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Elsevier

Geographic Atrophy in Age-related Macular Degeneration

  • 1st Edition - October 15, 2026
  • Latest edition
  • Editors: Jay Chhablani, Caroline R. Baumal
  • Language: English

Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinic… Read more

Description

Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.

Additionally, it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

Key features

  • Provides up-to-date knowledge, consolidating the latest advancements and established knowledge in the diagnosis, differential diagnoses, and treatment of geographic atrophy in age-related macular degeneration
  • Acts as a comprehensive resource, providing a thorough and integrated overview of available data, making it an essential guide for clinicians, researchers, and anyone seeking a deep understanding of GA in AMD
  • Offers practical insights, guidance, and actionable information for both medical professionals and patients, thus enhancing patient care and supporting informed decision-making

Readership

Practicing ophthalmologists and retina specialists (both medical and surgical). This includes clinicians seeking to stay updated with the latest advancements in diagnostic techniques, differential diagnoses, and emerging treatments, as well as those who are looking to integrate cutting-edge research findings into their clinical practice to improve patient outcomes

Table of contents

1. Definitions

2. Histopathology and mechanisms

3. Epidemiology and risk factors including genetics

4. Non-dye-based imaging, Fundus photo, IR, FAF

5. OCT

6. OCTA

7. Dye-based imaging (FA, ICG)

8. Visual Function test (electrophysiology, dark adaptation, etc)

9. Differential diagnosis and masquerades

10. GA progression

11. GA association with CNV

12. Role of AI in diagnosis and follow-up

13. GA management (prevention, old treatments, new treatments with side effects, Visual cycle modulators, mTOR inhibitors, complement inhibitors, MMP inhibitors, LDL lowering drugs, Anti-amyloid beta, Antioxidants and neuroprotectants; Choroidal perfusion enhancers

14. GA management (Surgical approaches)

15. Failed approaches in GA

16. Learnings from GA clinical trials

17. Burden of disease, visual rehabilitation, Psychosocial Impact

18. Personalized medicine in GA: The future is here

Product details

  • Edition: 1
  • Latest edition
  • Published: October 15, 2026
  • Language: English

About the editors

JC

Jay Chhablani

Jay Chhablani MD is Professor of Ophthalmology and vitreo-retina surgeon at the University of Pittsburgh Eye Center, USA. He established the “Choroid Analysis and Research (CAR) Lab,” which focuses on computational as well as biological research in the field of choroid. He has published more than 650 articles in peer-reviewed journals with a focus in the field of choroid. He is the editor of books “Choroidal Disorders,” “Central Serous Chorioretinopathy” and “Choroidal Neovascularization.” He is on the editorial board of several journals, including the American Journal of Ophthalmology. He has won several national and international awards and delivered named lectures.

Affiliations and expertise
UPMC Vision Institute, USA

CB

Caroline R. Baumal

As a board-certified ophthalmologist, Caroline R. Baumal MD, FASRS has authored over 170 publications and has been recognized with numerous prestigious awards, including the Senior Achievement Award from the American Academy of Ophthalmology, the Crystal Apple Award from the American Society of Retina Specialists, and the Lifetime Achievement Award from the Vit-Buckle Society. She also has been involved with research and clinical trials investigating novel therapies for retinal diseases. Caroline studied biochemistry at McGill University and received an MD from the University of Toronto, where she also completed her ophthalmology residency followed by two fellowships: Retinal Surgery at Wills Eye Hospital and Medical Retinal and Lasers at New England Eye Center.

Affiliations and expertise
Apellis Pharmaceuticals, USA