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Genome Editing for Neurodegenerative Diseases

From Concept to Clinical Trials

  • 1st Edition - October 17, 2024
  • Latest edition
  • Editors: Sandeep Kumar Singh, Amarish Kumar Yadav, Burkhard Poeggeler, George Perry
  • Language: English

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical… Read more

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Description

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.

Key features

  • Covers basic mechanisms of genome-editing tools and their therapeutic potential
  • Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases
  • Includes research on genome-editing tool development, from basic concept to clinical trials

Readership

Researchers in neuroscience, biopharmaceuticals, clinicians working with neurodegenerative diseases, Potential overlap for graduate students studying neurodegenerative diseases and neurodegenerative disease therapy

Table of contents

Introduction
Burkhard Poeggeler

1. Therapeutic potential of genome editing tools in neurodegenerative diseases
Ankur Kumar, Nandigam Pardhipa, Sachin G. Swami, Vibha Dwivedi and Anand K. Singh

2. Genetic and molecular basis of neurodegenerative diseases
Sunanda Yogi, Anjali Sangeeth, Anuradha Venkatakrishnan Chimata, Radhika Padma and Amit Singh

3. Genome editing tools: principles, structures, and mechanisms
Rayees Ahmad Naik, Mehak Naseer Mir, Roshni Rajpoot, Sonalika Singh, Kusum Singh and Sandeep Kumar Singh

4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseases
Shailendra Kumar Mishra, Hung-Ming Chang, Ahmad A. Obaid and Sandeep Kumar Singh

5. Use of CRISPR system in genetic screening to detect neurodegenerative disease
Koyel Kar

6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseases
Josephine Esposto

7. Transgene delivery system: viral, nonviral, and other methods for central nervous system
Bhupender Sahu, Bibhudendu Behera and Umesh Kumar

8. Gene therapies for neurodegenerative disease: current knowledge and challenges
Bhumi Arora, Sakshi Garg, Aditya Shrivastav, Mrinalini Sharma, Bhupender Sahu and Umesh Kumar

9. Gene therapy under clinical trials for neurodegenerative diseases
Bhupender Sahu, Lakshita Tyagi, Prshant Tyagi and Umesh Kumar

10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics
Burkhard Poeggeler

Product details

  • Edition: 1
  • Latest edition
  • Published: October 17, 2024
  • Language: English

About the editors

SS

Sandeep Kumar Singh

Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.

Affiliations and expertise
Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India

AY

Amarish Kumar Yadav

Dr. Amarish K Yadav is a postdoctoral research scholar at North Carolina State University. His current research interest is developing gene-drive systems using CRISPR/Cas9 in Drosophila suzukii. After obtaining his master’s degree in biotechnology, he was awarded his Ph.D. from Banaras Hindu University in 2017. He has worked in collaboration with many neuroscientists and researchers to understand the molecular mechanisms of Alzheimer’s and Parkinson’s diseases progression and therapeutics. Dr. Yadav has published his research findings in peer-reviewed journals and has also authored a book chapter on neurodegenerative diseases modeling in drosophila. Dr. Yadav has participated and presented his research work at various national and international conferences and symposia.
Affiliations and expertise
Dept. of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA

BP

Burkhard Poeggeler

Dr. Burkhard Poeggeler (Georg-August-University of Göttingen, Germany) holds a PhD in Biochemistry and has authored over 120 PubMed-indexed publications. His research focuses on neuroprotection, redox biology, and regenerative pharmacology.
Affiliations and expertise
Department of Biology and Psychology, Georg-August-University Göttingen, Germany

GP

George Perry

Dr. George Perry, Ph.D. Professor of Biology and Chemistry Semmes Foundation Distinguished University Chair in Neurobiology He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.
Affiliations and expertise
Department of Biology, The University of Texas at San Antonio, University of Texas, San Antonio, TX, USA

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