi), MBA and Isaac H. Solomon, MD, PhD

486 Sparganosis
Isaac H. Solomon, MD, PhD

SECTION 8: INFESTATIONS AND OTHER INVERTEBRATE-RELATED MALADIES

490 Tissue Damage From Arachnids and Insects
Alvaro C. Laga, MD, MMSc, Isaac H. Solomon, MD, PhD, and Dan Milner, MD, MSc(Epi), MBA

498 Myiasis
Malak Abedalthagafi, MD, MBA and Dan Milner, MD, MSc(Epi), MBA

500 Scabies
Malak Abedalthagafi, MD, MBA, Leigh Compton, MD, and Dan Milner, MD, MSc(Epi), MBA

502 Demodex Infestations
Malak Abedalthagafi, MD, MBA and Dan Milner, MD, MSc(Epi), MBA

504 Tungiasis
Malak Abedalthagafi, MD, MBA and Dan Milner, MD, MSc(Epi), MBA

Product details

Edition: 3
Latest edition
Published: December 28, 2023
Language: English

About the authors

Isaac H. Solomon

Isaac H. Solomon, MD, PhD, is an Associate Pathologist in the Department of Pathology at Brigham and Women’s Hospital and an Assistant Professor of Pathology at Harvard Medical School in Boston, Massachusetts. Solomon retains the status of Neurooncology Member at the Dana Farber/Harvard Cancer Center in Boston, Massachusetts.

Affiliations and expertise

Associate Pathologist, Department of Pathology, Brigham and Women’s Hospital, Assistant Professor of Pathology, Harvard Medical School, Boston, Massachusetts, USA

Dan Milner

Dan Milner, MD, MSc(Epi), MBA, is a consultant pathologist, executive director, and medical director at Libragem Consulting, LLC, in Palm Springs, California, and an Associate Professor at the Department of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health in Boston, Massachusetts

Affiliations and expertise

Consultant Pathologist, Executive Director, & Medical Director, Libragem Consulting, LLC, Palm Springs, California, Associate Professor, Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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