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Elsevier

Epigenetics in Human Disease

  • 2nd Edition - May 18, 2018
  • Latest edition
  • Editor: Trygve O. Tollefsbol
  • Language: English

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders… Read more

Description

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.

Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

Key features

  • Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications
  • Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs
  • Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways
  • Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Readership

Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; advanced undergraduate students, graduate students, university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies

Table of contents

Section I: Introduction

1. Epigenetics in Human Disease

Section II: Methodology

2. Methods and Strategies to Determine Epigenetic Variation in Human Disease

3. Age Estimates Using DNA Methylation Patterns

4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing

Section III: Human Cancer

5. DNA Methylation Alterations in Human Cancers

6. Alterations of Histone Modifications in Cancer

7. MicroRNA in Cancer

8. Epigenetic Approaches to Cancer Therapy

Section lV: Neurological Disease

9. Epigenomics in Neurobehavioral Disease

10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders

11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease

12. Epigenetic Modulation of Human Neurobiological Disorder

Section V: Autoimmune Disease

13. Epigenetic Basis of Autoimmune Disorders in Humans

14. Approaches to Autoimmune Diseases Using Epigenetic Therapy

Section VI: Metabolic Disorders

15. Epigenomic Factors in Human Obesity

16. Epigenetic Approaches to Control Obesity

17. Epigenetics of Diabetes in Humans

18. The Potential of Epigenetic Compounds in Treating Diabetes

Section VII: Other Disorders/Diseases

19. Epigenetic Aberrations in Human Allergic Diseases

20. Therapy of Airway Disease: Epigenetic Potential

21. The Role of Epigenetics in Cardiovascular Disease

22. Epigenetic Treatment Approaches to Cardiovascular Disease

23. Epigenetics and Human Infectious Diseases

24. Therapy of Infectious Diseases Using Epigenetic Approaches

25. The Epigenetics of Endometriosis

26. Epigenetic DNA Methylation in Endometrial Cancer

27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases

Section VIII: Development, Aging and Transgenerational Effects

28. Epigenetics of Transgenerational Inheritance in Disease

29. Epigenetic Mechanisms of Human Imprinting Disorders

30. Therapeutic Approaches to Imprinting Diseases

31. Stem Cell Epigenetics and Human Disease

32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy

33. Aging and Disease: The Epigenetic Bridge

34. Epigenetic Programming of Human Disease and Aging

Section lV: Future Research

35. Future Directions in the Epigenetics of Human Disease

Product details

  • Edition: 2
  • Latest edition
  • Published: May 18, 2018
  • Language: English

About the editor

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Trygve O. Tollefsbol

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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