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Elsevier

Handbook of Proteolytic Enzymes

Cysteine Peptidases

  • 4th Edition - September 1, 2026
  • Latest edition
  • Editor: Neil D. Rawlings
  • Language: English

Handbook of Proteolytic Enzymes: Cysteine Peptidases, Fourth Edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and indus… Read more

Description

Handbook of Proteolytic Enzymes: Cysteine Peptidases, Fourth Edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. It includes over 300 chapters on known cysteine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of peptidases, extensive references, and links to PubMed and MEROPS databases.

Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Key features

  • Provides a comprehensive book on cysteine peptidases, with over 300 peptides included
  • Written by experts in their field, and covering proteolytic enzymes from all groups of living organisms and viruses
  • Includes candidates that are currently major targets of pharmaceutical research
  • Presents a fully searchable text, color 2D and 3D structures of peptidases, and direct links to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research and discusses recent drug trials

Readership

Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology, clinician scientists, researchers in industry and pharma Students of biochemical sciences, clinicians across disease specialties

Table of contents

New Chapters

1. Pseudotzain

2. Falcipain-2

3. Falcipain-3

4. Rhodesain

5. OTULIN Peptidase

6. Ubiquitinyl Hydrolase-BAP1

7. Butelase 1

8. CED-3 Peptidase

9. Caspase-11

10. Metacaspase-9

11. Middle East Respiratory Syndrome Coronavirus Papain-Like Peptidase

12. Ubiquitin-Specific Peptidase 9X

13. Ubiquitin-Specific Peptidase 11

14. Ubiquitin-Specific Peptidase 12

15. Ubiquitin-Specific Peptidase 18

16. Ubiquitin-Specific Peptidase 19

17. Ubiquitin-Specific Peptidase 20

18. Ubiquitin-Specific Peptidase 21

19. Ubiquitin-Specific Peptidase 26

20. Ubiquitin-Specific Peptidase 28

21. Ubiquitin-Specific Peptidase 30

22. Ubiquitin-Specific Endopeptidase 39

23. MERS Coronavirus Picornain 3C-Like Peptidase

24. D-Alanyl-Glycyl Peptidase

25. Autophagin-1

26. DJ-1 Putative Peptidase

Major Revisions

27. Papain

28. Stem Bromelain

29. Actinidin

30. Cathepsin B

31. Cathepsin K

32. Cathepsin L

33. Cathepsin S

34. Cathepsin X

35. Falcipain-2

36. Falcipain-3

37. Dipeptidyl-Peptidase I

38. Peptidase 1 (Mite)

39. Cruzipain

40. Calpain-1

41. Calpain-2

42. Calpain-3

43. Streptopain

44. Ubiquitinyl Hydrolase-L1

45. Severe Acute Respiratory Syndrome Coronavirus Papain-Like Peptidase

46. Ubiquitin-Specific Peptidase 4

47. Ubiquitin-Specific Peptidase 7

48. Ubiquitin-Specific Peptidase 15

49. Legumain (Plant Beta Form)

50. Legumain, Animal-Type

51. Caspase-1

52. Caspase-3

53. Caspase-7

54. Caspase-8

55. Caspase-9

56. Gingipain K

57. Separase (Homo sapiens-Type)

58. Sindbis Virus-Type nsP2 Peptidase

59. Enterovirus Picornain 2A

60. Tobacco Etch Virus NIa Peptidase

61. SARS Coronavirus Picornain 3C-Like Peptidase

62. Calicivirin

Product details

  • Edition: 4
  • Latest edition
  • Published: September 1, 2026
  • Language: English

About the editor

NR

Neil D. Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
Affiliations and expertise
Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK