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Elsevier

Haschek and Rousseaux's Handbook of Toxicologic Pathology

  • 3rd Edition - May 1, 2013
  • Latest edition
  • Editors: Wanda M Haschek, Brad Bolon, Colin G. Rousseaux, Ricardo Ochoa, Matthew A. Wallig
  • Language: English

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pha… Read more

Description

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

Key features

  • Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Readership

Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories

Table of contents

Volume 1: General Toxicologic PathologyPrefaceContributorsPart A: Basics of Toxicologic PathologyToxicologic Pathology: An IntroductionBiochemical Basis of ToxicityMorphologic Manifestation of Toxic Cell InjuryOrganelle Biochemistry and Regulation of Cell DeathCarcinogenesisApplied Clinical Pathology in Preclinical Toxicology TestingNomenclaturePart B: The Practice of Toxicologic PathologyBasic TechniquesManaging Pitfalls in Toxicologic PathologySpecial Techniques in Toxicologic PathologyApplication of New Technologies to Toxicologic PathologyIssues in Laboratory Animal Science for the Toxicologic PathologistNew Animal Models in ToxicologyPathology Issues in the Design of Toxicology StudiesUse and Misuse of Statistics in the Design and Interpretation of StudiesPreparation of the Report for a Toxicology/Pathology StudyPart C: Selected Topics in Toxicologic PathologyRisk Assessment: The Changing ParadigmPrinciples of Risk Communication: Building Trust and Credibility with the PublicBiomedical Devices and BiomaterialsBiotechnology and Its ProductsEndocrine DisruptorsRadiation and HeatNutritional Toxicologic PathologyPhycotoxinsMycotoxinsHeavy MetalsVolume 2: Organ Specific Toxicologic PathologyOrgan-Specific Toxicologic Pathology: An IntroductionRespiratory SystemSkin and Oral MucosaGastrointestinal TractLiverPancreasKidneyLower Urinary TractCardiovascular and Skeletal Muscle SystemsBones and JointsNervous SystemThe EyeImmune SystemHematopoietic SystemEndocrine SystemMale ReproductionFemale ReproductionEmbryo and FetusIndex

Review quotes

"…the long awaited third edition of this well-respected and essential contributor to toxicological pathology, toxicology and other biological and medical disciplines has been published. It is now presented in three volumes instead of two, and benefits tremendously from having colour illustrations throughout. It is straight forward to read and is laid out in a logical format."—btsNews, June 2014

"..this is the most comprehensive textbook yet published covering the various aspects of toxicological pathology in general, and it does a fair job in covering toxicology topics as well. Its scope and breadth of coverage will find it well placed within any toxicology laboratory and I cannot recommend it more highly. It should take pride of place in the library of any toxicology laboratory and should be an indispensable text for pathologists and toxicologists…"—Toxicologic Pathology, January 31, 2014

"Occasionally, a book becomes available that sets a new standard for a subspecialty, and such is the case for the third Edition…This substantially sized…and exceptionally compiled and useful book gathers extensive knowledge from the field of toxicologic pathology as well as tangential and integrative areas…the third edition of this handbook lends itself to being a reference book that reads like an accessible and helpful textbook."—Veterinary Pathology, Vol 51(1), 2014

"The 3 volumes are well organized, and the editors have endeavored to provide clearer and more complete content description for chapter titles that will be easier for nonpathologist to recognize.…This…handbook belongs on the physical- or e-shelf of practitioners of toxicologic pathology and toxicology and needs to be in the communal library of a broad range of individuals in life sciences who interact with toxicologic pathologists."—International Journal of Toxicology, December 2, 2013

"The 2 volumes are excellent companions that complement each other as a "1,2"punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."—VETERINARY AND HUMAN TOXICOLOGY (October 2002)

"...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."—Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)

"...very readable, well-referenced, and current...an excellent book for research training."—DOODY'S

Product details

  • Edition: 3
  • Latest edition
  • Published: June 17, 2013
  • Language: English

About the editors

WM

Wanda M Haschek

Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.
Affiliations and expertise
Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

BB

Brad Bolon

Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

CR

Colin G. Rousseaux

Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa Principal, Colin Rousseaux and Associates, Canada

RO

Ricardo Ochoa

Affiliations and expertise
Pre-Clinical Safety Inc.

MW

Matthew A. Wallig

Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.
Affiliations and expertise
Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

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