Essays in Toxicology

List of Contributors

Preface

Contents of Previous Volumes


1. Drug Dependence: Whither the Drug

I. Introduction

II. Mechanism of Tolerance to Barbiturates by Changes in Drug Metabolism

III. Distribution of Barbiturates to the Central Nervous System

IV. Urinary Excretion of Barbiturates

V. Unmasking the Culprit—Heroin

VI. Metabolism of Morphine

VII. Metabolic Transformation of Codeine to Morphine

VIII. Metabolism of Naloxone

IX. Excretion of Narcotics and Metabolites in Urine

X. Transport in Brain

XI. Placental Transfer

XII. Biliary Excretion

XIII. Certain Aspects of Metabolism of Δ°-Tetrahydrocannabinol

References


2. Kinetics of Active-Site-Directed Irreversible Inhibition

I. Introduction

II. Trivial Names and Symbols

III. Origins

IV. Kinetics

References


3. Recondite Toxicity of Trace Elements

I. Introduction

II. Specific Considerations

III. General Conclusions

IV. Recondite Toxicity in Terms of Growth

V. Effects on Body Weights of Aged Animals

VI. Effects of Trace Elements on Survival and Longevity

VII. Effects on Tumors

VIII. Longevity and Median Life-Span

IX. Other Manifestations of Recondite Toxicity

X. Recondite Toxicity of Trace Elements as Expressed by Effects on Reproduction of Rats and Mice

XI. Some Clues to Mechanisms of Toxicity

XII. Production of Chronic Diseases Stimulating Human Disorders

XIII. Recondite Toxicity of Other Metals or Elements in Man

XIV. Innate Toxicity from Water

XV. Summary and Conclusions

References

Author Index

Subject Index