HIV-Associated Neurocognitive Disorders
- 1st Edition - February 21, 2024
- Latest edition
- Editors: Guoku Hu, Huangui Xiong, Shilpa Buch
- Language: English
HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the… Read more
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Description
Description
HIV-Associated Neurocognitive Disorders (HAND) presents a complex and evolving challenge in the context of HIV-1 infection and treatment. This comprehensive volume dives into the clinical manifestations, molecular and cellular mechanisms, and therapeutic strategies underlying HAND and its associated comorbidities. This book brings together cutting-edge research and clinical insights, making it an essential resource for researchers, clinicians, and students engaged in HIV-related studies and neurocognitive research. This resource also aims to advance our understanding of HAND to contribute to the development of novel diagnostic tools and therapeutic interventions for improved patient outcomes.
Key features
Key features
- Provides an in-depth exploration of the clinical manifestations of HAND and its comorbidities
- Includes detailed assessments of the molecular and cellular mechanisms underlying HAND symptoms
- Examines animal models for studying HAND, including macaque and rodent models
- Presents insights into epigenetic regulation and signaling pathways implicated in HAND
- Covers prevention, therapeutic strategies, and diagnostic approaches
Readership
Readership
Neuroscientists, clinicians, neurologists, graduate students in these areas
Table of contents
Table of contents
Foreword
Howard E. Gendelman
1. An overview of the mechanisms of HIV-1 infection, latency, pathogenesis, and eradication strategies from the CNS
Mudit Tyagi
2. Central Nervous System Complications of Human Immunodeficiency Virus Infection
Howard E. Gendelman
3. Health LIteracy in HIV-associated Neurocognitive Disorders
Ilex Beltran-Najera, Steven Paul Woods, Darrian Evans, Andrea Mustafa, Anastasia Matchanova and Jennifer Thompson
4. Neuroimaging insights into the CNS effects of HIV infection
Christine Fennema-Notestine and Amanda Bischoff-Grethe
5. Early and upstream subcellular organellar events associated with HAND
Jonathan D. Geiger, Peter W. Halcrow, Nimal Kumar and Darius Quansah
6. White matter loss and oligodendrocyte dysfunction in HAND
Judith B. Grinspan and Kelly L. Jordan-Sciutto
7. Pathogenesis of HIV-associated pain
Xin Liu and Shao-Jun Tang
8. Neuropathogenesis of HIV-associated neuropathic pain
Shuanglin Hao
9. Neuropathic Pain in HIV and the role of the Autophagy pathway
Myosotys Rodriguez, Marissa Pokharel, Florida Owens, Jay McLaughlin and Nazira El-Hage
10. Host peripheral immune dynamics increase HIV-associated neurocognitive disorders incidence and progression
Siddappa N. Byrareddy
11. The role of immunometabolism in HIV associated depression and cognitive impairment
Ronald J. Ellis and Mohammadsobhan Andalibi
12. Role of extracellular viral regulatory proteins in neuropathogenesis
Michael Nonnemacher, Rachel Berman, Jill Lawrence, Collins MacKenzie, Ted Gurrola, William Dampier and Brian Wigdahl
13. Role of inflammasomes in HIV-1 and drug abuse-mediated neuroinflammation
Shilpa Buch and Palsamy Periyasamy
14. The Contribution of Myeloid Cells to HIV Neuropathogenesis
Veronica Veksler, Tina M. Calderon and Joan W. Berman
15. Immunophilin ligands modulate phagocytosis and viral replication in HIV-infected macrophages
Anish Vinay Sathe, Ana Sanchez, Benchawanna Soontornniyomkij, Mary Swinton, Shibangi Pal and Cristian Achim
16. Immunometabolic mechanisms of HIV-associated neurocognitive disorders and traumatic brain injury: Commonalities and contrasts between chronic and acute neurodegenerative pathologies
Jacqueline Kulbe and Jerel Adam Fields
17. Endolysosome dysfunction in HAND
Wendie Hasler, Neda Rezagholizadeh and Xuesong Chen
18. Evolving biomarkers for HIV-associated neurocognitive disorders (HAND)
LYNN PULLIAM
19. Intracellular immunity against HIV infection
Wenzhe Ho
20. NeuroHIV and the Glymphatic System
Dianne Langford
21. The p75 neurotrophin receptor: emerging role in the pathogenesis of mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Andrew Speidell and Italo Mocchetti
22. The Role of HIV-Associated Neuroendocrine Dysfunction in HAND
Jason J. Paris
23. Impact of SARS-CoV-2/COVID-19 on HIV-1-associated neurocognitive disorders
Huangui Xiong
24. Molecular mechanisms of dopaminergic transmission in NeuroHIV
Jun Zhu
25. The effect of substance misuse on HIV persistence in the CNS: epidemiological, immunological, and molecular considerations
Teresa LuPone, Rachel VanDuyne, Erick O'Brien, Stephanie Matt, William Dampier, Michael Nonnemacher, Brian Wigdahl, Peter Gaskill and Zachary Klase
26. Extracellular vesicles in alcohol- and tobacco-induced neuroAIDS
Santosh Kumar, Asit Kumar, Sandip Godse, Lina Zhou, Golnoush Mirzahosseini and Krina Patel
27. NeuroHIV in the context of opioid use disorder: A complex and evolving relationship
MaryPeace McRae and Melanie Nicol
28. Impairment of cholesterol homeostasis induced by Nef-containing extracellular vesicles as a factor in HAND pathogenesis
Michael I. Bukrinsky
29. Long noncoding RNAs in immune response, viral infection, and opioid use
GUOKU HU
30. Using cross-species behavioral tools to determine mechanisms contributing to HIV associated neurological disorders and comorbid substance use
Jared W. Young
31. Therapeutic potential of Curcumin in treating HIV-1 associated neurocognitive disorders
Yanyan Xing and Huangui Xiong
32. Targeting the Endocannabinoid System in HAND
Sylvia Fitting
33. Predicting the effectiveness of combination treatment of Dolutegravir and Fluoxetine for Depressive disorders in HIV
Liana Bruggemann, Sana Qayum, Qing Ma, Andrew Ocque, Ravikumar Aalinkeel, Ram Samudrala,
Gene D. Morse, Stanley A Schwartz and Supriya Dinkar Mahajan
34. ANTIRETROVIRAL THERAPY AND ITS CEREBRAL VASCULAR TOXICITY
Harrison Kyle Rudd and Michal Toborek
35. Strategies for HIV-1 Elimination
Chen Zhang, Emiko Waight and Prasanta Kumar Dash
Howard E. Gendelman
1. An overview of the mechanisms of HIV-1 infection, latency, pathogenesis, and eradication strategies from the CNS
Mudit Tyagi
2. Central Nervous System Complications of Human Immunodeficiency Virus Infection
Howard E. Gendelman
3. Health LIteracy in HIV-associated Neurocognitive Disorders
Ilex Beltran-Najera, Steven Paul Woods, Darrian Evans, Andrea Mustafa, Anastasia Matchanova and Jennifer Thompson
4. Neuroimaging insights into the CNS effects of HIV infection
Christine Fennema-Notestine and Amanda Bischoff-Grethe
5. Early and upstream subcellular organellar events associated with HAND
Jonathan D. Geiger, Peter W. Halcrow, Nimal Kumar and Darius Quansah
6. White matter loss and oligodendrocyte dysfunction in HAND
Judith B. Grinspan and Kelly L. Jordan-Sciutto
7. Pathogenesis of HIV-associated pain
Xin Liu and Shao-Jun Tang
8. Neuropathogenesis of HIV-associated neuropathic pain
Shuanglin Hao
9. Neuropathic Pain in HIV and the role of the Autophagy pathway
Myosotys Rodriguez, Marissa Pokharel, Florida Owens, Jay McLaughlin and Nazira El-Hage
10. Host peripheral immune dynamics increase HIV-associated neurocognitive disorders incidence and progression
Siddappa N. Byrareddy
11. The role of immunometabolism in HIV associated depression and cognitive impairment
Ronald J. Ellis and Mohammadsobhan Andalibi
12. Role of extracellular viral regulatory proteins in neuropathogenesis
Michael Nonnemacher, Rachel Berman, Jill Lawrence, Collins MacKenzie, Ted Gurrola, William Dampier and Brian Wigdahl
13. Role of inflammasomes in HIV-1 and drug abuse-mediated neuroinflammation
Shilpa Buch and Palsamy Periyasamy
14. The Contribution of Myeloid Cells to HIV Neuropathogenesis
Veronica Veksler, Tina M. Calderon and Joan W. Berman
15. Immunophilin ligands modulate phagocytosis and viral replication in HIV-infected macrophages
Anish Vinay Sathe, Ana Sanchez, Benchawanna Soontornniyomkij, Mary Swinton, Shibangi Pal and Cristian Achim
16. Immunometabolic mechanisms of HIV-associated neurocognitive disorders and traumatic brain injury: Commonalities and contrasts between chronic and acute neurodegenerative pathologies
Jacqueline Kulbe and Jerel Adam Fields
17. Endolysosome dysfunction in HAND
Wendie Hasler, Neda Rezagholizadeh and Xuesong Chen
18. Evolving biomarkers for HIV-associated neurocognitive disorders (HAND)
LYNN PULLIAM
19. Intracellular immunity against HIV infection
Wenzhe Ho
20. NeuroHIV and the Glymphatic System
Dianne Langford
21. The p75 neurotrophin receptor: emerging role in the pathogenesis of mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Andrew Speidell and Italo Mocchetti
22. The Role of HIV-Associated Neuroendocrine Dysfunction in HAND
Jason J. Paris
23. Impact of SARS-CoV-2/COVID-19 on HIV-1-associated neurocognitive disorders
Huangui Xiong
24. Molecular mechanisms of dopaminergic transmission in NeuroHIV
Jun Zhu
25. The effect of substance misuse on HIV persistence in the CNS: epidemiological, immunological, and molecular considerations
Teresa LuPone, Rachel VanDuyne, Erick O'Brien, Stephanie Matt, William Dampier, Michael Nonnemacher, Brian Wigdahl, Peter Gaskill and Zachary Klase
26. Extracellular vesicles in alcohol- and tobacco-induced neuroAIDS
Santosh Kumar, Asit Kumar, Sandip Godse, Lina Zhou, Golnoush Mirzahosseini and Krina Patel
27. NeuroHIV in the context of opioid use disorder: A complex and evolving relationship
MaryPeace McRae and Melanie Nicol
28. Impairment of cholesterol homeostasis induced by Nef-containing extracellular vesicles as a factor in HAND pathogenesis
Michael I. Bukrinsky
29. Long noncoding RNAs in immune response, viral infection, and opioid use
GUOKU HU
30. Using cross-species behavioral tools to determine mechanisms contributing to HIV associated neurological disorders and comorbid substance use
Jared W. Young
31. Therapeutic potential of Curcumin in treating HIV-1 associated neurocognitive disorders
Yanyan Xing and Huangui Xiong
32. Targeting the Endocannabinoid System in HAND
Sylvia Fitting
33. Predicting the effectiveness of combination treatment of Dolutegravir and Fluoxetine for Depressive disorders in HIV
Liana Bruggemann, Sana Qayum, Qing Ma, Andrew Ocque, Ravikumar Aalinkeel, Ram Samudrala,
Gene D. Morse, Stanley A Schwartz and Supriya Dinkar Mahajan
34. ANTIRETROVIRAL THERAPY AND ITS CEREBRAL VASCULAR TOXICITY
Harrison Kyle Rudd and Michal Toborek
35. Strategies for HIV-1 Elimination
Chen Zhang, Emiko Waight and Prasanta Kumar Dash
Review quotes
Review quotes
*4 stars* "...a comprehensive and insightful volume that delves into the complex and evolving challenges posed by HIV infection and its impact on neurocognitive functions....[P]rovides a thorough, up-to-date, and practical guide to understanding and managing HAND and provides valuable insights into a complex and often under-recognized aspect of HIV care. [An] invaluable resource for students, and anyone involved in the care of individuals with HIV or interested in the neurological aspects of infectious diseases....[P]rovides a better understanding of the neurological complications of HIV/AIDS, [and] a comprehensive yet concise review of a dynamic field with an interdisciplinary approach....I highly recommend it to clinicians and researchers who are interested in the interplay between the central nervous system and HIV infection." —©Doody’s Review Service, 2024, Sarah M Stuccio, MD (Thomas Jefferson University)
Product details
Product details
- Edition: 1
- Latest edition
- Published: February 27, 2024
- Language: English
About the editors
About the editors
GH
Guoku Hu
Dr. Hu is an Associate Professor in the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center. His work is focused on mRNA biology, with the ultimate goal of elucidating their functional aspects in drug addiction, and also to identify novel therapeutic strategies that could enhance neuronal function and survival in patients afflicted with these disorders.
Affiliations and expertise
Associate Professor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USAHX
Huangui Xiong
Dr. Xiong is a Professor in the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center and leader of the University of Nebraska Medical Center Neurophysiology Laboratory in the Center for Neurovirology and Neurodegenerative Disorders. He is a neuroelectrophysiologist working in the field of NeuroAIDS (the neurological complications of AIDS), which include neurocognitive impairment and HIV-associated dementia (HAD). Current research in his laboratory studies molecular and cellular mechanisms underlying HIV-1-associated cellular and synaptic dysfunction and injury, with the ultimate goal of identifying potential target(s) for the development of therapeutic strategies. Dr. Xiong is the author of Current Laboratory Methods in Neuroscience Research (Springer) and has additionally authored many book chapters.
Affiliations and expertise
Professor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USASB
Shilpa Buch
Dr. Buch is a Professor and Executive Vice-Chair of the Department of Pharmacology and Experimental Neuroscience at University of Nebraska Medical Center. Her research focuses on understanding the neuropathogenesis of HIV/SIV infection using cell culture, rodents and macaques as model systems. She is the director of the Nebraska Center for Substance Abuse Research, the mission of which is to promote and enhance drug abuse research and mentor trainees in this area. Dr. Buch is a Member of the European Academy of Sciences, and a Member of the Royal Academy of Belgium.
Affiliations and expertise
Professor and Senior Executive Vice-Chair, Department of Pharmacology and Experimental Neuroscience, Director – Nebraska Center for Substance Abuse Research, University of Nebraska Medical Center, Omaha, Nebraska, USAView book on ScienceDirect
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