Essays in Toxicology

List of Contributors

Preface

Contents of Previous Volumes


1. Nitrosamines

I. Introduction

II. Discovery of the Carcinogenic Effects of Nitrosamines

III. What May Be Learned from Study of Nitrosamines

References


2. A Laboratory Model Ecosystem to Evaluate Compounds Producing Biological Magnification

I. Introduction

II. Development of a Laboratory System for Evaluation of Micropollutants

III. Problems Investigated

References


3. The Metabolism of DDT in Man

I. Background and Rationale of the Present Study of DDT Metabolism in Man

II. Subjects, Materials, and Methods

III. Absorption and Storage of Ingested DDT

IV. Chemical Conversions of Ingested DDT and DDT Metabolites

V. Relation of Blood Concentrations of DDT Isomers and Metabolites to the Adipose Stores of These Chemicals

VI. Loss of Fat-Stored DDT and DDT Metabolites

VII. Summary and Commentary

References


4. The Toxins of Clostridium botulinum

I. Introduction

II. Nature and Distribution of Clostridium botulinum

III. Toxin Production

IV. Qualitative and Quantitative Assays for Botulinum Toxins

V. Purification and Properties of the Toxins

VI. Studies on the Relation of Functional Groups to Toxicity

VII. Mechanism of Action of the Toxins

VIII. Diagnosis, Treatment, and Prevention of Botulism

References


5. The Use of Breath Analysis in Clinical Toxicology

I. Introduction

II. Technique of Breath Analysis

III. Diagnosis of Exposure

IV. Estimation of the Magnitude of Exposure

V. Illustrative Breath Decay Curves

VI. Illustrative Case Reports

VII. Comment

References


6. The Biochemical Toxicology of Methanol

I. Introduction

II. The Metabolic Disposition of Methanol

III. The Metabolic Disposition of Formaldehyde

IV. The Metabolic Disposition of Formic Acid

V. Summary

References

Author Index

Subject Index