Evaluation of Drug Activities
Pharmacometrics
- 1st Edition - January 1, 1964
- Latest edition
- Editors: D R Laurence, A. L. Bacharach
- Language: English
Evaluation of Drug Activities: Pharmacometrics, Volume 1 provides a review and critical discussion of general and special pharmacological methods used in the search of new drugs.… Read more
Description
Description
Evaluation of Drug Activities: Pharmacometrics, Volume 1 provides a review and critical discussion of general and special pharmacological methods used in the search of new drugs. This book discusses the fundamental difference between a pharmacological study and a bio-assay in the nature of the biological activity. Organized into two parts encompassing 19 chapters, this book begins with an overview of the pharmacological and toxicological studies on animals. This text then discusses the method of producing clinically successful drugs. Other chapters consider the objective of toxicity testing in determining the complications arising from the pharmacological action of the drug and also in discovering any unexpected side-effects. This book discusses as well the pharmacological effects and heredity in laboratory animals. The final chapter deals with the various aspects of hypertensive disease and its treatment. This book is a valuable resource for scientists, biologists, physiologists, pharmacologists, biochemists, physicians, clinicians, and research workers.
Table of contents
Table of contents
List of Contributors
Preface
Symbols and Abbreviations
Part I. General Principles
Chapter 1. First Clinical Trials of Potential Drugs
Chapter 2. A Plan for Evaluating Potential Drugs
Chapter 3. Design, Statistical Analysis and Interpretation
Chapter 4. Strain and Sex Differences ill Response to Drugs
Chapter 5. Some Limitations of Animal Tests
Chapter 6. Toxicity Tests
Chapter 7. Drug Dependence
Part II. Particular Applications
Chapter 8. Analgesics
Chapter 9. Local Anaesthetics
Chapter 10. Tranquillisers and Sedatives
Chapter 11. Antidepressives, Analeptics and Appetite Suppressants
Chapter 12. Hypnotics and General Anaesthetics
Chapter 13. Anticonvulsants
Chapter 14. AntiParkinsonian Agents
Chapter 15. Centrally Acting Skeletal Muscle Relaxants
Chapter 16. Neuromuscular Blocking Agents
Chapter 17. Cardiovascular Activity of Sympathomimetic Amines
Chapter 18. Depressants of Peripheral Sympathetic Nerve Function
Chapter 19. Antihypertensive Agents
Chapter 20. Anticholinesterases
Chapter 21. Histamine Antagonists
Chapter 22. Selective Brain Stem Depressants: Antiemetics, Antitussives, Antihypertensives, Antipyretics
Chapter 23. Agents Acting on the Alimentary Tract
Chapter 24. Agents Acting on the Respiratory Tract
Chapter 25. Iron-containing Haematinics
Chapter 26. Coagulants and Anticoagulants
Chapter 27. Cardioactive Agents
Chapter 28. Diuretics and Antidiuretics
Chapter 29. Biologically Active Polypeptides
Chapter 30. Dermatological Agents
Chapter 31. Agents acting on the Uterus
Chapter 32. Oestrogens, Androgens and Progestagens
Chapter 33. Adrenocorticoid Activity
Chapter 34. Adrenocortical Antagonists
Chapter 35. Thyroxine Analogues (Thyroxine Antagonists and Thyromimetics)
Chapter 36. Antithyroid Agents
Chapter 37. Hypoglycaemic Agents
Chapter 38. Antifertility Agents
Chapter 39. Anti-inflammatory Agents
Chapter 40. Antitumour Agents
Chapter 41. Blood Cholesterol Depressants
Appendix Compositions of some Organ Bath Solutions
Alphabetical Guide To Chapter Contents
Product details
Product details
- Edition: 1
- Latest edition
- Published: January 1, 1964
- Language: English
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