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Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set

  • 12th Edition - July 24, 2024
  • Latest edition
  • Editors: Gary S. Firestein, Iain B. McInnes, Gary Koretzky, Ted Mikuls, Tuhina Neogi, James R. O'Dell
  • Language: English

**Selected for 2026 Doody's Core Titles as an Essential Purchase in Rheumatology**With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment… Read more

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Description

**Selected for 2026 Doody's Core Titles as an Essential Purchase in Rheumatology**

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley’s Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field.

Key features

  • Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment―including key data on outcomes to better inform clinical decision making
  • Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more
  • Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients
  • Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi
  • Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Table of contents

PART 1 Structure and Function of Bone, Joints, and Connective Tissue

1 Developmental Biology, Organization, and Function of the Synovial Joints

2 Synovium

3 Cartilage and Chondrocytes

4 Development and Biology of Bone

5 Muscle Anatomy, Physiology, and Biochemistry

6 Biomechanics

7 Regenerative Medicine and Tissue Engineering

8 Proteinases and Matrix Degradation

PART 2 Cells Involved in Autoimmune Diseases and Inflammation

9 Dendritic Cells

10 Mononuclear Phagocytes

11 Neutrophils

12 T Lymphocytes

13 B Cells

14 Fibroblasts andFibroblast-like Synoviocytes

15 Mast Cells and Basophils

16 Innate Lymphoid Cells and Natural Killer Cells

17 Platelets and Megakaryocytes

PART 3 Effector Mechanisms in Autoimmunity and Inflammation

18 Principles of Signaling

19 Innate Immunity

20 Adaptive Immunity

21 Immune Tolerance and Autoimmunity

22 Pre-clinical Autoimmunity

23 The Microbiome in Rheumatic Diseases

24 Genetics of Rheumatic Diseases

25 Epigenetics of Rheumatic Diseases

26 Complement System

27 Prostaglandins, Leukotrienes, and Related Compounds

28 Angiogenesis

29 Cytokines and Chemokines

30 Neuronal Mechanisms of Pain and Inflammation

PART 4 Broad Issues in the Approach to Rheumatic Disease

31 Clinical Research Methods in the Rheumatic Diseases

32 Epidemiology and Impact of Rheumatic Diseases

33 Assessment of Health Outcomes

34 Biomarkers in Rheumatology

35 Occupational, Environmental, and Recreational Musculoskeletal Disorders

36 Cardiovascular Risk in Inflammatory Rheumatic Disease

37 Cancer Risk in Rheumatic Diseases

38 Occupational Therapy, Physical Therapy, and Rehabilitation

39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment

PART 5 Evaluation of Generalized and Localized Symptoms

40 History and Physical Examination of the Musculoskeletal System

41 Ultrasound in Rheumatology

42 Evaluation of Monoarticular and Polyarticular Arthritis

43 Skin and Rheumatic Diseases

44 The Eye and Rheumatic Diseases

PART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain

45 Neck Pain

46 Shoulder Pain

47 Low Back Pain

48 Hip and Knee Pain

49 Foot and Ankle Pain

50 Hand and Wrist Pain

51 Temporomandibular Joint Disorders

52 Fibromyalgia

PART 7 Diagnostic Tests and Procedures in Rheumatic Diseases

53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology

54 Arthrocentesis and Injection of Joints and Soft Tissues

55 Anti-nuclear Antibodies

56 Autoantibodies in Rheumatoid Arthritis

57 Acute Phase Reactants

58 Imaging in Rheumatic Diseases

PART 8 Pharmacology of Anti-rheumatic Drugs

59 Therapeutic Targeting of Prostanoids

60 Glucocorticoid Therapy

61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies

62 Immunosuppressive Drugs

63 Anti-cytokine Biologics

64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics

65 Janus Kinase and Other Intra-cellular Targets

66 Urate-Lowering Therapy

67 Bisphosphonates

68 Analgesic Agents in Rheumatic Disease

69 Nutrition and Rheumatic Diseases

PART 9 Rheumatoid Arthritis and Sjögren’s Syndrome

70 Etiology of Rheumatoid Arthritis

71 Pathogenesis of Rheumatoid Arthritis

72 Clinical Features of Rheumatoid Arthritis

73 Treatment of Rheumatoid Arthritis

74 Sjögren’s Syndrome

PART 10 Spondyloarthritis

75 Classification and Epidemiology of Spondyloarthritis

76 Axial Spondyloarthritis

77 Reactive Arthritis

78 Psoriatic Arthritis

79 Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies

PART 11 Systemic Lupus Erythematosus and Related Syndromes

80 Etiology and Pathogenesis of Systemic Lupus Erythematosus

81 Clinical Features of Systemic Lupus Erythematosus

82 Treatment of Systemic Lupus Erythematosus

83 Antiphospholipid Syndrome

PART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes

84 Etiology and Pathogenesis of Systemic Sclerosis

85 Clinical Features and Treatment of Scleroderma

86 Inflammatory Diseases of Muscle and Other Myopathies

87 Overlap Syndromes

PART 13 Vasculitis

88 Classification and Epidemiology of Systemic Vasculitis

89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis

90 Anti-neutrophil Cytoplasmic Antibody–Associated Vasculitis

91 Polyarteritis Nodosa

92 Immune Complex–Mediated Small Vessel Vasculitis

93 Primary Central Nervous System Vasculitis

94 Behçet’s Disease

PART 14 Crystal-Induced and Inflammasome-Mediated Inflammation

95 Pathogenesis of Inflammasome-Mediated Diseases

96 Etiology and Pathogenesis of Hyperuricemia and Gout

97 Clinical Features and Treatment of Gout

98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes

99 Familial and Nonfamilial Autoinflammatory Syndromes

PART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders

100 Etiology and Pathogenesis of Osteoarthritis

101 Clinical Features of Osteoarthritis

102 Treatment of Osteoarthritis

103 Metabolic Bone Disease

104 Proliferative Bone Diseases

105 Osteonecrosis

106 Relapsing Polychondritis

107 Heritable Diseases of Connective Tissues

PART 16 Rheumatic Diseases of Childhood

108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis

109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis

110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus

111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis

PART 17 Infections and Rheumatic Disease

112 Bacterial Arthritis

113 Lyme Disease

114 Mycobacterial Infections of Bones and Joints

115 Fungal Infections of Bones and Joints

116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection

117 Viral Arthritis

118 Rheumatic Fever and Post-streptococcal Arthritis

119 COVID-19 and Rheumatic Disease

120 Vaccination in Rheumatic Disease

PART 18 Arthritis Accompanying Systemic Disease

121 Amyloidosis

122 Sarcoidosis

123 Hemochromatosis

124 Hemophilic Arthropathy

125 Rheumatic Manifestations of Hemoglobinopathies

126 IgG4-Related Disease

127 Arthritis Accompanying Endocrine and Metabolic Disorders

128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations

129 Tumors and Tumor-like Lesions of Joints and Related Structures

130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer

Review quotes

5 Stars! "...encompasses everything needed for professionals in rheumatology, providing an easy overview where topics can be readily found. The illustrations are helpful, and the videos included with the book enhance the learning experience. [It] is exceptionally comprehensive, allowing for thorough review of any topic necessary to fully grasp the latest updates in diagnoses and treatments, as well as the fundamental principles of rheumatology. The preface is particularly noteworthy, as it provides a clear overview of the book’s organization and offers a glimpse into the meticulous effort put into each chapter. The overall tone is informative and highly appreciated, ensuring that the audience is well-prepared to delve into the content. It covers a complete list of topics essential for understanding and treating rheumatology conditions, including pathophysiology, clinical manifestations, and treatment options. The book's comprehensive structure offers in-depth coverage across multiple dimensions, with detailed illustrations, high-quality artwork, and informative photographs supporting visual clarity." Review by Joseph Yusin, MD (VA Greater Los Angeles Healthcare System), ©Doody's Review Service 2025. Doody's Score: 100, 5 Stars!

Product details

  • Edition: 12
  • Latest edition
  • Published: October 9, 2024
  • Language: English

About the editors

GF

Gary S. Firestein

Gary Firestein, MD, is a board-certified rheumatologist who diagnoses and treats patients with autoimmune conditions as well as diseases of the joints, muscles and bones. A professor at UC San Diego School of Medicine, Dr. Firestein is distinguished for his research and serves as director of the Altman Clinical and Translational Research Institute and the senior associate vice chancellor for health sciences. Dr. Firestein's research interest focuses on the pathogenesis and treatment of rheumatoid arthritis. Dr. Firestein is the recipient of many awards and honors, including the Arthritis Foundation's Jane Wyman Humanitarian Award in 2010 for his contributions to rheumatology; the Arthritis Foundation Lee C. Howley Sr. Prize for Arthritis Research; and the American College of Rheumatology Distinguished Investigator Award. He has been elected to the American Society for Clinical Investigation and the Association of American Physicians. He has served as an editor for the Textbook of Rheumatology for since the 7th edition (2004).
Affiliations and expertise
Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical and Translational Research Institute, USA

IM

Iain B. McInnes

Iain McInnes is Director of the Institute of Infection, Immunity and Inflammation at the University of Glasgow, UK. He has extensive experience in leading multicenter programs nationally and internationally. He is Director of the Scottish MRC Clinical Pharmacology and Pathology Clinical PhD Training Program, Chief Investigator for the Scottish Early RA Cohort (SERA) and the related SMS-IC biomarker discovery program (PROMISERA), and chief investigator of numerous global phase II and III clinical trials of novel immune therapies. He has served as member or chair of numerous national grant-funding panels and as chair of several European League Against Rheumatism (EULAR) scientific committees – he is now Treasurer and President Elect of EULAR serving on its Steering Committee. He is formerly Chairman of the Foundation for European Rheumatology Research (Foreum) Scientific Committee and leads the EULAR-supported European Roadmap Program that is defining the research agenda for rheumatology for the next decade.
Affiliations and expertise
Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

GK

Gary Koretzky

Gary Koretzky, MD, PhD is Professor of Medicine at Weill Cornell Graduate School. Dr. Koretzky’s research aims to better understand the signal transduction events that occur following engagement of the T cell antigen receptor. He has been continuously funded by the National Institutes of Health since establishing his independent research group, as the laboratory has expanded its interests to study more globally the molecular events important for immune cell development, differentiation and function. Dr. Koretzky has published more than 200 research articles. He is a past President of the American Society of Clinical Investigation (2000) and Councilor of the Association of American Physicians (2008-2012), is a Fellow of the American Association for the Advancement of Science (2004), a member of the Institute of Medicine of the National Academies (2008), a Fellow of the American Academy of Arts & Sciences (2012) and serves as the Editor-in-Chief of Immunological Reviews (2002-present).
Affiliations and expertise
Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics, USA

TM

Ted Mikuls

Dr. Mikuls is a rheumatologist and epidemiologist with research interests focused on the epidemiology, pathogenesis, and outcomes of rheumatoid arthritis (RA) and gout. He is actively engaged in clinical/translational research activities and has received research funding from the NIH, U.S. Department of Defense, Veterans Affairs, the Rheumatology Research Foundation, and industry. He has extensive experience conducting multi-center / multidisciplinary trials, serving as the Principal Investigator (PI) for the multicenter Veterans Affairs Rheumatoid Arthritis (VARA) registry since its inception in 2003. He has served on multiple national study sections including those convened by the NIH, VA, and the Rheumatology Research Foundation. He previously chaired the American College of Rheumatology (ACR) Subcommittee for Practice Guidelines, served on the US FDA’s Arthritis Advisory Committee, and was the Lead Editor for the textbook A Color Handbook – Rheumatology.
Affiliations and expertise
Stokes Shackleford Professor and Vice-Chair for Research, Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, USA

TN

Tuhina Neogi

Tuhina Neogi is a rheumatologist and epidemiologist whose research has focused primarily on risk factors for knee osteoarthritis and gout, pain mechanisms in knee osteoarthritis, as well as methodologic issues of relevance for rheumatic diseases. Dr. Neogi has had continuous peer-reviewed foundation and NIH funding since 2003 and has over 250 peer-reviewed publications to date. She is a past chair of the FDA Arthritis Advisory Committee, serve(d) on the boards of two international societies: Osteoarthritis Research Society International (OARSI) and Gout, Hyperuricemia, and Crystal-Associated Diseases Network (G-CAN), and on committees for the American College of Rheumatology (ACR) and International Association for the Study Pain (IASP), among others. Her work has been recognized with the prestigious 2014 ACR Henry Kunkel Young Investigator Award for outstanding and promising independent contributions to rheumatology research and she has also engaged in developing new classification criteria for a number of rheumatic diseases.
Affiliations and expertise
Section Chief of Rheumatology, Rheumatology, Professor, Rheumatology, Boston University School of Medicine, USA

JO

James R. O'Dell

James R. O’Dell, MD is the Stokes Shackleford Professor of Internal Medicine, Vice-Chairman of Internal Medicine and Chief of the Division of Rheumatology at the University of Nebraska Medical Center (UNMC) in Omaha. Dr. O’Dell founded and has directed the Rheumatoid Arthritis Investigational Network (RAIN) for the last 25 years. Dr. O’Dell is the PI of the large multinational RA research study based at the VA through their cooperative studies program. Dr. O’Dell has published extensively, mostly in the area of rheumatoid arthritis. He has presented frequently at national and international meetings and has more than 100 published articles in top-level rheumatology journals. He has served on numerous American College of Rheumatology (ACR) committees over the last 20 years, including time on both the ACR and REF BOD, as well as a two-year term as President of the Research and Education Foundation of the ACR and was President of the College (2011-2012). Additionally, he is Editor-in-Chief of Up To Date for Rheumatology.
Affiliations and expertise
Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska, USA