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Elsevier

Handbook of Epigenetics

The New Molecular and Medical Genetics

  • 3rd Edition - September 8, 2022
  • Latest edition
  • Editor: Trygve O. Tollefsbol
  • Language: English

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical applicati… Read more

Description

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.

In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.

Key features

  • Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics
  • Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine
  • Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout
  • Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction
  • Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

Readership

Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies. Advanced undergraduate and graduate students; clinicians

Table of contents

1. Epigenetics Overview

SECTION I: Molecular Mechanisms of Epigenetics

2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development

3. Mechanisms of Histone Modification

4. The Epigenetics of Non-coding RNA

5. Prions and Prion-like Phenomena in Epigenetic Inheritance

6. Higher-order Chromatin Organization in Diseases

7. Polycomb-group Proteins and Epigenetic Control of Gene Activity

SECTION II: Methods in Epigenetics

8. Methods for Assessing DNA Cytosine Modifications Genome-wide

9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome

10. Techniques for Genome-wide Expression of Non-coding RNA

11. Computational Epigenetics

SECTION III: Model Organisms of Epigenetics

12. Epigenetics of Lower Organisms

13. Drosophila Epigenetics

14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies

15. Plant Epigenomics

SECTION IV: Factors Influencing Epigenetic Changes

16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions

17. Epigenetic Biomarkers

18. Transposable elements shaping the epigenome

19. Metabolic Regulation of DNA Methylation in Mammalian Cells

20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications

21. Epigenetics, Stem Cells and Cellular Differentiation

22. Regeneration Epigenetics

23. Epigenetics of X-chromosome Inactivation

24. Epigenetics of Memory Processes

25. Transgenerational Epigenetics

26. DNA Methylation Clocks in Age-related Disease

SECTION V: Evolutionary Epigenetics

27. Evolution of Epigenetic Mechanisms in Plants

28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation

29. Adaptive Evolution and Epigenetics

SECTION VI: Epigenetic Epidemiology

30. Epigenetics of Livestock Breeding

31. Nutritional Epigenetics and Metabolic Syndrome

32. Epigenetics of Drug Addiction

33. Environmental Influence of Epigenetics

34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease

35. Population Pharmacoepigenomics

SECTION VII: Epigenetics and Human Disease

36. Cancer Epigenetics

37. The Role of Epigenetics in Autoimmune Disorders

38. Epigenetics of Brain Disorders

39. The Epigenetics of Metabolic Diseases

40. Imprinting Disorders in Humans

SECTION VIII: Epigenetic Therapy

41. DNA Demethylating Agents in Clinical Medicine

42. Clinical Applications of Histone Deacetylase Inhibitors

43. Combination Epigenetic Therapy

SECTION XI: The Future of Epigenetics

44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

Product details

  • Edition: 3
  • Latest edition
  • Published: September 8, 2022
  • Language: English

About the editor

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Trygve O. Tollefsbol

Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USA

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