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Handbook of Proteolytic Enzymes

Volume 4: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms

  • 4th Edition - September 1, 2026
  • Latest edition
  • Editor: Neil D. Rawlings
  • Language: English

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Four: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms inclu… Read more

Description

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Four: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms includes over 250 chapters on known aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms. Chapters discuss each enzyme’s name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Edited by world-renowned experts, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Key features

  • Provides a comprehensive book on aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms
  • Written by experts on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research
  • Presents fully searchable text and color 2D and 3D structures of peptidases, with direct links to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research and discusses recent drug trials

Readership

Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma

Table of contents

I. New Chapters

1. Candidapepsin SAP2

2. Signal Peptide Peptidase-Like Protein 2A

II. Major Revisions

3. Pepsin A

4. Chymosin

5. Renin

6. Cathepsin D

7. Cathepsin E

8. Phytepsin

9. Plasmepsin-2

10. BACE1 g.p. (Homo sapiens)

11. BACE2 g.p. (Homo sapiens)

12. HIV-1 Retropepsin

13. Presenilin 1

Product details

  • Edition: 4
  • Latest edition
  • Published: September 1, 2026
  • Language: English

About the editor

NR

Neil D. Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
Affiliations and expertise
Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK