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Elsevier

Environmental Epigenetics in Toxicology and Public Health

  • 1st Edition, Volume 22 - October 18, 2020
  • Latest edition
  • Editors: Rebecca Fry, Trygve O. Tollefsbol
  • Language: English

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic component… Read more

Description

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects.

This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures.

Key features

  • Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance
  • Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification
  • Features contributions from international experts in the field

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, molecular biology, toxicology, public health, environmental science; life science researchers; oncologists; immunologists; bioengineers; developmental biologists

Table of contents

Section I. Epigenetic Mechanisms/Machinery

1. DNA methylation/chromatic regulation/non-coding RNAs

2. Tools for the assessment of epigenetic regulation

Section II. Transdisciplinary approaches for the study of environmental epigenetics

3. Model organisms and their application in environmental epigenetics

4. Epidemiological concepts in environmental epigenetics

Section III. Epigenetic programming of disease in relation to the environment

5. Pregnancy and Birth outcomes

6. Neurodevelopment outcomes

7. Cancer

8. Respiratory dysfunction

9. Immune dysfunction

10. Cardio/Metabolic disease

11. Aging

Section IV. Transgenerational epigenetic effects of the environment

12. Transgenerational effects of environmental contaminants

Section V. Epigenome-targeted therapies in environmental health science

13. Nutrition

14. Manipulation of Epigenetic machinery

Section VI. Conclusions and Future Perspectives

15. Conclusions and Future Perspectives: The environment and the epigenome

Review quotes

"This is an important entry in the Translational Epigenetic series at a time that such methods are moving from a status of novel to practice and even translational. This beautifully illustrated volume in the series will likely become useful, if not essential, for two groups — graduate students encountering the material for the first time and seasoned professionals, often researchers, who have read about these techniques and now wish to employ them. Given the emergence of this field, I don't believe many years will pass before a second edition is necessary. This is perhaps the most essential public health book I have reviewed in some time."—© Doody’s Review Service, 2021, John T. Pierce, MBBS(MD), reviewer, expert opinion

Product details

  • Edition: 1
  • Latest edition
  • Volume: 22
  • Published: October 18, 2020
  • Language: English

About the editors

RF

Rebecca Fry

Dr. Fry is Director of the Institute for Environmental Health Solutions and the Carol Remmer Angle Distinguished Professor in the Department of Environmental Sciences and Engineering at UNC-Chapel Hill. Her lab focuses on understanding how environmental exposures to toxic substances are associated with human disease. With a particular focus on genomic and epigenomic perturbations, her lab uses toxicogenomic and systems biology approaches to identify key molecular pathways that associate environmental exposure with diseases. A current focus in the lab is to study prenatal exposure to various environmental contaminants including arsenic, cadmium, and perflourinated chemicals. Dr. Fry aims to understand molecular mechanisms by which such early exposures are associated with long-term health effects in humans. Ultimately, Dr. Fry’s lab aims to identify mechanisms of contaminant-induced disease and the basis for inter-individual disease susceptibility.
Affiliations and expertise
Carol Remmer Angle Distinguished Professor and Associate Chair, Department of Environmental Sciences and Engineering Director, Institute for Environmental Health Solutions Director, Graduate Studies, UNC Chapel Hill, NC, USA

TO

Trygve O. Tollefsbol

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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