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Elsevier

Handbook of Proteolytic Enzymes

Serine and Threonine Peptidases

  • 4th Edition - September 1, 2026
  • Latest edition
  • Editor: Neil D. Rawlings
  • Language: English

The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocat… Read more

Description

The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocatalysis since the first edition published in 1998. Extensively updated, the new edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

This volume includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Key features

  • Provides the only comprehensive book on serine and threonine peptidases, with over 400 peptides included
  • Written by experts in their field, including updates on proteolytic enzymes from all groups of living organisms and viruses, and some that are major targets of pharmaceutical research
  • Presents a fully searchable text, with 2D and 3D structures of peptidases in color and links to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research and discusses recent drug trials

Readership

Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology, clinician scientists, researchers in industry and pharma, Students of biochemical sciences, clinicians across disease specialties

Table of contents

New Chapters

1. Transmembrane Peptidase, Serine 4

2. Mesotrypsin

3. Kallikrein-Related Peptidase 6

4. Arginyl Peptidase

5. HtrA Peptidase (Helicobacter)

6. HtrA Peptidase (Borrelia burgdorferi)

7. Zika Virus NS2B-NS3 Peptidase

8. Keratinase K1 (Stenotrophomonas maltophilia)

9. Mycosin-1

10. Dipeptidylpeptidase Homologue DPP6

11. ClpP1 Peptidase (Streptomyces)

12. ClpP2 Peptidase (Streptomyces)

Major Revisions

13. Chymotrypsin A (Cattle-Type)

14. Granzyme B (Homo sapiens-Type)

15. Tryptase Beta

16. Kallikrein-Related Peptidase 3

17. Kallikrein-Related Peptidase 5

18. Kallikrein-Related Peptidase 7

19. Corin

20. Factor VII-Activating Peptidase

21. Trypsin 1

22. Cationic Trypsin (Homo sapiens-Type)

23. Elastase-2

24. Cathepsin G

25. Myeloblastin

26. Chymase (Homo sapiens-Type)

27. Prostasin

28. Mesotrypsin

29. Coagulation Factor VIIa

30. Coagulation Factor IXa

31. Coagulation Factor Xa

32. Coagulation Factor XIa

33. Coagulation Factor XIIa

34. Thrombin

35. Plasma Kallikrein

36. Urokinase-Type Plasminogen Activator

37. t-Plasminogen Activator

38. Plasmin

39. Hepsin

40. Epitheliasin

41. Matriptase

42. Matriptase-2

43. HtrA1 Peptidase (Homo sapiens-Type)

44. HtrA2 Peptidase

45. Flavivirin

46. Hepacivirin

47. Bacterial Proteasome, Beta Component

48. Proteasome Subunit Beta1c

49. Proteasome Subunit Beta2c

50. Proteasome Subunit Beta5c

51. Proteasome Subunit Beta1i

52. Proteasome Subunit Beta5i

53. Taspase-1

54. Subtilisin Carlsberg

55. PfSUB1 Peptidase

56. PCSK1 Peptidase

57. PCSK9 Peptidase

58. Site-1 Peptidase

59. Furin

60. Tripeptidyl-Peptidase I

61. Prolyl Oligopeptidase

62. Dipeptidyl-Peptidase IV (Eukaryote)

63. Fibroblast Activation Protein Alpha Subunit

64. Dipeptidyl-Peptidase 9

65. Serine Carboxypeptidase A

66. Lysosomal Pro-Xaa Carboxypeptidase

67. Signal Peptidase I

68. Lon-A Peptidase

69. PIM1 Peptidase

70. Peptidase Clp (Type 1)

Product details

  • Edition: 4
  • Latest edition
  • Published: September 1, 2026
  • Language: English

About the editor

NR

Neil D. Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
Affiliations and expertise
Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK