Endothelium and Cardiovascular Diseases
Vascular Biology and Clinical Syndromes
- 2nd Edition - November 25, 2025
- Latest edition
- Editors: Protasio L. Da Luz, Peter Libby, Antonio Carlos Palandri Chagas, Francisco Rafael Martins Laurindo
- Language: English
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes, Second Edition offers new discoveries in clinical settings, cellular, molecular, genetic,… Read more
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Description
Description
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes, Second Edition offers new discoveries in clinical settings, cellular, molecular, genetic, and epigenetic mechanisms which have led to novel understanding of the key role of endothelium in both cardiovascular and non-cardiovascular diseases. The innovations it presents have implications for both pathophysiological concepts and clinical decisions. Among other topics, cardiovascular and pulmonary medicine, immunity and inflammation, genetics and epigenetics, heart failure, renal disease, familial hypercholesterolemia, diabetes, and hypertension are discussed at length.
With 20 new chapters covering everything from endothelium transition to connective tissue disorders, this second edition is sure to be indispensable to anyone wishing to learn the importance of endothelium to every facet of health.
Key features
Key features
- Examines the ways in which endothelium relates to almost every cardiovascular and systemic disease
- Provides a critical, in depth, pathophysiological review of endothelium which cannot be found in any other single volume
- Offers cutting-edge, critical knowledge for investigators and practitioners alike, information which has evolved rapidly since the previous edition
Readership
Readership
Postgraduate and graduate medical students, researchers in CVD, clinical practitioners
Table of contents
Table of contents
1. Signal Transduction Pathways in Endothelial Cells: Implications for Angiogenesis
2. Endothelial Barrier: Factors That Regulate Its Permeability
3. Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis
4. Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators
5. Vasoconstrictor Substances Produced by the Endothelium
6. Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease
7. Endothelium and Immune System
8. Progenitor Cells - Origins and Endothelium Regeneration
9. Blood Coagulation and Endothelium
10. Platelets and Endothelium
11. Endothelium and Genetics
12. Regulation of Endothelial Function: With Focus RNAs, MicroRNAs, and LncRNAs
13. Endothelium and Renin-Angiotensin System
14. Methods to Investigate Endothelial Function in Humans
15. Endothelium to Mesenchymal Transition - Contributions to Vascular Diseases
16. Endothelial Products as Plasmatic Biomarker of Vascular Dysfunction
17. Endothelial Alterations in Aging
18. Vascular Function and Cognitive Decline
19. Emotional Stress and Influences on Endothelium
20. Cardiac Arrhythmias and Endothelium
21. Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction
22. Non-HDL Particles, Triglycerides and Endothelium - NEW CHAPTER
23. Risk Factors for Endothelial Dysfunction and Early Onset of Cardiovascular Diseases in the Young
24. Endothelial Dysfunction and Myocardial Injury in COVID-19
25. Colchicine for the Prevention of Cardiovascular Disease
26. Venous Thromboembolism and Endothelium
27. Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis
28. Influences of Diet on Endothelial Dysfunction
29. Endothelium and Microbiota as Regulators of Metabolic Process
30. Effects of Red Wine and Polyphenols on Endothelial Function and Clinical Events
31. Kidney and the Endothelium
32. Endothelial Alterations in Pulmonary Hypertension
33. Endothelial Alterations in Chronic Coronary Disease
34. Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes
35. Integrating Multiomic Approaches to Uncover Candidate Gene Networks for Endothelial Dysfunction in Response do CVD Risk Factors
36. Endothelium - Coordinator of Acute and Chronic Inflammation
37. Endothelium in Atherosclerosis: Plaque Formation and Its Complications
38. Endothelial Function and Cardiovascular Risk Factors Interactions
39. Sleep Disorders and Endothelial Dysfunction
40. Smoking and the Endothelium
41. Effects of radiation upon Vascular Endothelium
42. Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women with Angina and Non-obstructive Coronaries
43. Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis
44. Endothelium Function in HF with Preserved EF
45. Endothelium in Cardiomyopathies
46. Post percutaneous Interventions: Endothelial Repair
47. Stents and the Endothelium
48. Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options
49. Erectile Dysfunction and the Endothelium
50. Cardiovascular Actions and Therapeutic Implications of Endothelium-Derived Catecholamines
51. Obesity, Endothelium and Metabolic Syndrome
52. Endothelium in Diabetes
53. Endothelial Mechanisms in Preeclampsia
54. Angiogenesis and Tumor Vasculature Function
55. Corneal Endothelium Cell Dysfunction
56. Connective Tissue and Endothelium
57. Physical Exercise and the Endothelium
58. The Translational Concept in Endothelium - From Research to Clinical Practice
59. Advancements in Understanding the Interplay between Endothelial Dysfunction and Arterial Hypertension
2. Endothelial Barrier: Factors That Regulate Its Permeability
3. Hemodynamic Forces in the Endothelium: From Mechanotransduction to Implications on Development of Atherosclerosis
4. Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators
5. Vasoconstrictor Substances Produced by the Endothelium
6. Redox Cellular Signaling Pathways in Endothelial Dysfunction and Vascular Disease
7. Endothelium and Immune System
8. Progenitor Cells - Origins and Endothelium Regeneration
9. Blood Coagulation and Endothelium
10. Platelets and Endothelium
11. Endothelium and Genetics
12. Regulation of Endothelial Function: With Focus RNAs, MicroRNAs, and LncRNAs
13. Endothelium and Renin-Angiotensin System
14. Methods to Investigate Endothelial Function in Humans
15. Endothelium to Mesenchymal Transition - Contributions to Vascular Diseases
16. Endothelial Products as Plasmatic Biomarker of Vascular Dysfunction
17. Endothelial Alterations in Aging
18. Vascular Function and Cognitive Decline
19. Emotional Stress and Influences on Endothelium
20. Cardiac Arrhythmias and Endothelium
21. Lipids and Lipoprotein Mediators of Endothelial Function and Dysfunction
22. Non-HDL Particles, Triglycerides and Endothelium - NEW CHAPTER
23. Risk Factors for Endothelial Dysfunction and Early Onset of Cardiovascular Diseases in the Young
24. Endothelial Dysfunction and Myocardial Injury in COVID-19
25. Colchicine for the Prevention of Cardiovascular Disease
26. Venous Thromboembolism and Endothelium
27. Artificial Lipoproteins in Endothelial Dysfunction and Atherosclerosis
28. Influences of Diet on Endothelial Dysfunction
29. Endothelium and Microbiota as Regulators of Metabolic Process
30. Effects of Red Wine and Polyphenols on Endothelial Function and Clinical Events
31. Kidney and the Endothelium
32. Endothelial Alterations in Pulmonary Hypertension
33. Endothelial Alterations in Chronic Coronary Disease
34. Molecular Mechanisms of the Arterial Wall in Acute Coronary Syndromes
35. Integrating Multiomic Approaches to Uncover Candidate Gene Networks for Endothelial Dysfunction in Response do CVD Risk Factors
36. Endothelium - Coordinator of Acute and Chronic Inflammation
37. Endothelium in Atherosclerosis: Plaque Formation and Its Complications
38. Endothelial Function and Cardiovascular Risk Factors Interactions
39. Sleep Disorders and Endothelial Dysfunction
40. Smoking and the Endothelium
41. Effects of radiation upon Vascular Endothelium
42. Endothelial Dysfunction and Coronary Microvascular Dysfunction in Women with Angina and Non-obstructive Coronaries
43. Endothelial Alterations in Heart Failure—Mechanisms and Molecular Basis
44. Endothelium Function in HF with Preserved EF
45. Endothelium in Cardiomyopathies
46. Post percutaneous Interventions: Endothelial Repair
47. Stents and the Endothelium
48. Vascular Disease of the Transplanted Heart: Physiopathology and Therapeutic Options
49. Erectile Dysfunction and the Endothelium
50. Cardiovascular Actions and Therapeutic Implications of Endothelium-Derived Catecholamines
51. Obesity, Endothelium and Metabolic Syndrome
52. Endothelium in Diabetes
53. Endothelial Mechanisms in Preeclampsia
54. Angiogenesis and Tumor Vasculature Function
55. Corneal Endothelium Cell Dysfunction
56. Connective Tissue and Endothelium
57. Physical Exercise and the Endothelium
58. The Translational Concept in Endothelium - From Research to Clinical Practice
59. Advancements in Understanding the Interplay between Endothelial Dysfunction and Arterial Hypertension
Product details
Product details
- Edition: 2
- Latest edition
- Published: November 25, 2025
- Language: English
About the editors
About the editors
PD
Protasio L. Da Luz
Professor Protásio L. da Luz, MD, FACC received his medical degree and completed a Residency and Specialization in Cardiology at Universidade de São Paulo Brazil (USP), and completed a postgraduate Fellowship in Critical Care Medicine at the University of Southern California. He has been a Research Scientist at Cedars-Sinai Medical Center, Full Professor of Cardiology at the Heart Institute (InCor) School of Medicine, USP, and Director of the InCor’s Cardiology Division and Atherosclerosis Unit. He is a Full Member of the Brazilian Academy of Sciences, Academy of Sciences of the State of São Paulo, and has authored or co-authored over 490 scientific publications and book chapters (258 of them peer-reviewed). Primary research interests include endothelium, atherosclerosis, coronary artery disease and prevention, and translational medicine. He received the Brazilian National Award for Scientific Merit, the Order of Medical Merit from the Brazilian government, and the Fundação Conrado Wessel Award in Medicine.
Affiliations and expertise
Research Scientist at Cedars-Sinai Medical Center, Brazil
Professor, Cardiology at the Heart Institute (InCor) School of Medicine, University of São Paulo, São Paulo, Brazil
Director, InCor’s Cardiology Division and Atherosclerosis Unit, BrazilPL
Peter Libby
Dr. Peter Libby is a cardiovascular medicine specialist at Brigham and Women’s Hospital and Mallinckrodt Professor of Medicine at Harvard Medical School (HMS). Receiving his medical degree from the University of California, San Diego School of Medicine, he undertook a cellular physiology research fellowship at HMS. After a residency in internal medicine and a fellowship in cardiovascular disease, he became board certified in both. He is an editor of the leading cardiovascular medicine textbook, and the author of over 500 peer-reviewed publications, 575 reviews, chapters, etc. He has received funding from the American Heart Association (AHA) and National Institutes of Health, plus recognitions on four continents, including the AHA and American College of Cardiology’s highest research awards, the Gold Medal of the European Society of Cardiology, the Anitschkow award from the European Atherosclerosis Society, the Ernst Jung Gold Medal for Medicine, and the Earl Benditt award for vascular biology.
Affiliations and expertise
Brigham and Women’s Hospital, Harvard Medical School, USAAP
Antonio Carlos Palandri Chagas
Antonio Carlos Palandri Chagas MD, PhD, is Professor of Medicine and Chief of Cardiology at the Medical School of ABC, São Paulo Brazil, where he earned his medical degree. His Residency in Internal Medicine and postgraduate work in cardiology were at the University of São Paulo; his PhD thesis covered myocardial ischemia. His postdoctoral fellowship was at the University of California San Francisco’s Cardiovascular Research Institute. A Fellow of the American College of Cardiology (ACC) who serves on the board of the JACC, he was the Brazilian Chapter’s first governor. He belongs to the European Society of Cardiology. He was president of the São Paulo State Society of Cardiology, and the Brazilian Society of Cardiology. He attained ACC’s International Service Award; Chief of the Department of Internal Medicine at the Medical School of ABC; and Chair of ACC’s International Assembly of Governors. He has authored over 145 peer-reviewed journal publications.
Affiliations and expertise
Professor of Medicine and Chief of Cardiology at the Medical School of ABC, São Paulo, BrazilFM
Francisco Rafael Martins Laurindo
Professor Francisco Rafael Martins Laurindo, MD received his medical degree and completed his Internal Medicine and Cardiology residency at the Heart Institute at the University of São Paulo School of Medicine in Brazil (FMUSP), where he earned his PhD on signaling processes in the vascular system. He trained in Physiology and Pharmacology at the University of Health Sciences, Bethesda, Maryland. He founded and has directed the Vascular Biology Laboratory at the Heart Institute (InCor), FMUSP since 2008. He is author or co-author of over 145 publications in peer-reviewed journals. He is a member of the Board of Directors of the Brazilian Academy of Sciences and a past Council Member of the Society for Free Radical Biology. He belongs to the Editorial Boards of Free Radical Biology and Medicine and Clinical Science, and served as Chair and Vice-Chair of the Gordon Research Conference on Nox Family NADPH Oxidases.
Affiliations and expertise
Professor, Faculty of Medicine, University of São Paulo, São Paulo, BrazilView book on ScienceDirect
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