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Elsevier

Gender Affirming Hormone Therapy in Humans

Evidence from Murine Models

  • 1st Edition - December 1, 2026
  • Latest edition
  • Editor: Jeffrey David Zajac
  • Language: English

Gender Affirming Hormone Therapy in Humans: Evidence from Murine Models is an unprecedented reference for scientists, researchers, students and anyone interested in this field… Read more

Description

Gender Affirming Hormone Therapy in Humans: Evidence from Murine Models is an unprecedented reference for scientists, researchers, students and anyone interested in this field of research. The book is a review of the current state of mouse animal models of relevance to transgender health. It's divided into chapters specific for different tissues in which mouse models are described and their relevance to human health is discussed. This is a novel reference summarizing what these models demonstrate about the benefits and risks of GAHT and the most effective and lowest risk approach to treatment. The models suggest applications of this research to human studies and treatment of transgender people. There is an expanding number of transgender people with are few evidence based books that address this field relating to the importance and growing role of murine models.

Key features

  • Provides hot topics in cross gender hormone effects on the body
  • Presents the most cutting-edge research models for future research innovation
  • Includes science-based evidence and studies relevant to transgender research
  • Highlights potential clinical approaches for the use of GAHT based on relevant up-to-date animal data

Readership

Research scientists interested in up-to-date reference material about transgender animal models, clinicians with an interest in treating transgender patients wanting relevant scientific data for designing human trials or treating patients

Table of contents

1. Introduction to transgender animal models, advantages and disadvantages and relevance to humans

2. Male to Female and Female to Male models, controls

3. Cross gender hormone effects on bone

4. Cross gender hormone effects on the CVS and blood pressure

5. Cross gender hormone effects on the immune system

6. Cross gender hormone effects on muscle

7. Cross gender hormone effects on body composition

8. Cross gender hormone effects the kidney

9. Cross gender hormone effects on wound healing

10. Cross gender hormone effects on the CNS

11. Conclusion

Product details

  • Edition: 1
  • Latest edition
  • Published: December 1, 2026
  • Language: English

About the editor

JZ

Jeffrey David Zajac

Jeffrey Zajac is Professor and Head of the University of Melbourne and Chair of Department of Medicine at Austin Health. He is a Clinical Endocrinologist and General Physician with research interests in molecular endocrinology.

Professor Zajac trained in Medicine at the University of Melbourne and undertook a PhD. Following postdoctoral work in the Endocrine Genetics Unit at Massachusetts General Hospital, Boston, he returned to the University of Melbourne initially at Royal Melbourne Hospital and now Austin Health. His research group has embarked on a major research program investigating the effect of androgen deprivation therapy in patients with prostate cancer. These investigations include effects on bone, muscle, cardiovascular risk and metabolic state. He also heads a molecular endocrinology group investigating the androgen receptor using genetically modified mice. His clinical interests include general endocrinology, the use, misuse and abuse of testosterone, and transgender medicine.

Affiliations and expertise
Professor and Head, University of Melbourne, Australia