Drug Design

List of Contributors

Preface

Contents of Other Volumes

Chapter 1. Diphenhydramine Derivatives: Through Manipulation toward Design

I. Introduction. The Benzhydryl Moiety in Drugs

II. Review of the Synthetic Routes to Structures of the Diphenhydramine Type

III. The Phase of Manipulation. Classical Approaches to Arrive at Active Structures of the Diphenhydramine Type

IV. Detailed Analysis of the Conditions for Activity in Structures of the Diphenhydramine Type as a Basis for Rational Design

V. Metabolism of Diphenhydramines in Relation to Design

VI. Concluding Remarks

References

Chapter 2. The Design of Antiradiation Agents

I. Introduction

II. The Nature of Radiation Damage

III. Evaluation of Potential Antiradiation Agents

IV. Theories of Protection

V. Chemical Radioprotective Agents

VI. Other Applications of Antiradiation Drugs

VII. The Future

References

Chapter 3. Rational Approach to Proteinase Inhibitors

I. Introduction

II. Lysine Homologs as Proteinase Inhibitors

III. Arginine Homologs as Proteinase Inhibitors

IV. Peptides as Proteinase Inhibitors

V. Coding, Decoding, and Noise in Proteolytic Reactions

References

Chapter 4. The Design of Organ-Imaging Radiopharmaceuticals

I. Introduction

II. Essential Properties

HI. Design Concepts

IV. Imaging Agents—Current Status

References

Chapter 5. Design of X-Ray Contrast Media

I. The Uses of Radiographic Contrast Agents

II. Physical Basics

III. Chemistry of Contrast Agents

IV. Physicochemical Properties of Contrast Agents

V. Toxicology

VI. Pharmacology and Pharmacokinetics

VII. The Risks of X-Ray Contrast Diagnosis

VIII. New Drug Design

References

Chapter 6. Agricultural Pesticides: Chemical and Physical Methods of Formulation

I. Introduction

II. Pesticides in the Immediate Environment

III. Systemic Pesticides in Agriculture

IV. Physical Formulation

V. Chemical Formulation

References

Subject Index