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Elsevier

Electrocardiography of Laboratory Animals

Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countr… Read more

Description

Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research.

Key features

  • Covers safety electrocardiography of large laboratory animals
  • Offers comprehensive analysis of ECGs for practical laboratory use
  • Includes a self-evaluation section for testing of ECG reading and analysis

Readership

Primary Audience: Researchers working with primates, dogs and mini-pigs in academia, pharma, or contract research organization across the biological and medical sciences. Secondary Audience: Vets working with primates, dogs and mini-pigs; Zoologists working with primates, dogs and mini-pigs; and Veterinary professors and students teaching/taking cardiology and ECG course for accreditation

Table of contents

Dedication

Preface

Foreword

Acknowledgements

Chapter 1. Electrocardiography in Preclinical Safety

Introduction

Regulatory Guidance versus Good Science versus Rationale Drug Development

Safety Pharmacology versus Toxicology

Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity

Cardiotoxicity Endpoints in Toxicology

The ECG and Drug Safety

Chapter 2. Principles of Electrocardiography

Recording the ECG

Cardiac Conduction and Waveform Genesis

Evaluation of the Electrocardiogram

Transmembrane Action Potentials

Evaluation of Waveforms

Mean Electrical Axis

Equipment Considerations

Cardiac Effects of Systemic Potassium and Calcium Abnormalities

Chapter 3. Canine Electrocardiography

Introduction

Etiology, Pathophysiology, and Gross Pathology

Rhythm Diagnosis

Chapter 4. Handling and Restraint of Nonhuman Primates

Cynomolgus and Rhesus

Machine Setup and Configuration

Lead Placement

Obtaining the Tracing

Chemical Restraint

Tracing Handling and Storage

Chapter 5. Electrocardiography of Nonhuman Primates

Fundamental Principles of Electrocardiography

Electrocardiography of Cynomolgus and Rhesus Monkeys

Cardiac Arrhythmias

Chimpanzee Electrocardiography

Chapter 6. Electrocardiography of Minipigs

Normal Values

Normal Variants in Order of Occurrence (Commonality)

Lead Placement

Fundamental Principles of Electrocardiography

Electrocardiography of Minipigs (Sus scrofa)

Cardiac Arrhythmias

Sinoatrial Arrhythmias

Supraventricular Arrhythmias

Ventricular Arrhythmias

Abnormalities of Impulse Conduction

Miscellaneous Disturbances

Normal Variants

Chapter 7. Telemetry in Preclinical Safety Studies

Chapter 8. PR (PQ), QRS, QT, and Other Issues

The PR (PQ) Interval

QRS Complex Duration

QT Interval Duration

Chapter 9. Self-Test

Canine ECG Examples

Answers

References

Index

Review quotes

"…this book might be beneficial to ECG neophytes, veterinary and laboratory technicians who are involved in performing ECGs, and veterinary and graduate students."—Journal of the American Veterinary Medical Association, 15-Sep-14

"There are a number of normal variants in the electrocardiograms of common laboratory animals, say Richig and Sleeper, and if researchers know what is normal for the particular species they are working with, they can avoid excluding those individuals which are within these normal variant ranges."—ProtoView.com, April 2014

Product details

About the authors

JR

Jeffrey W. Richig

Jeffrey W. Richig, DVM is CEO of ECGVET, LLC and Special Government Employee consultant to the FDA for the cardiovascular and renal drugs division. He has over twenty-five years of experience in electrocardiography for pre-clinical safety evaluation studies and is known as a leading expert in the field.
Affiliations and expertise
CEO of ECGVET, LLC and Special Government Employee consultant to the FDA's cardiovascular and renal drugs division, USA

MS

Meg M. Sleeper

Meg Sleeper, VMD, graduated cum laude from the University of Pennsylvania veterinary school in 1993. She is an associate professor of cardiology and served as section chief from 2001 to 2011. Dr. Sleeper has published over 70 peer-reviewed original papers, more than 50 review papers or case reports, and authored 4 books. She has lectured at numerous prestigious conferences, including the American Heart Association and the American College of Veterinary Internal Medicine Forum, and has coordinated the small animal cardiology section at the AVMA conference since 2009. Dr. Sleeper has trained 18 veterinary cardiologists and joined the University of Florida veterinary school faculty in 2015. She serves on the editorial or review boards of 11 journals and has contributed to the Great Ape Heart Project since 2011, focusing on improving cardiac health in ape species.

Affiliations and expertise
Clinical Professor, Cardiology, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Florida, Gainsville, FL, USA

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