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Genome Stability

From Virus to Human Application

  • 2nd Edition, Volume 26 - July 17, 2021
  • Latest edition
  • Editors: Igor Kovalchuk, Olga Kovalchuk
  • Language: English

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability… Read more

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Description

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.

This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding　field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

Key features

  • A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects
  • Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability
  • Contains applications of genome instability research and outcomes for human disease
  • Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Readership

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics. Clinicians and graduate students in the biosciences

Table of contents

1. Genome stability: An evolutionary perspective

Part I Genome instability of viruses

2. Genetic instability of RNA viruses

3. Genome instability in DNA viruses

Part II Genome instability in bacteria and archaea

4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability

5. Genome instability in bacteria: Causes and consequences

6. CRISPR – Bacterial immune system

Part III Genome stability of unicellular eukaryotes

7. From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules

8. Homologous recombination and nonhomologous end-joining repair in yeast

Part IV Genome stability in multicellular eukaryotes

9. Meiotic and mitotic recombination: First in flies

10. Genome stability in Drosophila: Mismatch repair and genome stability

11. Genome stability in Caenorhabditis elegans

12. Plant genome stability—General mechanisms

13. Genetic engineering in plants using CRISPRs

Part V Genome stability in mammals

14. Cell cycle control and DNA-damage signaling in mammals

15. The role of p53/p21/p16 in DNA damage signaling and DNA repair

16. Roles of RAD18 in DNA replication and post-replication repair (PRR)

17. Base excision repair and nucleotide excision repair

18. DNA mismatch repair in mammals

19. Repair of double-strand breaks by nonhomologous end joining; Its components and their function

20. Homologous recombination in mammalian cells: From molecular mechanisms to pathology

21. Telomere maintenance and genome stability

22. Chromatin, nuclear organization and genome stability in mammals

23. Role of DNA mthylation in genome stability

24. Non-coding RNAs in genome integrity

Part VI
Human diseases associated with genome instability

25. Human diseases associated with genome instability

26. Cancer and genomic instability

27. Epigenetic regulation of the cell cycle & DNA-repair in cancer

28. Genomic instability and aging: Causes and consequences

29. The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability

Part VII Effect of environment on genome stability

30. Diet and nutrition

31. Chemical carcinogens and their effect on genome and epigenome stability

32. Modern sources of environmental ionizing radiation exposure and associated health consequences

Part VIII Bystander and transgenerational effects: Epigenetic perspective

33. Sins of fathers through a scientific lens: Transgenerational effects

34. Radiation and chemical induced genomic instability as a driver for environmental evolution

35. Transgenerational genome instability in plants

36. Methods for the detection of DNA damage

37. Conserved and divergent features of DNA repair. Future perspectives in genome stability research

38. Off-target effects in genome editing

Product details

  • Edition: 2
  • Latest edition
  • Volume: 26
  • Published: July 22, 2021
  • Language: English

About the editors

IK

Igor Kovalchuk

Dr. Igor Kovalchuk is the Principle Investigator in the Plant Biotechnology laboratory at the University of Lethbridge. His lab studies genetic and epigenetic regulation of plant response to stress as well as develops various methods for improvement of plant transformation. He is particularly interested in the transgenerational effects of stress and microevolution of plant stress tolerance/resistance.

He has substantial expertise in plant stress tolerance and plant transgenesis.

Affiliations and expertise
Principle Investigator, Planet Biotechnology Laboratory, University of Lethbridge, Lethbridge, AB, Canada

OK

Olga Kovalchuk

Dr. Olga Kovalchuk is the Principle Investigator of the Human Epigenetics laboratory at the University of Lethbridge. Her lab studies the role of epigenetic dysregulation in carcinogenesis, epigenetic regulation of the cancer treatment responses, radiation epigenetics and the role of epigenetic changes in genome stability and carcinogenesis, radiation-induced oncogenic signaling, and radiation-induced DNA damage, repair, and recombination.
Affiliations and expertise
Principle Investigator, Human Epigenetics Laboratory, University of Lethbridge, Lethbridge, AB, Canada

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