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Elsevier

Handbook of Proteolytic Enzymes

Volume 5: Inhibitors of Proteolytic Enzymes

  • 4th Edition - September 1, 2026
  • Latest edition
  • Editor: Neil D. Rawlings
  • Language: English

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Five: Inhibitors of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists, and molecular biologist… Read more

Description

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Five: Inhibitors of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. This volume offers a thorough discussion of known naturally-occurring and synthetic inhibitors of proteolytic enzymes. Each chapter includes enzyme inhibitor names, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of inhibitors, extensive references, and links to PubMed and MEROPS databases.

Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Key features

  • Provides a comprehensive book on naturally-occurring and synthetic inhibitors of proteolytic enzymes
  • Written by experts in their field, and covering proteolytic enzymes from all groups of living organisms and viruses
  • Includes candidates that are currently major targets of pharmaceutical research
  • Presents a fully searchable text, color 2D and 3D structures of peptidases, and direct links to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research and discusses recent drug trials

Readership

Primary market/audience: Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma

Secondary market/audience: Students of biochemical sciences; clinicians across disease specialties

Table of contents

1. Protein Inhibitors and Their Clans

2. Mechanisms of Inhibition

3. SPINK1

4. Aprotinin

5. Alpha-1-Peptidase Inhibitor

6. Antithrombin

7. Plasminogen Activator Inhibitor-1

8. C1 Inhibitor

9. SerpinA12

10. Sunflower Cyclic Trypsin Inhibitor

11. Elafin

12. Cystatin B

13. Cystatin C

14. Cystatin F

15. Phytocystatin

16. Timp-1

17. Timp-2

18. Alpha-2-Macroglobulin

19. SPINK5 Protein

20. Tissue Factor Pathway Inhibitor-1

21. Hepatocyte Growth Factor Activator Inhibitor Type 2

22. Secretory Leukocyte Peptidase Inhibitor

23. Calpastatin

24. Synthetic Inhibitors of Metallopeptidases

25. Synthetic Inhibitors of Cysteine Peptidases

26. Synthetic Inhibitors of Serine Peptidases

27. Synthetic Inhibitors of Other Peptidases

Product details

  • Edition: 4
  • Latest edition
  • Published: September 1, 2026
  • Language: English

About the editor

NR

Neil D. Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.
Affiliations and expertise
Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK